Soligenix to Present at The Microcap Conference

On January 25, 2024 Soligenix, Inc. (Nasdaq: SNGX) (Soligenix or the Company), a late-stage biopharmaceutical company focused on developing and commercializing products to treat rare diseases where there is an unmet medical need, reported that the Company will deliver a corporate presentation at The Microcap Conference (Press release, Soligenix, JAN 25, 2024, View Source [SID1234639484]). The conference will be held January 30 and 31, and February 1, 2024 at Caesars Atlantic City Hotel & Casino in Atlantic City, N.J. For more information about The Microcap Conference, please refer to the conference website at View Source

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Registered conference attendees may schedule one-on-one meetings with Soligenix management via the conference scheduling platform. If you are unable to attend the conferences and would like to schedule a meeting with management, please contact [email protected].

SELLAS Life Sciences to Present SLS009 Phase 1 Data from Acute Myeloid Leukemia Patients at the 2024 European School of Haematology (ESH) Conference

On January 25, 2024 SELLAS Life Sciences Group, Inc. (NASDAQ: SLS) ("SELLAS" or the "Company"), a late-stage clinical biopharmaceutical company focused on the development of novel therapies for a broad range of cancer indications, reported that data from the acute myeloid leukemia cohort of patients in the Phase 1 dose-escalation study of SLS009 (formerly GFH009) will be presented in an oral presentation at the 2024 European School of Haematology Acute Leukaemias (ESH) Conference: 4th How to Diagnose and Treat Acute Leukaemias, taking place March 1-3, 2024, in Stockholm, Sweden (Press release, Sellas Life Sciences, JAN 25, 2024, View Source [SID1234639483]).

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The presentation details are below:

Title: Phase 1 Dose-Escalation Study of GFH009 in Acute Myeloid Leukemia
Session Date and Time: Sunday, March 3, 2024, at 12 pm CET
Session Title: Leukemia Treatment Challenges
Presenter: Dr. Tapan Kadia, Professor in the Department of Leukemia at The University of Texas MD Anderson Cancer Center in Houston, Texas
Abstract Number: 6192705

Repare Therapeutics Announces Achievement of $40 Million Roche Clinical Milestone Payment

On January 25, 2024 Repare Therapeutics Inc. ("Repare" or the "Company") (Nasdaq: RPTX), a leading clinical-stage precision oncology company, reported that, under its worldwide license and collaboration agreement with Roche for the development and commercialization of camonsertib, it has earned a $40 million milestone payment from Roche upon dosing of the first patient with camonsertib (RP-3500 or RG6526) in Roche’s TAPISTRY trial (NCT04589845) (Press release, Repare Therapeutics, JAN 25, 2024, View Source [SID1234639482]). TAPISTRY is a Phase 2, global, multicenter, open-label, multi-cohort clinical trial designed to evaluate the safety and efficacy of targeted therapies or immunotherapy in participants with unresectable, locally advanced or metastatic solid tumors determined to harbor specific oncogenic genomic alterations.

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In October, Roche also enrolled the first patient in a camonsertib-based arm in its Phase 1b/2 clinical trial of multiple immunotherapy-based treatment combinations in participants with metastatic non-small cell lung cancer (Morpheus Lung; NCT03337698). The TAPISTRY and MORPHEUS trials are actively enrolling patients. In collaboration with Roche, Repare is continuing to conduct tumor specific expansions in the ATTACC trial to support future clinical development for camonsertib + PARP inhibitor combinations.

"This milestone is a key achievement for us, demonstrating Roche’s commitment to the global clinical development of camonsertib and highlighting their exploration of development opportunities for camonsertib across multiple tumor types and genetic alterations to maximize patient impact," said Lloyd M. Segal, President and Chief Executive Officer of Repare.

