On September 27, 2023 Coeptis Therapeutics Holdings, Inc. (NASDAQ: COEP) ("Coeptis" or "the Company"), a biopharmaceutical company developing innovative cell therapy platforms for cancer, reported that Colleen Delaney, MD, MSc, Chief Scientific and Medical Officer, will present at the 2023 Cell & Gene Meeting on the Mesa being held October 10-12, 2023 in Carlsbad, CA at the Park Hyatt Aviara Resort (Press release, Coeptis Therapeutics, SEP 27, 2023, View Source;gene-meeting-on-the-mesa-301939827.html [SID1234635481]).

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Dr. Delaney will provide an overview of Coeptis’ clinical development programs including the recent Phase 1 safety and dosing update for DVX201 in relapsed/refractory acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) and patients hospitalized with COVID-19 infection. During the conference Dr. Delaney and Dave Mehalick, President and CEO of Coeptis Therapeutics, will be conducting one-on-one investor and strategic partnering meetings.

Details of the presentation are as follows:

Event:

2023 Cell & Gene Meeting on the Mesa

Date & Time:

October 11, 2023 at 4:30 PM, PDT

Location:

Park Hyatt Aviara Resort, Carlsbad, CA, Rentschler ATMP Ballroom

"The Cell & Gene Meeting on the Mesa is a vital annual event bringing together leaders who are tackling the major scientific, logistic, policy, and economic questions confronting the cell therapy industry," said Dr. Delaney. "Coeptis recently announced excellent interim safety results for DVX201 across two trials with distinct patient populations. These early results are extremely encouraging and represents a major step for this first in-human use of an allogeneic NK cell therapy derived from pooled donor CD34+ HSPCs. I look forward to discussing these results with colleagues as well as the innovative and complementary platforms that Coeptis is assembling to develop powerful cell-based treatments to improve outcomes for patients with cancer, while we also strive to universalize cell therapy to enable greater access to these medical breakthroughs."

Virtual attendance is available which includes a livestream of Coeptis’ presentation and the ability to view all conference sessions on-demand. Please visit View Source for full information including registration.

Complimentary attendance at this event is available for credentialed investors and members of the media only. Investors should contact Savannah Bryant at [email protected] and interested media should contact Stephen Majors at [email protected].

On September 27, 2023 HotSpot Therapeutics, Inc., a biotechnology company pioneering the discovery and development of oral, small molecule allosteric therapies targeting regulatory sites on proteins referred to as "natural hotspots," reported that it will present additional preclinical data from the Company’s CBL-B program in a poster presentation at the 2023 Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) Annual Meeting, taking place November 1-5, 2023, in San Diego, CA (Press release, HotSpot Therapeutics, SEP 27, 2023, View Source [SID1234635480]).

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Presentation details are as follows:

Title: Exploring Proximal Biomarkers of CBL-B Inhibition in Human Peripheral Blood Mononuclear Cells
Session Date and Time: Fri., Nov. 3, 9:00 AM-7:00 PM PT
Location: Exhibit Halls A and B1, San Diego Convention Center

Abstract Number: 55

About HST-1011
HST-1011 is an investigational orally bioavailable, selective, small molecule allosteric inhibitor of CBL-B, an E3 ubiquitin protein ligase critically involved in immune cell response. Because CBL-B functions as a master regulator of effector cell (T cell and natural killer cell) immunity, its inactivation removes its endogenous negative regulatory functions to substantially enhance anti-tumor immunity. Preclinical data has demonstrated HST-1011’s ability to bind to and inhibit a natural hotspot on CBL-B, yielding the activation and propagation of a targeted anti-tumor immune response. Enabled by HotSpot’s proprietary Smart Allostery platform, HST-1011 is designed with tight binding, low nanomolar potency, a slow dissociation rate from the target to enable sustained pharmacology, and greater selectivity for CBL-B relative to C-CBL.

On September 27, 2023 Starpax Biopharma Inc., a biopharmaceutical company developing a groundbreaking cancer treatment platform technology, reported the launch of its Regulation A+ capital raise (Press release, Starpax Biopharma, SEP 27, 2023, View Source [SID1234635479]). This raise will provide an opportunity for US accredited and non-accredited investors to participate in the company’s mission to revolutionize cancer treatment.

