7th Annual European Antibody Congress 2011

Using both Fc mutants and wild type Chinese hamster ovary (CHO) cells as a model, iDD biotech generated anti CD19 antibodies displaying different levels of fucosylation as demonstrated by MALDI-TOF mass spectrometry based glycoprofiling (Poster, 7th Annual European Antibody Congress 2011, November 29–December 1, 2011, Geneva, Switzerland, iDD biotech, NOV 29, 2011, View Source [SID:1234502456]). The downmodulation of the fucose level also led to the construction of antiCD19 MAbs with a strongly enhanced ADCC effector function.

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