On October 4, 2024 Carisma Therapeutics Inc. (Nasdaq: CARM) ("Carisma" or the "Company"), a clinical-stage biopharmaceutical company focused on discovering and developing innovative immunotherapies, reported its upcoming poster presentations at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper), taking place in Houston, Texas, November 6 -10, 2024 (Press release, Carisma Therapeutics, OCT 4, 2024, View Source [SID1234647040]).

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Details on the poster presentations at SITC (Free SITC Whitepaper) 2024 are below:

Title: Pre-clinical efficacy of a novel anti-GPC3 in vivo CAR-M for hepatocellular carcinoma
Publication Number: 329
Session Date & Time: Friday, Nov. 8, 2024
Location: Exhibit Halls A B George R. Brown Convention Center

Title: A Phase 1, First-in-Human study of autologous monocytes engineered to express an anti-HER2 chimeric antigen receptor (CAR) in participants with HER2 overexpressing solid tumors
Publication Number: 659
Session Date & Time: Friday, Nov. 8, 2024
Location: Exhibit Halls A B George R. Brown Convention Center

The posters presented at SITC (Free SITC Whitepaper) 2024 will be available online in the "Publications" section of Carisma’s website at View Source following the start of the poster session.

On October 4, 2024 Antengene Corporation Limited ("Antengene", SEHK: 6996.HK), a leading innovative, commercial-stage global biopharmaceutical company dedicated to discovering, developing and commercializing first-in-class and/or best-in-class medicines for cancer, reported that it will present three programs at the 2024 Society of Immunology in Cancer Annual Meeting (SITC 2024) to be held in Houston from November 6-10, 2024 (Press release, Antengene, OCT 4, 2024, View Source [SID1234647039]).

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Details of Poster Presentations:

ATG-201 (CD19 x CD3 T-cell Engager)
Title: ATG-201, a novel "2+1" CD19-targeted T-cell Engager (TCE) for the treatment of B cell malignancies and B cell related autoimmune diseases
Abstract Number: 1067
Poster Abstract Presentation at the SITC (Free SITC Whitepaper) Immune Engineering Workshop
Date: November 7, 2024
Time: 3:10 PM – 5:00 PM (Central Standard Time)
5:10 AM – 7:00 AM, Nov 8, 2024 (Beijing Time)
Poster Presentation at the SITC (Free SITC Whitepaper) 39th Annual Meeting
Date: November 8, 2024
Time: 9:00 AM – 7:00 PM (Central Standard Time)
11:00 PM, Nov 8 – 9:00 AM, Nov 9, 2024 (Beijing Time)

ATG-107 (FLT3 x CD3 T-cell Engager)
Title: ATG-107, a novel "2+1" CD3-based T-cell Engager (TCE) targeting FLT3, demonstrates potent preclinical efficacy for the treatment of AML
Abstract Number: 1068
Poster Abstract Presentation at the SITC (Free SITC Whitepaper) Immune Engineering Workshop
Date: November 7, 2024
Time: 3:10 PM – 5:00 PM (Central Standard Time)
5:10 AM – 7:00 AM, Nov 8, 2024 (Beijing Time)
Poster Presentation at the SITC (Free SITC Whitepaper) 39th Annual Meeting
Date: November 9, 2024
Time: 9:00 AM – 8:30 PM (Central Standard Time)
11:00 PM, Nov 9 – 10:30 AM, Nov 10, 2024 (Beijing Time)

ATG-106 (CDH6 x CD3 T-cell Engager)
Title: ATG-106, a novel "2+1" format CDH6-targeted T-cell Engager (TCE), shows potent T cell dependent cytotoxicity and in vivo anti-tumor efficacy
Abstract Number: 1069
Poster Presentation at the SITC (Free SITC Whitepaper) 39th Annual Meeting
Date: November 8, 2024
Time: 9:00 AM – 7:00 PM (Central Standard Time)
11:00 PM, Nov 8 – 9:00 AM, Nov 9, 2024 (Beijing Time)

About the AnTenGager Platform

The AnTenGager Platform is a proprietary "2+1" T cell engager (TCE) platform developed by Antengene. AnTenGager TCE simultaneously binds to disease-associated antigens (targets) and a unique conformational epitope on CD3 that expressed on T-cells. The bivalent binding to the targets enables detection and depletion of cells with low expression of the targets. In addition, AnTenGager TCE activates T cells in a target-dependent manner so that it demonstrates a lower risk of systemic CD3 activation and cytokine release syndrome (CRS), potentially paving the way for their use in autoimmune diseases, hematological malignancies, and solid tumors.

Our extensive and diverse pipeline features promising TCEs that aim to address unmet medical needs in autoimmune diseases and hematology/oncology, with best-in-class/first-in-class potential. A few of our lead programs in the IND-enabling stage include ATG-201, a CD19 x CD3 TCE for B cell related autoimmune diseases; ATG-102, a LILRB4 x CD3 TCE for acute myeloid leukemia (AML) and chronic myelomonocytic leukemia; ATG-106, a CDH6 x CD3 TCE for ovarian cancer and kidney cancer; ATG-107, a FLT3 x CD3 TCE for AML; and ATG-110, a LY6G6D x CD3 TCE for microsatellite stable (MSS) colorectal cancer.

