On February 26, 2018 TESARO, Inc. (NASDAQ:TSRO), an oncology-focused biopharmaceutical company, reported that it has entered into a clinical collaboration with Genentech, a member of the Roche Group, to evaluate the combination of the PD-L1 antibody atezolizumab (TECENTRIQ) and TESARO’s PARP-inhibitor ZEJULA (niraparib) in patients with metastatic bladder cancer (Press release, TESARO, FEB 26, 2018, View Source [SID1234524184]).

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"This collaboration enables us to expand the clinical assessment of niraparib and PD(L)-1 combinations beyond ovarian, breast and lung cancer," said Mary Lynne Hedley, Ph.D., President and COO of TESARO. "The combination of these two therapies could provide a potential option for patients with advanced bladder cancer, for whom mechanisms of immune escape, despite significant recent advances with anti-PD(L)-1 agents, remain a clinically relevant unmet need."

The collaboration includes testing the experimental combination in MORPHEUS, Roche’s novel cancer immunotherapy development platform. MORPHEUS is a Phase 1b/2 adaptive platform to develop combinations of cancer immunotherapies more rapidly and efficiently. The planned trial will be conducted by Genentech and is expected to begin mid-2018.

TECENTRIQ (atezolizumab) is a registered trademark of Genentech, a member of the Roche Group.