On February 26, 2024 GC Cell, a fully integrated cell therapy pioneer reported a strategic partnership with BioCentriq, a cell therapy contract development and manufacturing organization (CDMO) and US affiliate of GC Cell (Press release, GC Cell, FEB 26, 2024, View Source [SID1234640473]). This important partnership lays the foundation to bring GC Cells’ proven cell-based immunotherapy, Immuncell-LC to the North American market. The execution of a Process Transfer Agreement with BioCentriq effectively lays the foundation for the U.S. launch of Immuncell-LC through utilization of BioCentriq’s cell therapy process development, analytical method development and manufacturing expertise.

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"The Process Transfer Agreement between GC Cell and BioCentriq initiates the groundwork for introducing Immuncell-LC to the U.S. market" said James Park, CEO of GC Cell. Our partnership with BioCentriq underscores our commitment to bringing innovative cancer therapies to patients in need across North America, marking a significant milestone in GC Cell’s global expansion strategy."

"We are thrilled to partner with GC Cell to bring Immuncell-LC, a proven autologous cell therapy to the U.S. Market. Our partnership further enables our mission of Delivering Hope to cancer patients with significant unmet medical needs" said Jennifer Manning, Chief Commercial Officer, BioCentriq.

Immuncell-LC is the only commercially available adoptive cell therapy treatment of early-stage HCC. It is primarily composed of autologous, cultured blood-derived T lymphocytes with proven efficacy through a large-scale Phase 3 clinical trial which reduced the risk of recurrence by 37% and decreased the mortality rate by 79% compared to the control group. To date, Immuncell-LC has been administered to over 10,000 patients in South Korea without serious adverse events.

On February 26, 2024 J INTS BIO reported that the Phase 1/2 clinical study of its Novel Oral 4th Generation EGFR TKI "JIN-A02" for the treatment of NSCLC has been accepted for poster presentation at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) meeting to be held in San Diego USA from 5 to 10 April (Press release, J INTS BIO, FEB 26, 2024, View Source [SID1234640472]).

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The American Association for Cancer Research (AACR) (Free AACR Whitepaper) is an authoritative cancer society and is considered one of the world’s top three societies in the field of cancer, along with the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) and the European Society of Medical Oncology (ESMO) (Free ESMO Whitepaper). J INTS BIO will present a poster during the "Phase I Clinical Trials in Progress" session, which will be held on April 8 from 1:30 to 5:00 p.m.

The topic of the presentation is "Phase 1/2 clinical trial of JIN-A02, a 4th generation EGFR-TKI for 3rd generation EGFR-TKI resistant patients in EGFR mutated advanced/metastatic non-small cell lung cancer".

‘JIN-A02’, a 4th generation EGFR-TKI, selectively binds to C797S, a mutation that leads to resistance to the use of 3rd generation EGFR-TKIs (such as Osimertinib, Lazertinib), in the treatment of EGFR+ NSCLC. ‘JIN-A02’ is highly selective for and strongly inhibits NSCLC with C797S double or triple mutations and is expected to show efficacy against intracranial tumors due to its high blood-brain barrier permeability.

In August last year, J INTS BIO registered the first patient for the global Phase 1/2 clinical trial of ‘JIN-A02’ at Severance Hospital in Korea. This clinical study is currently recruiting patients with EGFR mutation-positive and advanced NSCLC at in Korea, including Asan Medical Center and the National Cancer Center, and the University of California (U.C. Irvine).

The dose escalation part of the study is now at its 4th dose level, and despite the preceding low dose levels, early efficacy responses were observed in targeted lesions, especially in patients with the C797S mutation. J INTS BIO plans to expand the number of clinical trial sites globally and in Korea, this will include Seoul National University Hospital, Samsung Seoul Hospital, and Seoul St. Mary’s Hospital.

A J INTS BIO official said, "The global clinical trial for ‘JIN-A02’ is progressing well and is receiving interest in the global market."

Details of the AACR (Free AACR Whitepaper) presentation will be released on April 8th.

On February 26, 2024 Compugen Ltd. (NASDAQ: CGEN) (TASE: CGEN) a clinical-stage cancer immunotherapy company and a pioneer in computational target discovery, reported that management will participate in a fireside chat at the Leerink Partners Global Biopharma Conference, Miami Beach, Florida, on Monday, March 11, 2024 at 11:20 AM ET (Press release, Compugen, FEB 26, 2024, View Source [SID1234640471]).