Under the terms of its collaboration with Roche, Repare received a $125 million upfront payment in July 2022, as well as $13.6 million in additional payments, and is eligible to receive up to $1.2 billion in potential clinical, regulatory, commercial and sales milestone payments, and royalties on global net sales ranging from high-single-digits to high-teens. The collaboration also provides Repare with the ability to opt-in to a 50/50 U.S. co-development and profit share arrangement, including participation in U.S. co-promotion if U.S. regulatory approval is received. If Repare chooses to exercise its

co-development and profit share option, it will continue to be eligible to receive certain clinical, regulatory, commercial and sales milestone payments, in addition to full ex-U.S. royalties.

About Repare Therapeutics’ SNIPRx Platform

Repare’s SNIPRx platform is a genome-wide CRISPR-based screening approach that utilizes proprietary isogenic cell lines to identify novel and known synthetic lethal gene pairs and the corresponding patients who are most likely to benefit from the Company’s therapies based on the genetic profile of their tumors. Repare’s platform enables the development of precision therapeutics in patients whose tumors contain one or more genomic alterations identified by SNIPRx screening, in order to selectively target those tumors in patients most likely to achieve clinical benefit from resulting product candidates.

RedHill Biopharma Announces $8 Million Registered Direct Offering

On January 25, 2024 RedHill Biopharma Ltd. (Nasdaq: RDHL) ("RedHill" or the "Company"), a specialty biopharmaceutical company, reported that it has entered into definitive agreements with institutional investors for the purchase and sale of 10,000,000 of the Company’s American Depositary Shares ("ADSs"), each ADS representing four hundred (400) ordinary shares, at a purchase price of $0.80 per ADS, in a registered direct offering (Press release, RedHill Biopharma, JAN 25, 2024, View Source [SID1234639481]). In addition, in a concurrent private placement, the Company will issue unregistered warrants to purchase up to 10,000,000 ADSs. The warrants will have an exercise price of $1.00 per ADS, will be immediately exercisable upon issuance and have a term of five years following the issuance date. The closing of the offering is expected to occur on or about January 29, 2024, subject to the satisfaction of customary closing conditions.

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H.C. Wainwright & Co. is acting as the exclusive placement agent for the offering.

The gross proceeds to the Company from the offering are expected to be $8 million, before deducting the placement agent’s fees and other offering expenses payable by the Company. The Company intends to use the net proceeds from the offering for general working capital, acquisitions, research and development, and general corporate purposes.

The ADSs described above (but not the warrants issued in the private placement or the ADSs underlying the warrants) are being offered by the Company pursuant to a "shelf" registration statement on Form F-3 (File No. 333-258259) previously filed with the Securities and Exchange Commission (the "SEC") on July 29, 2021, and declared effective by the SEC on August 9, 2021. The offering of the ADSs is made only by means of a prospectus, including a prospectus supplement, forming a part of the effective registration statement. A final prospectus supplement and accompanying prospectus relating to the offering of ADSs will be filed with the SEC. Electronic copies of the final prospectus supplement and accompanying prospectus may be obtained, when available, on the SEC’s website at View Source or by contacting H.C. Wainwright & Co., LLC at 430 Park Avenue, 3rd Floor, New York, NY 10022, by phone at (212) 865-5711 or e-mail at [email protected].

The warrants described above are being issued in a concurrent private placement under Section 4(a)(2) of the Securities Act of 1933, as amended (the "Securities Act"), and Regulation D promulgated thereunder and, along with the ADSs underlying the warrants, have not been registered under the Securities Act, or applicable state securities laws. Accordingly, the warrants and underlying ADSs may not be offered or sold in the United States except pursuant to an effective registration statement or an applicable exemption from the registration requirements of the Securities Act and such applicable state securities laws.

This press release shall not constitute an offer to sell or a solicitation of an offer to buy any of the securities described herein, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

QIAGEN announces partnership with Penn State University to advance microbiome sciences

On January 25, 2024 QIAGEN (NYSE: QGEN; Frankfurt Prime Standard: QIA) reported a first-in-kind collaboration with Penn State University in the United States to create a shared research and education facility for the fast-developing microbiome sciences (Press release, Qiagen, JAN 25, 2024, View Source [SID1234639480]).

