On February 10, 2025 Rondo Therapeutics, a privately held biopharmaceutical immuno-oncology company pioneering the development of next-generation T cell-engaging bispecific antibodies for the treatment of solid tumors, reported that data from preclinical studies of RNDO-564, a novel CD28 x Nectin-4 costimulatory bispecific antibody for advanced bladder cancer, is being presented in a poster session at the 2025 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Genitourinary (GU) Cancers Symposium, taking place February 13-15, 2025, in San Francisco, CA (Press release, Rondo Therapeutics, FEB 10, 2025, View Source [SID1234650150]).
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"CD28 co-stimulatory bispecific antibodies are designed to boost T cell-mediated tumor killing and overcome T cell exhaustion in the solid tumor microenvironment. In preclinical studies, RNDO-564 demonstrated robust anti-tumor activity in vivo and in vitro, including in an antibody drug conjugate (ADC)-resistant bladder cancer model, suggesting the ability of RNDO-564 to overcome T cell exhaustion and address limitations of ADCs, including toxicity, resistance, and sequential ADC re-challenge," said Thomas Manley, CMO of Rondo Therapeutics. "Based on these promising preclinical findings, we are advancing RNDO-564 through IND-enabling studies, with the goal of entering the clinic in advanced bladder cancer by year-end."
Key Findings
RNDO-564 is designed to elicit robust Nectin-4 and signal-1 dependent T-cell mediated killing of Nectin-4-expressing tumor cells
RNDO-564 restored tumor cell killing function of serially stimulated T cells in vitro
RNDO-564 inhibited tumors in vivo as monotherapy and in combination with checkpoint therapy in vivo
Preliminary toxicology studies support clinical evaluation of RNDO-564
RNDO-564 maintained cytotoxicity against antibody drug conjugate-resistant bladder cancer cells
Poster Session Details
Title:
A novel CD28 x Nectin-4 costimulatory bispecific antibody for advanced bladder cancer
Poster No.:
810
Session:
Poster Session B: Urothelial Carcinoma
Date/Time:
Friday, February 14, 2025 = 11:30am-12:45pm PST
Rondo Therapeutics’ proprietary platform features CD28-targeting binders with a wide range of co-stimulatory potencies designed to boost T cell-mediated tumor killing and overcome T cell exhaustion in the solid tumor microenvironment. Rondo’s platform delivers bispecific antibody therapeutics tailored to specific tumor targets, indications, and treatment regimens, offering a transformative alternative to traditional "one size fits all" strategies, unlocking the potential for durable responses in patients with solid tumors.