Adicet Bio Announces Poster Presentation at the Upcoming 2023 Molecular Targets and Cancer Therapeutics Conference

On October 4, 2023 Adicet Bio, Inc. (Nasdaq: ACET), a clinical stage biotechnology company discovering and developing allogeneic gamma delta T cell therapies for cancer, reported a poster presentation at the upcoming 2023 AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper) hosted by the American Association for Cancer Research (AACR) (Free AACR Whitepaper), the National Cancer Institute, and the European Organisation for Research and Treatment of Cancer to be held in Boston from October 11-15, 2023 (Press release, Adicet Bio, OCT 4, 2023, View Source [SID1234635664]).

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Details of the poster presentation is as follows:

Abstract Title: Characterization of Allogeneic CAR γδ1 T Cell Therapy for Prostate Cancer Targeting a Novel Dimeric Epitope on PSMA (Prostate-Specific Membrane Antigen)

Poster Number: C117

Presenting Author: Nitya Ramadoss, PhD

Date/Time: Saturday, October 14, from 12:30 p.m. – 4:00 p.m. PDT

Session Location: Level 2, Exhibit Hall D

Boundless Bio Announces Upcoming Presentations at 2023 AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

On October 4, 2023 Boundless Bio, a clinical stage, next-generation precision oncology company interrogating extrachromosomal DNA (ecDNA) biology to deliver transformative therapies to patients with previously intractable oncogene amplified cancers, reported two upcoming poster presentations at the AACR (Free AACR Whitepaper)-NCI-EORTC AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper), taking place from October 11-15, 2023, in Boston, MA (Press release, Boundless Bio, OCT 4, 2023, View Source [SID1234635663]).

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Details of the presentations are as follows:

Title: A novel, potent and selective ribonucleotide reductase (RNR) inhibitor, BBI-825, blocks extrachromosomal DNA (ecDNA) amplification-mediated resistance to KRASG12C inhibitor in colorectal cancer (CRC)
Abstract Number: B082
Session: Poster Session B
Date/Time: Friday, October 13 | 12:30 – 4:00 pm ET

Title: Intrinsic genomic plasticity of extrachromosomal DNA (ecDNA) enables oncogene amplified tumor cells to develop rapid acquired resistance to targeted therapy
Abstract Number: B092
Session: Poster Session B
Date/Time: Friday, October 13 | 12:30 – 4:00 pm ET

Nested Therapeutics to Present Preclinical Data for Novel, Potential Best-in-Class Inhibitor of the RAS/MAPK Pathway at 2023 AACR-NCI-EORTC Conference

On October 4, 2023 Nested Therapeutics, a biotechnology company pioneering a next-generation precision medicine platform to address hard-to-treat cancers, reported that it will present preclinical data from its lead candidate, NST-628, a mechanistically novel non-degrading molecular glue that targets multiple nodes in the RAS/MAPK pathway, at the upcoming 2023 AACR (Free AACR Whitepaper)-NCI-EORTC International Conference taking place in Boston, Massachusetts from October 11 – 15, 2023 (Press release, Nested Therapeutics, OCT 4, 2023, View Source [SID1234635662]).

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Nested Therapeutics will be presenting three posters that validate the mechanism of action and demonstrate potential superiority of NST-628 compared to other MAPK-targeted compounds. Details for the accepted abstracts are listed below.

Title: NST-628 is a novel molecular glue that inhibits signaling and pathway reactivation in oncogenic RAS-MAPK cancers
Session Date and Time: Thursday, October 12, 12:30 – 4 pm, Level 2, Exhibit Hall D, Hynes Convention Center
Abstract Number: A086
Session: Poster Session A

Title: NST-628 is a potent, best-in-class MAPK pathway molecular glue that inhibits RAS- and RAF-driven cancers
Session Date and Time: Thursday, October 12, 12:30 – 4 pm, Level 2, Exhibit Hall D, Hynes Convention Center
Abstract Number: A088
Session: Poster Session A

Title: NST-628 is a potent, fully brain-penetrant, RAS/MAPK pathway molecular glue inhibitor with efficacy in CNS tumor models
Session Date and Time: Thursday, October 12, 12:30 – 4 pm, Level 2, Exhibit Hall D, Hynes Convention Center
Abstract Number: A089
Session: Poster Session A

About DeCRYPTion Platform

Nested Therapeutics’ DeCRYPTion Platform is a purpose-built, insightful drug discovery platform that enables Nested to identify new, overlooked areas of opportunity in the form of high value targets and design therapeutics for a perfect fit. The platform includes three critical components: (1) mapping mutational clusters onto the structural proteome, (2) identifying druggable pockets and cancer-driving mechanisms, and (3) designing novel drugs optimized for the druggable pocket.

