On January 4, 2024 Evotec SE (Frankfurt Stock Exchange: EVT, MDAX/TecDAX, ISIN: DE0005664809; NASDAQ: EVO) and Owkin, a French-American techbio company reported an A.I.-powered integrated multi-target collaboration in oncology, immunology and inflammation ("I&I") (Press release, Evotec, JAN 4, 2024, View Source [SID1234638959]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The collaboration brings together highly complementary platforms and expertise to accurately select targets, discover and develop new therapeutics. Harmonising Owkin’s cutting-edge target discovery engine with Evotec’s end-to-end shared R&D platforms and disease biology expertise will accelerate Owkin’s novel programmes from the discovery phase to the clinic.

Owkin will identify indication-relevant targets and subgroups using A.I. applied to multimodal patient data. Evotec will leverage its shared R&D platform to accelerate and de-risk the validation of targets, identification of drug candidates and successful completion of pre-clinical development activities up to IND. An Owkin-Evotec joint Research Strategy Team formed of highly experienced drug hunters will drive the collaboration, designing fully tailored strategic programme plans from target selection to IND and ensuring delivery of the programmes. The partnership also enables Owkin to maximise capital efficiency while reducing risk. Evotec will receive R&D funding from Owkin and is eligible to earn performance milestone payments and royalties on product sales.

Dr Matthias Evers, Chief Business Officer of Evotec, commented: "Owkin and Evotec both feel there is something special brewing by convergence between A.I. and science in drug innovation – hence, we are thrilled to strike this partnership towards accelerating therapeutics in therapeutic areas of highest unmet needs – patients need us, together."

Dr Thomas Clozel, Co-founder and CEO of Owkin, remarked: "The combination of in silico hypothesis generation through A.I. and experimental lab validation is the core of our pipeline strategy. Evotec’s broad capabilities in drug discovery, which range all the way from target validation through to IND-enabling studies, coupled with their understanding of artificial intelligence and its implementation in their workflows make them an ideal partner for us."

On January 3, 2024 Pacylex Pharmaceuticals, a clinical-stage oncology innovator, reported that it is closing out a pivotal year with a string of accomplishments that validate its first-in-class oral cancer therapy, zelenirstat (Press release, Pacylex Pharmaceuticals, JAN 3, 2024, View Source [SID1234645055]). This momentum positions Pacylex perfectly for a Series B funding round or strategic partnership to fuel the next stage of its exciting journey.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Zelenirstat shines in Phase 1, exceeding expectations:

No Dose Limiting Toxicities (DLTs) up to the target drug exposure. In an all-comer Phase 1 study in refractory/relapsed lymphoma and solid tumor patients, there were no zelenirstat DLTs at doses ranging from 20 mg – to 210 mg.
Evidence of Efficacy. Even in heavily pre-treated patients with resistant cancers like ovarian, colorectal, bile duct, lung, and appendiceal, zelenirstat at the highest dose significantly improved both progression-free and overall survival.
Clinical Advancements. Phase 2a is underway in B-cell NHL (non-Hodgkin lymphoma) at the 210 mg dose. Similar studies are planned for solid tumors and acute myeloid leukemia, further amplifying the potential of zelenirstat across multiple cancer indications.
Beyond Phase 1: Additional achievements solidify zelenirstat’s potential:

Orphan Drug and Fast Track designations for AML. Regulatory recognition validates zelenirstat’s promise in this challenging cancer.
Potent Radiosensitization in Brain Cancer. zelenirstat outperformed standard-of-care treatments in preclinical models, opening doors for combination therapies.
Capital Efficiency and De-risking: Pacylex has progressed to Phase 2 on less than $20 million, demonstrating an ability to deliver results with lean operations.
Investing in the future of cancer treatment:

With zelenirstat demonstrating safety and efficacy in patients who have failed all available therapeutic options, Pacylex presents a compelling investment opportunity. We offer:

A first-in-class therapy with ibrutinib-like potential: zelenirstat targets a novel pathway, potentially surpassing existing treatments in efficacy and tolerability.
Multiple expansion avenues: Solid tumors, AML, and autoimmune disorders represent future growth opportunities.
Experienced and dedicated team: Our team of scientific and commercial leaders possesses a proven track record of success.
Join us in shaping the future of cancer care:

Pacylex is actively seeking Series B funding and strategic partnerships to fuel the next chapter of zelenirstat’s development. We invite investors to connect with us at Biotech Showcase during JPM Week to learn more about this groundbreaking therapy and participate in a truly disruptive force in the oncology landscape.

Meet us through the BIO Partnering. View Source

Meet us through the BTS Partnering. https://informaconnect.com/biotech-showcase/partnering/

Schedule a casual coffee or reception meeting! [email protected]

On January 3, 2024 Erasca, Inc., a clinical-stage precision oncology company singularly focused on discovering, developing, and commercializing therapies for patients with RAS/MAPK pathway-driven cancers, reported its participation in the 42nd annual J.P. Morgan Healthcare Conference being held at the Westin St. Francis Hotel in San Francisco, California. Jonathan E. Lim, M.D., chairman, CEO, and co-founder, will present an overview of the company on Tuesday, January 9, 2024 at 9:00 am Pacific Time in Elizabethan Room D. Dr. Lim and David M. Chacko, M.D., chief financial officer and chief business officer, will also participate in one-on-one investor meetings (Press release, Erasca, JAN 3, 2024, View Source [SID1234639349]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

A live audio webcast of the event will be available online at Erasca.com/events. An archived replay of the event will be available for 30 days following the webcast at Erasca.com/events.

On January 3, 2024 Dynavax Technologies Corporation (Nasdaq: DVAX), a commercial-stage biopharmaceutical company developing and commercializing innovative vaccines, reported that the Company will present at the 42nd Annual J.P. Morgan Healthcare Conference on Thursday, January 11 at 11:15 a.m. PT (Press release, Dynavax Technologies, JAN 3, 2024, View Source [SID1234638943]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The presentation will be webcast and may be accessed through the "Events & Presentations" page on the "Investors" section of the Company’s website at View Source

On January 3, 2024 Allogene Therapeutics, Inc. (Nasdaq: ALLO), a clinical-stage biotechnology company pioneering the development of allogeneic CAR T (AlloCAR T) products for cancer, reported that it will host a conference call to preview its 2024 Platform Vision focused on redefining the future of CAR T by leveraging the unique attributes of allogeneic CAR T products (Press release, Allogene, JAN 3, 2024, https://ir.allogene.com/news-releases/news-release-details/allogene-therapeutics-host-conference-call-previewing-its-2024 [SID1234638942]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The 2024 Platform Vision conference call will be hosted on Thursday, January 4, 2024, at 2:00 p.m. PT/5:00 p.m. ET.

David Chang, M.D., Ph.D., President, Chief Executive Officer and Co-Founder of Allogene, will also present the 2024 Platform Vision at the 42nd Annual J.P. Morgan Healthcare Conference on Wednesday, January 10, 2024, at 8:15 a.m. Pacific Time. This event will be held in San Francisco at the Westin St. Francis.

2024 Platform Vision Conference Call

Listen-Only Webcast
The listen-only webcast will be made available on the Company’s website at www.allogene.com under the Investors tab in the News and Events section.

Conference Call Registration
If you would like the option to ask a question on the conference call, please use this link to register. Upon registering for the conference call, you will receive a personal PIN to access the call.

JP Morgan Conference
A live audio webcast of the presentation will be made available on the Company’s website at www.allogene.com under the Investors tab in the News and Events section.

Following each live audio webcast, a replay will be available on the Company’s website for approximately 30 days.