On March 1, 2018 Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL), reported that fostamatinib data from its FIT Phase 3 extension study (FIT3) in patients with chronic immune thrombocytopenia (ITP) and preliminary data from its SOAR Phase 2 clinical study in patients with warm antibody autoimmune hemolytic anemia (AIHA) will be presented at the 4th Biennial Summit of the Thrombosis & Hemostasis Societies of North America on March 8 – 10, 2018 in San Diego, CA (Press release, Rigel, MAR 1, 2018, View Source;p=RssLanding&cat=news&id=2335578 [SID1234524328]).
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Fostamatinib disodium is an oral investigational drug candidate designed to inhibit spleen tyrosine kinase (SYK), a key signaling component of the body’s immune process that leads to platelet destruction in ITP and red blood cell destruction in AIHA. SYK inhibition by fostamatinib can affect antibody-mediated platelet destruction, an underlying cause of ITP. Fostamatinib may also impair antibody-mediated red blood cell destruction in AIHA, a rare disease for which there are no approved therapies.
Fostamatinib Oral Presentation
Date and Time: Saturday, March 10, 10:15am PT
Location: Marriott Grand Ballroom 10, Marriott Marquis, San Diego
Title: Platelet Responses in Placebo Patients with Long-Duration Chronic Immune Thrombocytopenia Initiating Fostamatinib in the 049 Open-Label Extension Study
Fostamatinib Poster Presentation
Date and Time: Thursday, March 8, 3:30-4:15pm PT
Location: Pacific Ballroom, Marriott Marquis, San Diego
Title: Fostamatinib, a Spleen Tyrosine Kinase Inhibitor, is Active in the Treatment of Warm Antibody Autoimmune Hemolytic Anemia: Results of the SOAR Phase 2, Multicenter, Open-Label Study
ePoster #35 (Electronic poster)
About ITP
In patients with ITP, the immune system attacks and destroys the body’s own blood platelets, which play an active role in blood clotting and healing. Common symptoms of ITP are excessive bruising and bleeding. People suffering with chronic ITP may live with an increased risk of severe bleeding events that can result in serious medical complications or even death. Current therapies for ITP include steroids, blood platelet production boosters (TPOs) and splenectomy. However, not all patients are adequately treated with existing therapies. As a result, there remains a significant medical need for additional treatment options for patients with ITP.
About AIHA
Autoimmune hemolytic anemia (AIHA) is a rare, serious blood disorder in which the immune system produces antibodies that result in the destruction of the body’s own red blood cells. AIHA affects approximately 40,000 adult patients in the US and can be a severe, debilitating disease. To date, there are no FDA approved disease-targeted therapies for AIHA, despite the tremendous medical need that exists for these patients.