Flare Therapeutics to Present Biomarker Data for Clinical Candidate FX-909 at 2023 AACR-NCI-EORTC International Conference

On October 4, 2023 Flare Therapeutics Inc., a biotechnology company targeting transcription factors to discover precision medicines for cancer and other diseases, reported a poster presentation highlighting an artificial intelligence-based model developed in partnership with PathAI that identifies the luminal subtype in Urothelial Carcinoma as a novel biomarker approach for its first-in-class clinical candidate FX-909 at the upcoming 2023 AACR (Free AACR Whitepaper)-NCI-EORTC AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper), taking place October 11-15 in Boston, Massachusetts (Press release, Flare Therapeutics, OCT 4, 2023, View Source [SID1234635661]).

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Details for the poster presentation are as follows:

Abstract Title: AI analysis of histological images accurately identifies luminal subtype urothelial carcinomas characterized by high PPARG expression
Poster Number: B016
Presenter: Stefan Kirov, Vice President, Computational Biology, Flare Therapeutics
Date/Time: Friday, October 13, 2023, from 12:30 to 4:00 p.m. ET
Location: Exhibit Hall D, Hynes Convention Center, Boston

DELFI Diagnostics to Highlight Breakthrough Technology and Completed Clinical Study in Lung Cancer Detection

On October 4, 2023 DELFI Diagnostics, Inc., a developer of accessible blood-based tests that deliver a new way to detect cancer, reported that the company will participate in multiple sessions at the HLTH 2023 conference in Las Vegas, Nevada, and the CHEST 2023 Annual Meeting in Honolulu, Hawai’i, both taking place October 8-11, 2023 (Press release, Delfi Diagnostics, OCT 4, 2023, View Source [SID1234635660]).

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At HLTH, DELFI will share a critical update on the company’s progress developing its lung cancer detection test for screen-eligible individuals, as well as perspectives on the evolving liquid biopsy landscape during a Tech Talk presentation and a panel discussion. DELFI’s approach to early cancer detection applies advanced machine learning technology to whole-genome sequencing data to compare an individual’s cell-free DNA (cfDNA) patterns and characteristics against populations with and without cancer. An oral presentation at CHEST will highlight new data from the DELFI-L101 Study, "DNA Evaluation of Fragments for Early Interception – Lung Cancer Training Study," a prospective, multicenter, case-control study among individuals eligible for lung cancer screening to train and independently validate the blood-based test for early cancer detection.

"Lung cancer is the leading cause of cancer death globally, yet only six percent of the over 15 million Americans who are eligible to be screened annually do so," said Peter B. Bach, M.D., DELFI Chief Medical Officer, who will participate in a HLTH panel on cancer screening. "DELFI is built to solve the highest-burden population health issues, starting with lung cancer. HLTH and CHEST are timely opportunities for us to reveal new insights on and advancements with our accurate, accessible new way to detect cancer in its earliest stages."

DELFI HLTH Events

Convention Center West Hall, Las Vegas, NV

DELFI Tech Talk: A ‘FirstLook’ at DELFI’s New Way to Detect Early Lung Cancer: 1:30-1:40 pm PDT, Monday, October 9, 2023, Tech Talk Stage. Victor Velculescu, M.D., Ph.D., DELFI Founder and Chief Executive Officer, will deliver a science and technology presentation on the company’s lung cancer early detection test.
"To Screen or Not to Screen" Panel: 2:10-2:50 pm PDT, Tuesday, October 10, 2023, Sky Stage. Dr. Bach will share his perspectives on the current landscape of early cancer detection and how DELFI is developing a new solution to address unmet early detection needs on a population-health scale.
Oral Presentation at CHEST
Hawai’i Convention Center, Honolulu, Hawai’i

Prospective Evaluation of Cell-Free DNA Fragmentation Profiles for Lung Cancer Detection: 12:32–12:36 pm HST, Tuesday, October 10, 2023, Rapid Area 2D. As part of the "Updates in Lung Cancer" session, Peter Mazzone, M.D., MPH, Director of the Lung Cancer Program and Lung Cancer Screening Program for the Respiratory Institute at the Cleveland Clinic and the principal investigator for DELFI’s L101 study, will present new data from the study during an oral presentation.