On November 21, 2024 City of Hope, one of the largest and most advanced cancer research and treatment organizations in the United States and ranked among the nation’s top 5 cancer centers by U.S. News & World Report, reported that its doctors and scientists will take part in 100 oral and poster presentations, scientific symposia/workshops, education programs and other events at ASH (Free ASH Whitepaper) annual meeting from Dec. 7 to 10 in San Diego (Press release, City of Hope, NOV 21, 2024, View Source [SID1234648564]).
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City of Hope in ASH (Free ASH Whitepaper) Press Program
Two City of Hope researchers will present at ASH (Free ASH Whitepaper) press briefings, and one of its leaders is a senior author on an abstract that will be discussed in the press program as well.
Title: Increased Fiber Intake Results in Better Overall Survival and Lower GI-aGVHD in Allo-HCT Recipients and Pre-Clinical Gvhd Models
Oral Abstract Number: 259
Press Briefing Date/Time and Embargo Lift Time: Saturday, Dec. 7, 7:15 a.m. PST
Presenter: Jenny Paredes, Ph.D., City of Hope staff scientist, who will also receive an ASH (Free ASH Whitepaper) Outstanding Abstract Achievement Award for this research
Title: A High-Fiber Dietary Intervention (NUTRIVENTION) in Precursor Plasma Cell Disorders Improves Biomarkers of Disease and May Delay Progression to Myeloma
Oral Abstract Number: 671
Press Briefing Date/Time and Embargo Lift Time: Saturday, Dec. 7, 7:15 a.m. PST
City of Hope Senior Author: Marcel van den Brink, M.D., Ph.D., president, City of Hope Los Angeles/City of Hope National Medical Center and Deana and Steve Campbell Chief Physician Executive Distinguished Chair in Honor of Alexandra Levine, M.D.
Title: Epcoritamab Monotherapy in Patients (Pts) with Relapsed or Refractory (R/R) Chronic Lymphocytic Leukemia (CLL): Results from CLL Expansion and Optimization Cohorts of Epcore CLL-1
Oral Abstract Number: 883
Press Briefing Date/Time and Embargo Lift Time: Sunday, Dec. 8, 8 a.m. PST
Presenter: Alexey Danilov, M.D., Ph.D., City of Hope Marianne and Gerhard Pinkus Professor in Early Clinical Therapeutics, and associate director, Toni Stephenson Lymphoma Center
City of Hope ASH (Free ASH Whitepaper) Oral Presentations
In addition, City of Hope doctors will present 22 oral abstracts with the following highlights:
Title: 980 Results From the First Phase 1 Clinical Study of DR-01, a Non-Fucosylated Anti-CD94 Targeting Antibody in Patients With Relapsed/Refractory Cytotoxic Lymphomas: Dose Escalation and Optimization
Session Date and Time: Monday, Dec. 9, 4:45 p.m. PST
Presenter: Jasmine Zain, M.D., City of Hope professor, Division of Lymphoma, and director, T Cell Lymphoma Program
Title: 468 Randomized Phase 2 Trial of the Anti-PD-L1 Monoclonal Antibody Durvalumab Plus Lenalidomide Versus Single-Agent Durvalumab in Patients With Refractory/Advanced Cutaneous T Cell Lymphoma
Session Date and Time: Sunday, Dec. 8, 10:45 a.m. PST
Presenter: Christiane Querfeld, M.D., Ph.D., City of Hope professor, Division of Dermatology, and director, Cutaneous Lymphoma Program
Title: 211 Updated Results and Longer Follow-Up From the AUGMENT-101 Phase 2 Study of Revumenib in All Patients With Relapsed or Refractory (R/R) KMT2Ar Acute Leukemia
Session Date and Time: Saturday, Dec. 7, 2 p.m. PST
Presenter: Ibrahim Aldoss, M.D., City of Hope associate professor, Division of Leukemia, Department of Hematology & Hematopoietic Cell Transplantation
Title: 524 Real-World Outcomes of CD19CAR T Cell Therapy in Adult Patients With Relapsed Refractory Transformed Indolent Lymphoma
Session Date and Time: Sunday, Dec. 8, 9:45 a.m.
Presenter: Swetha Kambhampati Thiruvengadam, M.D., City of Hope assistant professor, Division of Lymphoma, Department of Hematology & Hematopoietic Cell Transplantation
Title: 210 Disrupting Mitochondrial Dynamics and Metabolism in Leukemic Stem Cells through Mitochondrial PCNA Inhibition: The Role of AOH1996
Session Date and Time: Saturday, Dec. 7, 3:15 p.m. PST
Presenter: Hyunjun Kang, Ph.D., City of Hope staff scientist, Department of Hematologic Malignancies Translational Science
Title: 1043 Final Analysis of Phase 2a Study of Adding Itacitinib to Tacrolimus/Sirolimus Gvhd Prophylaxis After Fludarabine/Melphalan-Based Conditioning Hematopoietic Cell Transplantation for Acute Leukemias, Myelodysplastic Syndrome (MDS), or Myelofibrosis (MF)
Session Date and Time: Monday, Dec. 9, 5:30 p.m. PST
Presenter: Haris Ali, M.D., City of Hope associate professor, Division of Leukemia, Department of Hematology & Hematopoietic Cell Transplantation, and section leader, Myeloproliferative Neoplasms Program
Title: 966 CD19-CAR T Cells As Definitive Consolidation for Older Adults With B-Cell Acute Lymphoblastic Leukemia in First Complete Remission: A Pilot Study
Session Date and Time: Monday, Dec. 9, 5:45 p.m. PST
Presenter: Ibrahim Aldoss, M.D., City of Hope associate professor, Division of Leukemia, Department of Hematology & Hematopoietic Cell Transplantation
Title: 685 The Composite Health Risk Assessment Model (CHARM) Predicts Risks of Toxicities, Functional and Cognitive Decline Among Survivors of Allogeneic Hematopoietic Cell Transplantation (allo-HCT): A Prospective BMT-CTN Study 1704
Session Date and Time: Sunday, Dec. 8, 4:30 p.m. PST
Senior Author: Andrew Artz, M.D., M.S., City of Hope professor, Division of Leukemia, Department of Hematology & Hematopoietic Cell Transplantation, and director, Aging and Blood Cancers Program
City of Hope doctors will also lead in the following ASH (Free ASH Whitepaper) events:
The 13th Annual BMT & Cell Therapy Winter Workshop, co-chaired by Dr. Van den Brink, will be held on Friday, Dec. 6, 2024, prior to the ASH (Free ASH Whitepaper) conference. The workshop focuses on innovative research pertinent to hematopoietic stem cell transplantation and cell therapy.
Dr. Van den Brink will also speak at a scientific symposium titled "Placing the Brakes on Accelerated Aging" about targeting rejuvenation therapies to decelerate aging on Monday, Dec. 9, 2024.
Jianjun Chen, Ph.D., Simms/Mann Family Foundation Chair in Systems Biology, will speak at a scientific workshop titled "Therapy Resistance Mechanisms in Blood Malignancies Program" about RNA modification and therapy resistance in acute leukemia on Friday, Dec. 6, 2024.