On May 29, 2024 Halia Therapeutics, a clinical-stage biopharmaceutical company pioneering a novel class of small molecule medications designed to combat inflammation, reported that the company will be participating at the upcoming conferences: BIO InternationalConvention taking place June 3-6 in San Diego and at the European Hematology Association (EHA) (Free EHA Whitepaper) 2024 Hybrid Congress taking place June 13-16 in Madrid, Spain (Press release, Halia Therapeutics, MAY 29, 2024, View Source [SID1234643787]).

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This year at the EHA (Free EHA Whitepaper) 2024 Congress, Margit Janat-Amsbury, MD, Ph.D., Chief Medical Officer of Halia will be presenting a poster, entitled "Trial In Progress: Phase II Study of the NLRP3 Inflammasome & Myddosome Inhibitor HT-6184 in Patients with Low or Intermediate Risk Myelodysplastic Syndrome (MDS)". Dr. Amsbury will highlight preliminary data from the ongoing Phase IIa study evaluating the efficacy, safety, and pharmacodynamics of HT-6184 administered in patients with varying diagnosis of MDS.

"We are thrilled to share preliminary results from our Phase II study evaluating our lead asset HT-6184 in MDS patients" said Dr. Amsbury, Chief Medical Officer of Halia Therapeutics. "Initial data are encouraging, and we are confident that we will be able to advance development of HT-6184, bringing a much-needed therapeutic option for those affected by this challenging condition. Our team remains dedicated to advancing this research and exploring the full potential of HT-6184 mediated NLRP3-inhibition for improving patient outcomes across many different therapeutic areas".

David J. Bearss, Ph.D., President and CEO, Jared Bearss, MBA Chief Operating Officer and Margit Janat-Amsbury, MD, Ph.D., Chief Medical Officer, will be available for meetings at BIO 2024 with registered conference attendees. Meetings can be scheduled through the partnering system.

On May 29, 2024 Grey Wolf Therapeutics, a clinical-stage biotechnology company leveraging first-of-its-kind antigen modulation therapies to address the source of immune dysfunction in oncology and autoimmunity, reported that the first clinical data for the company’s lead immuno-oncology candidate, GRWD5769, will be presented at the 2024 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting (Press release, Grey Wolf Therapeutics, MAY 29, 2024, View Source [SID1234643786]). The presented findings will consist of initial data from the company’s ongoing Phase 1/2 clinical trial of the first-in-class ERAP1 inhibitor in a range of solid tumour types. The 2024 ASCO (Free ASCO Whitepaper) Annual Meeting is being held May 31 – June 4, 2024, in Chicago, IL.

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Details of the company’s presentation at the 2024 ASCO (Free ASCO Whitepaper) Annual Meeting are as follows:

Abstract Number: 2589

Title: EMITT-1: Proof-of-mechanism immunopeptidome (ImPD) effects at target PK exposure, in a Phase 1 study of GRWD5769 (a first-in-class inhibitor of Endoplasmic Reticulum Aminopeptidase 1 [ERAP1]) in patients with solid malignancies
Presenting Author: Thomas Lillie, M.D., Ph.D., Chief Medical Officer of Grey Wolf Therapeutics
Poster Session: Development Therapeutics – Immunotherapy
Date/Time: Saturday, June 1, 2024, 9:00 a.m. Central Time
Location: Poster Hall – Hall A

Grey Wolf has developed and is advancing a unique immune-oncology therapeutic strategy utilizing a proprietary antigen modulation strategy to reveal novel and potent cancer antigens on the surface of tumour cells. This is achieved through oral delivery of a targeted inhibitor of the endoplasmic reticulum aminopeptidases (ERAP1 or ERAP2), key proteins in the antigen presentation pathway. The targeted inhibition of ERAP is designed to elicit a de novo T cell response against tumours and to avoid T-cell exhaustion, thereby overcoming two key resistance mechanisms to current immuno-oncology therapy. The company is conducting an ongoing adaptive Phase 1/2 clinical trial of GRWD5769, which is evaluating the safety, tolerability, and efficacy of GRWD5769, including a planned combination with the PD-1 inhibitor Libtayo (cemiplimab), in a range of solid tumour types.

