On September 26, 2024 ChromaDex Corp. (NASDAQ:CDXC), the global authority on nicotinamide adenine dinucleotide (NAD+) with a focus on healthy-aging research, reported that Rob Fried, CEO of ChromaDex and Founder of Tru Niagen, will participate in a fireside chat moderated by Sean McGowan, Senior Analyst at Roth Capital Partners, at the Lytham Partners Fall 2024 Investor Conference (Press release, ChromaDex, SEP 26, 2024, View Source [SID1234646874]). Wesley Yu, Vice President of Finance at ChromaDex, and Mr. Fried will also host virtual one-on-one meetings with investors.

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Company Webcast

The webcasted fireside chat will take place at 1:15 PM ET on Tuesday, October 1, 2024. The webcast can be accessed at View Source or on the Company’s website at chromadex.com. The webcast will also be available for replay following the event.

1×1 Meetings

Mr. Fried and Mr. Yu will participate in virtual one-on-one meetings throughout the event. To arrange a meeting with management, please contact Lytham Partners at 1×[email protected] or register for the event at View Sourceinvreg" target="_blank" title="View Sourceinvreg" rel="nofollow">View Source .

Further information on the conference is available at View Source .

For additional information on ChromaDex, visit www.chromadex.com.

On September 25, 2024 Allarta reported that its CEO Dr. Harald Stover will be presenting at the 2024 Cell and Gene Meeting on the Mesa (Press release, Allarta Life Science, SEP 25, 2024, View Source [SID1234647013]). He will be discussing Allarta’s hydrogel encapsulation to protect transplanted cells and highlighting Allarta’s work to enable a curative therapy for T1D as well as our transformative Cryogels to aid transport and storage.

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Presentation: October 7, 2024 @ 2:30pm MST
Location: Arizona Biltmore, Ballroom G

On September 25, 2024 ExThera Medical reported the completion of the Phase I OSCAR I STUDY (ONCObind CTC Removal Study NCT) at OU Health Stephenson Cancer Center, the clinical partner of the University of Oklahoma (Press release, ExThera Medical, SEP 25, 2024, View Source [SID1234646870]). The OSCAR study is a Prospective Single-Arm Feasibility Trial to evaluate the initial safety and signals of efficacy by determining the ability of the ONCObind Procedure Hemoperfusion Filter to remove Circulating Tumor Cells (CTCs) from the blood of patients with metastatic Pancreatic Ductal Adenocarcinoma (PDAC).

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A total of five patients with PDAC have completed the ONCObind Procedure with no safety concerns or signals that have been observed. Data has subsequently been submitted to the FDA for review and approval, in order to proceed to the second phase of the feasibility trial (OSCAR II), with a proposal for expanding the patient population to include Metastatic Colorectal Cancer (MCRC), in addition to metastatic PDAC.

"We are happy to report that the ONCObind Procedure was well tolerated by all patients," said ExThera Medical Chairman and President Bob Ward, Ph.D., NAE. "We were also pleased by the rapid reduction in patients’ sedimentation rates and their noticeable improvement in appetite."

Sanja Ilic, M.D., M.S., RAC and the chief regulatory officer for ExThera, added, "We have a great partnership with the team at Stephenson Cancer Center and look forward to partnering with them on future pancreatic cancer studies, with the potential to expand into colorectal cancer."

The ONCObind Procedure Hemoperfusion Filter is the product brand name for the Onco-Seraph platform technology, an extracorporeal blood filtration procedure designed to target and filter out CTCs from the bloodstream of patients. CTCs are shed from primary tumors and contribute to metastasis, which is responsible for most cancer-related deaths. The ONCObind Procedure uses a blood filter based on ExThera’s Seraph 100 Microbind Affinity Blood Filter technology, which has shown significant success in reducing CTCs in a recent in vitro study. Both the ONCObind Procedure Hemoperfusion Filter and the Seraph 100 Microbind Affinity Blood Filter are investigational medical devices in the United States and are not approved by the U.S. Food and Drug Administration for sale or distribution.

On September 25, 2024 Amphera B.V., a late-stage biotechnology company developing MesoPher cell therapy to treat cancer, reported publication of the results of a phase II trial in resected pancreatic cancer (REACTIVE) in the Journal of Clinical Oncology (JCO) (Press release, Amphera, SEP 25, 2024, View Source [SID1234646869]).