On October 4, 2024 Candel Therapeutics, Inc. (Candel or the Company) (Nasdaq: CADL), a clinical-stage biopharmaceutical company focused on developing multimodal biological immunotherapies to help patients fight cancer, reported the Company will present a poster at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)’s (SITC) (Free SITC Whitepaper) 39th Annual Meeting taking place November 6-10, 2024 in Houston, Texas and virtually (Press release, Candel Therapeutics, OCT 4, 2024, View Source [SID1234647038]).

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Presentation details are as follows:

Title: Therapeutic potential of CAN-3110 in Ras-Raf pathway altered melanoma
Presenter: Anne Diers, PhD, Senior Director, Research, Candel Therapeutics
Abstract Number: 995
Session Date: Friday, Nov. 8, 2024
Location: Exhibit Halls A and B – George R. Brown Convention Center

Further details from the presentation will be available following the events on the Candel website at: View Source

About CAN-3110

CAN-3110 is a first-in-class, replication-competent herpes simplex virus-1 (HSV-1) oncolytic viral immunotherapy candidate designed with dual activity for oncolysis and immune activation in a single therapeutic. Its activity is designed to be conditional to the expression of Nestin in cancer cells. CAN-3110 is being evaluated in a phase 1b clinical trial in patients with recurrent high-grade glioma (rHGG). In October 2023, the Company announced that Nature published results from this ongoing clinical trial. CAN-3110 was well tolerated with no dose-limiting toxicity reported. In the clinical trial, the investigators observed improved median overall survival compared to historical controls after a single CAN-3110 injection in this therapy-resistant condition.1 The Company and academic collaborators are currently evaluating the effects of multiple CAN-3110 injections in rHGG, supported by the Break Through Cancer Foundation. CAN-3110 has previously received FDA Fast Track Designation and Orphan Drug Designation for the treatment of rHGG.

On October 4, 2024 Cue Biopharma, Inc. (Nasdaq: CUE), a clinical-stage biopharmaceutical company developing a novel class of therapeutic biologics to selectively engage and modulate disease-specific T cells, reported it will deliver an oral and a poster presentation on the company’s Immuno-STAT clinical assets CUE-101 and CUE-102, representative of the CUE-100 series, at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper)’s 39th Annual Meeting (SITC 2024) (Press release, Cue Biopharma, OCT 4, 2024, View Source [SID1234647037]). The conference will be held in Houston, Texas, on November 6-10, 2024.

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Presentation Details
Title: A phase 1 dose-escalation and expansion study of CUE-101 as monotherapy and in combination with pembrolizumab in patients with recurrent/metastatic HPV16+ head and neck squamous cell cancer
Abstract Number: 649
Presenter: Dr. Christine Chung, Department Chair, Head and Neck Oncology, Moffitt Cancer Center
Session: Rapid Oral-Clinical 1
Date and Time: Friday, November 8, 2024, 12:30 p.m.–1:30 p.m. CST

Title: A phase 1 trial of CUE-102, a novel WT1-pHLA-IL2-Fc T cell engager in HLA-A*0201 positive patients with WT1-positive recurrent/metastatic cancers
Abstract Number: 636
Presenter: Dr. Dae Won Kim, Moffitt Cancer Center
Session: Poster Session, Exhibit Halls A B George R. Brown Convention Center
Date and Time: Saturday, November 9, 2024, 9:00 a.m.–8:30 p.m. CST

All posters will be available to conference attendees as virtual e-posters on the virtual meeting platform on November 7, 2024, at 9 a.m. CST through January 7, 2025. The oral presentation and poster will also be available on November 8, 2024, in the Investor & Media section of the Company’s website at www.cuebiopharma.com, under Scientific Publications and Presentations.

On October 4, 2024 Oxcia reported that it has chosen to re-prioritize the clinical development of OXC-101 from solid tumors to hematological cancers, specifically acute myeloid leukemia (AML) (Press release, Oxcia, OCT 4, 2024, View Source;utm_medium=rss&utm_campaign=oxcia-is-focusing-the-development-of-oxc-101-on-hematological-cancers [SID1234647036]). The preclinical program for OXC-101 has shown good results in both AML and other forms of hematological cancers, and data to date from the phase I/II study MAATEO confirm the previous results. Oxcia has initiated an expansion part of the MAATEO study in patients with refractory/relapsed AML (R/R AML), where OXC-101 is administered in combination with idarubicin (an anthracycline).

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– The first AML patient to be treated with OXC-101 in an innovative combination treatment has recently been recruited, which is very exciting, says Oxcia’s CEO Ulrika Warpman Berglund. We aim to accelerate patient recruitment, for instance by including more study centers in AML, e.g. Rigshospitalet in Copenhagen. We are also working on an ODD (Orphan Drug Designation) application.

Biostock has today published an article describing Oxcia’s investment in AML and IPF, see Oxcias vd om satsningen på AML och lungfibros – BioStock (Oxcia’s CEO on the investment in AML and pulmonary fibrosis – BioStock – only available in Swedish)

Until now, OXC-101 has also been evaluated in the MASTIFF study, a phase I/II study in severely ill patients with an expansion group focused on advanced ovarian cancer and prostate cancer. OXC-101 demonstrated a clear clinically relevant effect, halting cancer growth in a majority of patients. At the same time, some patients suffered dose-limiting side effects in the form of neutropenia.

– Neutropenia means a decrease in neutrophil granulocytes, a type of white blood cell that is important for the immune system. We are now conducting preclinical studies to better understand these mechanisms. Next, we will investigate which doses, indications and patient groups we could proceed with in solid tumors. However, the focus of Oxcia’s development is on AML emphasizes CEO Ulrika Warpman Berglund.