The company recently reported that it is expanding the scope of the Phase 1/2 trial, allowing for the enrolment of patients with additional tumour types. Additionally, the company has also recently initiated dosing in the study’s first combination treatment cohort.

On May 29, 2024 GlycoMimetics, Inc. (Nasdaq: GLYC) a late clinical-stage biotechnology company discovering and developing glycobiology-based therapies for cancers and inflammatory diseases, reported that it will host a key opinion leader event on Tuesday, June 4, 2024, at 8:30am ET to provide a comprehensive overview of data from the company’s pivotal Phase 3 study of uproleselan in relapsed/refractory (R/R) acute myeloid leukemia (AML) (Press release, GlycoMimetics, MAY 29, 2024, View Source [SID1234643784]).

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The event will feature the study’s principal investigator Daniel DeAngelo, M.D., Ph.D., Professor of Medicine, Harvard Medical School, and Chief of the Division of Leukemia, Dana-Farber Cancer Institute, who will discuss results from the pivotal Phase 3 study of uproleselan, along with the current AML treatment landscape and unmet patient need.

To access the event by phone, please go to this registration link to obtain the dial in details. Participants are encouraged to connect 15 minutes in advance of the scheduled start time.

A live webcast of the call will be available on the "Investors" tab on the GlycoMimetics website. A webcast replay will be available for 30 days following the call.

On May 29, 2024 Fusion Pharmaceuticals Inc. (Nasdaq: FUSN), a clinical-stage oncology company focused on developing next-generation radioconjugates (RCs) as precision medicines, reported that at a special meeting of its shareholders (the "Shareholders"), held virtually earlier today, the Shareholders voted in favour of the resolution to approve the previously announced plan of arrangement with a wholly-owned subsidiary of AstraZeneca under the Canada Business Corporations Act pursuant to which AstraZeneca will acquire all of the issued and outstanding shares of Fusion (the "Arrangement") (Press release, Fusion Pharmaceuticals, MAY 29, 2024, View Source [SID1234643782]).

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As of the close of business on April 16, 2024, the record date of the special meeting, there were approximately 84,965,608 shares issued and outstanding and entitled to vote. A total of 68,678,602 shares were voted at the special meeting representing approximately 80.83% of the issued and outstanding shares as of the record date.

The Arrangement was approved, receiving the required affirmative vote of (i) 99.92% of the votes cast by the Shareholders, voting as a single class, present in person or represented by proxy and entitled to vote at the special meeting and (ii) 99.92% of the votes cast by the Shareholders, present in person or represented by proxy and entitled to vote at the special meeting, after excluding the votes of those Shareholders whose votes are required to be excluded under Multilateral Instrument 61-101—Protection of Minority Security Holders in Special Transactions.

The formal report on voting results with respect to all matters voted upon at the meeting will be filed under Fusion’s profile on SEDAR+ at www.sedarplus.com.

The arrangement is subject to court approval, as well as other customary closing conditions. Subject to the satisfaction of such conditions, the transaction is expected to be completed in the second quarter of 2024.

On May 29, 2024 CRISPR Therapeutics (Nasdaq: CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, reported that members of its senior management team are scheduled to participate in the following investor conferences in June (Press release, CRISPR Therapeutics, MAY 29, 2024, View Source [SID1234643781]).

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Jefferies Healthcare Conference
Date: Wednesday, June 5, 2024
Time: 10:00 a.m. ET

Goldman Sach’s 45th Annual Global Healthcare Conference
Date: Tuesday, June 11, 2024
Time: 9:20 a.m. ET

A live webcast will be available on the "Events & Presentations" page in the Investors section of the Company’s website at View Source A replay of the webcasts will be archived on the Company’s website for 14 days following the presentation.