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A live webcast of the presentation will be available on the Investor Relations section of Compugen’s website at www.cgen.com. A replay will be available following the live event.

On February 26, 2024 Fusion Pharmaceuticals Inc. (Nasdaq: FUSN), a clinical-stage oncology company focused on developing next-generation radiopharmaceuticals as precision medicines, reported that the Company will participate in two upcoming investor conferences (Press release, Fusion Pharmaceuticals, FEB 26, 2024, View Source [SID1234640470]).

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TD Cowen 44th Annual Health Care Conference – The Company will participate in the "Prostate Cancer Corporate Panel Discussion" taking place on March 4, 2024, at 10:30 a.m. ET in Boston, MA. Participating on behalf of Fusion will be President and Chief Business Officer Mohit Rawat.

Leerink Partners 2024 Global Biopharma Conference – The Company fireside chat presentation will take place on Tuesday, March 12, 2024, at 4:20 p.m. ET in Miami, FL. Participating on behalf of Fusion will be President and Chief Business Officer Mohit Rawat.

Webcasts of each event will be available on the "Events and Presentations" page in the "Investors & Media" section of the Company’s website at View Source A replay of the webcast will be archived on the Company’s website for 90 days following their respective presentation dates.

On February 26, 2024 Coeptis Therapeutics Holdings, Inc. (NASDAQ: COEP) (the "Company" or "Coeptis"), a biopharmaceutical company developing innovative cell therapy platforms for cancer, autoimmune, and infectious diseases, reported that it has expanded its exclusive license agreement with the University of Pittsburgh to include autoimmune indications as part of its ongoing development of SNAP-CAR T and SNAP-CAR NK (Press release, Coeptis Therapeutics, FEB 26, 2024, View Source [SID1234640469]). This amended agreement builds upon the original exclusive license agreement with the University of Pittsburgh for SNAP-CAR T Cells, a "universal" CAR T technology platform designed to target multiple antigens simultaneously and potentially address a range of hematologic and solid tumors, and a recent amendment to the agreement for SNAP-CAR NK, an allogeneic natural killer (NK) cell therapy platform.

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Autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis, are known to result from autoreactive B cells. Recent research, including a paper just published in The New England Journal of Medicine, suggests that CD19-targeting chimeric antigen receptor (CAR) T cells, which have proven to be highly efficient in B cell malignancies, can also target autoreactive B cells that trigger autoimmune diseases.

Research published in the peer-reviewed journal Nature Communications demonstrated the ability of SNAP-CAR to provide a powerful adaptor strategy for fully programmable targeting of engineered cells to multiple antigens, including CD19. Based on these findings, Coeptis Therapeutics plans to expand the development of the SNAP-CAR platform to target the multibillion-dollar autoimmune disease market in addition to hematologic and solid tumors.

"We remain committed to developing these remarkable technologies as treatments for various indications across oncology where there is immense unmet need, however we also recognize the enormous potential for these platform technologies to address and possibly revolutionize the treatment landscape of autoimmune diseases," said Dave Mehalick, President and CEO of Coeptis Therapeutics. "Our SNAP-CAR technologies have the potential to position us at the forefront of next-generation autoimmune directed therapies targeting multiple antigens through combinatorial use of different adaptors."

"We are again excited to expand our license with Coeptis," said Jason Lohmueller, Ph.D., Assistant Professor of Surgery and Immunology in the Division of Surgical Oncology Research, University of Pittsburgh. "Leveraging the universal SNAP-CAR technology, may bring multiple exciting and revolutionary treatments modalities to the clinic for diverse indications in oncology and autoimmune disease, benefiting patients and the entire healthcare industry."

According American Autoimmune Related Disease Association, there are more than 100 autoimmune diseases impacting 1 in every 5 Americans, 75% of whom are women. These diseases are among the top 10 causes of death in America, causing great pain and suffering, with significant socioeconomic impact as well. Globally, the treatment market is forecasted to grow from $7.68 billion in 2024 to $12.64 in 2028, to according to The Business Research Company.