On January 3, 2024 Cellectar Biosciences, Inc. (NASDAQ: CLRB), a late-stage clinical biopharmaceutical company focused on the discovery, development and commercialization of drugs for the treatment of cancer, reported that it will host a call detailing top-line data from its pivotal trial of iopofosine I 131 in Waldenstrom’s macroglobulinemia on Monday, January 8, 2024 at 8:00 am ET (Press release, Cellectar Biosciences, JAN 3, 2024, View Source [SID1234638905]). The company will also be presenting at the Biotech Showcase conference the following day. Details for each event are as follows:

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Top-line Conference call details:
Date: Monday, January 8, 2024
Time: 8:00 am ET / 5:00 am PT
Dial-in: 1-888-886-7786
Webcast Link: Click HERE

Biotech Showcase Presentation
Date: Tuesday, January 9, 2024
Time: 5:00 pm ET / 2:00 pm PT
Location: Hilton San Francisco Union Square
Webcast: Click HERE
A replay of both the conference call and Biotech Showcase presentation will be available on the investor’s portion of the company’s website.

On January 3, 2024 BridgeBio Pharma, Inc. (Nasdaq: BBIO) ("BridgeBio" or the "Company"), a commercial-stage biopharmaceutical company focused on genetic diseases and cancers, reported that the United States Food and Drug Administration (FDA) has cleared the investigational new drug (IND) application for BBO-8520, a first-in-class orally bioavailable and highly potent small molecule direct inhibitor of KRASG12C (ON) state (Press release, BridgeBio, JAN 3, 2024, View Source [SID1234638904]). BBO-8520 binds covalently to the Switch II pocket in both the GTP-bound (ON) and GDP-bound (OFF) state conformations of KRASG12C, leading to rapid and robust inhibition of KRASG12C activity.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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BBO-8520’s ability to inhibit the (ON) state should provide optimal target coverage and address KRASG12C amplification and receptor tyrosine kinase activation – the two key mechanisms of adaptive resistance to current (OFF) state inhibitors. BBO-8520 drives substantial tumor growth inhibition in multiple preclinical models, even after emergence of resistance to sotorasib, an FDA approved (OFF) state inhibitor of KRASG12C.

"Clinical results from the first generation of KRASG12C inhibitors suggest that compounds with better potency and the ability to target the ON state are likely to lead to better outcomes," said Frank McCormick, Ph.D., Chairman of Oncology at BridgeBio, David A. Wood Distinguished Professor of Tumor Biology and Cancer Research at UCSF and advisor to the National Cancer Institute’s RAS Initiative at Frederick National Laboratory for Cancer Research (FNL). "BBO-8520 is the most potent G12C inhibitor with an IND, and the only compound that directly binds and targets the ON state. We hope that this drug will bring significantly improved benefit for patients suffering from KRASG12C cancers."

BBO-8520’s discovery was the result of a collaboration between the RAS Initiative FNL, Lawrence Livermore National Laboratory and BridgeBio. It is specifically designed to provide patients afflicted with KRASG12C mutant cancers with a best-in-class, oral small molecule therapy that directly targets the tumor at its source – oncogenic KRASG12C GTP-bound (ON) signaling. Enrollment of patients with KRASG12C mutant non-small cell lung cancer into the ONKORAS-101 trial is expected to begin in H1 of this year.

On January 3, 2024 BridgeBio Pharma, Inc. (Nasdaq: BBIO) ("BridgeBio" or the "Company"), a commercial-stage biopharmaceutical company focused on genetic diseases and cancers, reported that members of its management team will present at the 42nd Annual J.P. Morgan Healthcare Conference in San Francisco, CA on Monday, January 8 at 8:15 am PT (Press release, BridgeBio, JAN 3, 2024, View Source [SID1234638903]).

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Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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To access the live webcast of BridgeBio’s presentation, please visit the "Events & Presentations" page within the Investors section of the BridgeBio website at View Source A replay of the webcast will be available on the BridgeBio website for 30 days following the event.

On January 3, 2024 BioMarin Pharmaceutical Inc. (NASDAQ: BMRN) reported that Alexander Hardy, President and Chief Executive Officer of BioMarin, will present at the 42nd Annual J.P. Morgan Conference on Monday January 8, 2024, at 10:30 am PT / 1:30 pm ET, in San Francisco, California (Press release, BioMarin, JAN 3, 2024, View Source,-January-8,-at-10-30-am-PT-1-30-pm-ET,-in-San-Francisco,-CA [SID1234638902]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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An audio webcast of the presentations will be available live. You can access the webcasts at: View Source An archived version of the remarks will also be available through the Company’s website for a limited time following the conference.

On January 3, 2024 BioCryst Pharmaceuticals, Inc. (Nasdaq: BCRX) reported that the company will present at the 42nd Annual J.P. Morgan Healthcare Conference in San Francisco on Tuesday, January 9, 2024, at 6:00 p.m. ET (Press release, BioCryst Pharmaceuticals, JAN 3, 2024, View Source [SID1234638901]).

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Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Link to the live audio webcast and replay of the presentation may be accessed in the Investors & Media section of BioCryst’s website at http://www.biocryst.com.