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The university-industry partnership will serve as a beacon for this field by investigating research opportunities that address challenges and research gaps facing the microbiome, which involves the research into a community of microorganisms that can be found living together in any given environment, including the human body.

In doing so, this new partnership will provide QIAGEN with a site to support the development of new products as a testing center. It is also designed to provide vital industry research and training opportunities for next-generation scientists. This includes an internship program for graduate students from Penn State at QIAGEN laboratories at the European operational headquarters in Hilden, Germany, and helps them prepare for careers in the biotechnology industry.

"This new partnership with Penn State, one of the leading academic research institutions in the field of microbiome research, is anchored by a shared vision for an interconnection between the health of humans, animals and ecosystems. It will help shape research, education and outreach in the young field of the microbiome sciences, and hopefully accelerate the careers of a new generation of scientists interested in this field," said Nitin Sood, Senior Vice President and Head of the Life Sciences Business Area at QIAGEN. "Additionally, it will foster relationships with the microbiome research community and enable us to better develop new products for microbiome research based on direct customer feedback."

Seth Bordenstein, Director of the One Health Microbiome Center, Professor of Biology and Entomology, and Huck Endowed Chair in the Microbiome Sciences, at Penn State said: "The ‘One Health’ vision shared by QIAGEN and Penn State University is critical for microbiome research. We are pleased to partner with the leading provider of microbiome solutions to equip researchers with the tools to explore how microorganisms flow through humans, animals, plants and the environment, impacting the health of all these ecosystems. With this multi-year partnership, we will bridge the gap between industry and academia and shape the future of microbiome research."

Among the various projects in this partnership, the team will support the worldwide science education program "Discover the Microbes Within! The Wolbachia Project". This program enables students at the middle and high school levels, as well as those in college, to learn about arthropods (animals without backbones that have an outer skeleton made of chitin, segmented bodies and legs with joints, including insects, spiders, mites and crustaceans) and collect scientific data about the bacterial endosymbiont (an organism living inside another one for the benefit of both) Wolbachia pipientis.

This bacterium is estimated to be found in approximately 50% of the world’s arthropods and has been shown, for example, to block the reproduction of potentially fatal RNA viruses such as Dengue, West Nile and Zika virus[1]. Additionally, it is used to reduce the transmission of these and other viruses spread by the bite of infected arthropods (arboviruses)[2]. Due to these real-world impacts, Wolbachia is often used as a model organism to investigate animal-microbe interactions, genetics, evolution, ecology and human health.

Microbiome research aims to explore the relationships between microorganisms such as bacteria, fungi and viruses, and their hosts. It can help to better understand the microbiome’s impact on health, diseases and ecological processes in order to develop novel diagnostic solutions and therapeutic strategies.

The flagship project at the One Health Microbiome Center (OHMC) at Penn State’s Huck Institutes of the Life Sciences will see QIAGEN provide instruments and kits for preparing and processing microbial samples.

Penn State is among the top 30 public research universities in the U.S., with more than $1.2 billion in annual research expenditures. With over 500 members, including 125 faculty from various Penn State campuses and more than 42 departments, OHMC is one of the largest organizations of its type in microbiome research.

QIAGEN’s comprehensive microbiome portfolio encompasses tools for every aspect of the scientific workflow, including reliable sample preparation kits optimized for investigating challenging samples from environmental and human microbiomes. To ensure reproducibility, QIAGEN offers sample preparation automation for standardization and reliability. The extensive range of microbiome solutions also includes downstream processing technologies such as NGS, digital PCR (dPCR), or quantitative PCR (qPCR), all complemented by robust bioinformatics tools for seamless digital analysis.

Learn more about QIAGEN’s solutions for microbiome research at View Source