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Highlights from the REACTIVE trial in resected pancreatic cancer:

The phase II trial, including 38 patients with resected pancreatic cancer who had completed standard-of-care chemotherapy, met the primary endpoint demonstrating a clinically significant increase in 2-year recurrence-free survival of 64% compared to an expected 40%. This was accompanied with only low grade side effects.
The 2-year overall survival rate was 83%. Translational immune-profiling supports an induction of an effective immune-activation against the tumor.
Patients in the REACTIVE trial received 3 bi-weekly injections of Amphera’s MesoPher dendritic cell therapy and booster injections at 4 and 7 months.
Prof Casper van Eijck, pancreatic cancer surgeon, Erasmus MC in Rotterdam and Principal Investigator of the REACTIVE trial said: "These results are promising as recurrence rates are high and long-term survival is rare in this patient group. We are now preparing a randomized phase II/III trial to replicate this efficacy signal. I am happy to announce that the DPCG, the Dutch Pancreatic Cancer Group, one of the world’s leading research groups in this field, has committed to participate in this trial."

Ilona Enninga, COO of Amphera added "We have created a promising cell therapy bridgehead. MesoPher is derisked as to safety and manufacturing. This trial shows that MesoPher induces a clinically meaningful immune response, causing an increase in patient survival. EMA has granted MesoPher Orphan Designation for pancreatic cancer, based on potential significant benefit. We are very happy to announce today that the FDA has granted MesoPher Orphan Designation for pancreatic cancer as well."

Rob Meijer, CEO of Amphera said "The potential of MesoPher cell therapy is increasingly recognized in the scientific and regulatory community. The JCO publication will certainly help us to realize the necessary funding and partners for our next step: a randomized trial in resected pancreatic cancer."

On September 25, 2024 Orion Corporation and Aitia, an AI-enabled biotechnology company and the leader in the development and application of Causal AI and "Digital Twins" to discover and develop new drugs, reported that the companies have entered into agreement to create new Gemini Digital Twins to help in the fight against cancer (Press release, Orion, SEP 25, 2024, View Source [SID1234646868]).

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Cancer is a critical global health issue, affecting millions of people worldwide and imposing a significant burden on healthcare systems. In 2022 alone, nearly 20 million new cancer cases were diagnosed, with 10 million lives lost to the disease1. The global cancer burden is projected to rise significantly, with new cases expected to reach 35 million annually by 2050 if current trends continue, driven by population aging and growth. This growing challenge underscores the urgent need for innovative treatments. The collaboration between Orion and Aitia to discover and develop new cancer drugs aims to address this need.

Under the terms of the agreement, Orion and Aitia will work together to focus on translational questions to discover and validate novel drug targets, and to develop drug candidates across multiple oncologic indications through the utilisation of Aitia’s Digital Twins combined with Orion’s pre-clinical and clinical data and expertise. Orion will receive an exclusive option to research, develop, and commercialise products directed against specific novel drug targets identified by Aitia.

In addition, Aitia is eligible to receive certain upfront payments, and development and regulatory milestone payments totalling to more than USD 10 million per drug target, as well as tiered single-digit royalties on sales of products covered by the agreement.

"We are excited to collaborate with Aitia to harness the power of their Gemini Digital Twins and Causal AI technology in the discovery and development of new cancer treatments. Working with them gives us an opportunity to push the boundaries of what’s possible. By leveraging their cutting-edge technology, we aim to unlock deeper insights into the complex biology of cancer, ultimately accelerating the development of novel therapies that could significantly improve patient outcomes," said Outi Vaarala, Senior Vice President, Innovative Medicines and Research & Development at Orion.

"Our collaboration with Orion is particularly exciting as it brings together our Gemini Digital Twins which leverage large quantities of multi-omic patient data and causal AI and simulation with Orion’s deep expertise in oncology drug discovery and development. By creating highly accurate and predictive models of disease, we can uncover previously hidden mechanisms and pathways, accelerating the discovery of new, more effective medicines. This partnership represents a major step forward in our shared mission to bring innovative treatments to patients suffering from cancer," said Colin Hill, CEO and co-founder of Aitia. "We are excited about what the future holds as we continue to push the boundaries of what’s possible in cancer research and treatment. This collaboration is another step forward, and we remain steadfast in our commitment to discovering and developing breakthrough therapies that can offer new hope to patients and their families."