On January 3, 2024 Integrated BioTherapeutic Vaccines reported the company changes its name to AbVacc Inc. (Press release, Integrated Biotherapeutics Vaccines, JAN 3, 2023, View Source [SID1234644418]). The mission of AbVacc is to utilize structure-based design for development of next generation vaccines and immunotherapeutics for treatment of infectious and inflammatory diseases. Building upon 15 years of research under the parent company Integrated BioTherapeutics, AbVacc now has a vibrant pipeline of monoclonal antibodies and engineered vaccines in advanced preclinical with several candidate entering the clinical stage in the next few years. To accomplish its ambitious goals, AbVacc has focused on a public-private funding strategy and partnered with various Government funding agencies, primarily National Institute of Allergy and Infectious Diseases (NIAID) and CARB-X as well as private funding sources such as Novo Holdings Repair Impact Fund. Further strategic partnerships include EliteImmune Corp., Scripps Research Institute, La Jolla Institute for Immunology, ViroVax, LLC, University of Texas Medical Branch, Johns Hopkins University, University of Rochester, University of Maryland, and Washington University.

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AbVacc operations will remain at 4 research Court, Suite 310, Rockville, MD.

On January 3, 2023 Blacksmith Medicines reported the company and Forge Therapeutics have signed a definitive merger agreement (Press release, Forge Therapeutics, JAN 3, 2023, View Source [SID1234643527]). This will create a biopharma company dedicated to discovering and developing medicines targeting a large class of proteins called metalloenzymes. The initial focus will be on oncology and infection.

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"We are excited to unveil the merger of Blacksmith and Forge, which we believe will be transformational for both companies. Prospects are very bright for the new Blacksmith, as we are now able to expand our metalloenzyme platform, advance our internal and partnered programs, and create increased value for our shareholders by discovering first-in-class and best-in-class medicines," said Zachary Zimmerman, CEO and co-founder of Blacksmith Medicines.

"Our target strategy is to focus on metalloenzymes of significant unmet need and high pharma interest, targets with validated biology that have been challenging to drug due to chemistry limitations that we can solve with our platform."

The Blacksmith platform has been validated through multiple pharmaceutical partnerships. These include deals with Roche, Eli Lilly, and Basilea, which have the potential to earn more than $800 million in milestone payments plus royalties.

Blacksmith Medicines currently has earned non-dilutive federal awards of up to $25.3 million. This will fully fund its infectious disease programs to the end of phase 1.

Blacksmith Medicines also has emerging precision oncology programs focused on novel synthetic lethality targets involved in the DNA damage response. Blacksmith investors include Evotec A.G., MagnaSci Ventures, MP Healthcare Partners, Alexandria Venture Investments, and Eli Lilly.

About metalloenzymes and the Blacksmith Therapeutics platform
Metalloenzymes utilize a metal ion cofactor in the enzyme active site to perform essential biological functions. This diverse class of targets has historically been difficult to drug due to small molecule chemistry limitations.

The Blacksmith metalloenzyme platform has solved this through a large proprietary fragment library of metal-binding pharmacophores (MBPs); a database containing a full characterization of the metalloenzyme genome including functions, metal cofactors, and associations to disease; and a first-of-its-kind metallo-CRISPR library of custom single guide RNAs.

Blacksmith Medicines also has a metalloenzyme computational toolkit for docking, modeling and structure-based drug design. It also has a blocking intellectual property estate covering bioinorganic, medicinal, and computational chemistry approaches for metalloenzyme-targeted medicines.

On January 3, 2023 Galapagos NV (Euronext & NASDAQ: GLPG) reported that it will participate in the 41th Annual J.P. Morgan Healthcare Conference on January 9-12, 2023 (Press release, Galapagos, JAN 3, 2023, View Source [SID1234625878]).

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Paul Stoffels1, CEO, will present on Monday, January 9 at 4.30 p.m. PST/7.30 p.m. ET (Tuesday, January 10 at 01.30 a.m. CET). The presentation will be a live audio webcast and can be accessed via the following link. A replay of the webcast will be available on the Galapagos’ website at View Source

On January 3, 2023 Sana Biotechnology, Inc. (NASDAQ: SANA), a company focused on creating and delivering engineered cells as medicines, reported that it will webcast its presentation at the 41st Annual J.P. Morgan Healthcare Conference at 3:45 p.m. PT on Tuesday, January 10, 2023 (Press release, Sana Biotechnology, JAN 3, 2023, View Source [SID1234625823]). The presentation will feature a business overview and update by Steve Harr, Sana’s President and Chief Executive Officer.

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The webcast will be accessible on the Investor Relations page of Sana’s website at View Source A replay of the presentation will be available at the same location for 30 days

On January 3, 2023 Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) reported that it will report its fourth quarter and full year 2022 financial and operating results on Friday, February 3, 2023, before the U.S. financial markets open (Press release, Regeneron, JAN 3, 2023, View Source [SID1234625821]). The Company will host a conference call and simultaneous webcast at 8:30 AM Eastern Time that day.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Conference Call Information

Participants may access the conference call live via webcast on the ’Investors and Media’ page of Regeneron’s website at View Source To participate via telephone, please register in advance at this link. Upon registration, all telephone participants will receive a confirmation email detailing how to join the conference call, including the dial-in number along with a unique passcode and registrant ID that can be used to access the call. A replay of the conference call and webcast will be archived on the Company’s website for at least 30 days.