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Starpax Biopharma Inc., a biopharmaceutical research and development company, has conceived an unprecedented platform technology to treat cancer using living self-propelled Starpax Magnetodrones that are sensitive to magnetic fields, swim within interstitial spaces of tumor tissues, transport anticancer drug attached to their surface, are non-pathogenic and die approximately 60 minutes after injection. The Magnetodrones are injected directly into the tumor and transport an anticancer molecule used in an FDA-approved treatment that has been used on millions of humans for 20 years. The trajectory of the Magnetodrones is controlled by the Starpax PolarTrak in which the patient is positioned, and that is designed to generate precise 3D guidance magnetic field vectors in order to trap the Magnetodrones inside the tumor and force them to spread and release the anticancer drug throughout the volume of the tumor, including hypoxic zones — without circulating in the bloodstream, thereby avoiding side effects usually resulting from systemic cancer treatments.

The proceeds from the Regulation A+ raise will primarily be used for Starpax Biopharma’s ongoing research and clinical trials on humans for six unmet medical need cancer indications in the following organs: pancreas, prostate, head and neck, breast, colorectal and vulva.

Michael Gareau, founding president of Starpax Biopharma, stated, "We are excited to launch our Regulation A+ capital raise, providing an opportunity for a broader range of investors to join us in our mission to change the way cancer is treated. With the support of our investors, we believe that our technology has the potential to improve the lives of millions of patients worldwide."

This investment opportunity offers a unique chance to participate in a never-before-seen technology that aims to change the way cancer is treated.

Investors interested in participating in Starpax Biopharma’s Regulation A+ capital raise can get more information by downloading the offering circular and accessing the investor deck at investinstarpax.com

This press release contains forward-looking statements that are subject to risks and uncertainties. Please consult the offering circular for more information about these risks and uncertainties.

On September 27, 2023 Geneos Therapeutics, a clinical stage biotherapeutics company focused on the development of personalized therapeutic cancer vaccines (PTCV), reported that it has completed its Series A3 financing round with an additional investment of $5 million, totaling $10 million (Press release, Geneos Therapeutics, SEP 27, 2023, View Source [SID1234635478]). This investment adds Shanghai Healthcare Capital (SHC) to Geneos’ investor syndicate. Dr. Jing Bao will join as a board observer, bringing extensive expertise in the pharmaceutical industry and with global clinical trials.

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"We are pleased to add SHC to our investor syndicate and Dr. Bao to our team. The depth of knowledge the SHC team brings as well as their network in China will be invaluable to Geneos, especially as we pursue hepatocellular (liver) cancer as our initial target," stated Niranjan Sardesai, PhD., president and chief executive officer of Geneos Therapeutics.

"The results that Geneos has achieved to date in the clinic with its personalized therapeutic cancer vaccine are impressive, and we are pleased to support Geneos’ further clinical development of this important treatment," stated Jing Bao, MD, partner of SHC.

Proceeds Will Fund Completion of Phase 1b/2a GT-30 Program
GT-30 is evaluating the safety, and efficacy of PTCV (GNOS-PV02 plus plasmid-encoded IL-12) administered in combination with the immune checkpoint inhibitor pembrolizumab, in 36 patients with unresectable or metastatic hepatocellular carcinoma (HCC) who progress on, or are intolerant to, first-line tyrosine kinase inhibitors (sorafenib or lenvatinib). Study enrollment completed in June of this year with the top-line safety and clinical response data from the complete cohort of 36 patients is anticipated by the end of the year. View Source

On September 27, 2023 Nektar Therapeutics (Nasdaq: NKTR) reported that it has entered into a new clinical study collaboration with Cellular Biomedicine Group Inc. ("CBMG") (Press release, Nektar Therapeutics, SEP 27, 2023, View Source [SID1234635477]). The study will evaluate Nektar’s NKTR-255, a novel interleukin-15 (IL-15) receptor agonist, in combination with CBMG’s C-TIL051, a tumor-infiltrating lymphocyte (TIL) therapy, in advanced non-small cell lung cancer (NSCLC) patients that are relapsed or refractory to anti-PD-1 therapy.

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NKTR-255 is a novel polymer-conjugated human IL-15 receptor agonist currently being studied in two separate Phase 2 studies in combination with cell therapies and immunotherapies. Preclinical and early clinical data suggest that IL-15 can improve proliferation and persistence of cellular therapies including TIL, TCR, and CAR-T therapies to increase specific anti-tumor activity.

"Early results have shown that NKTR-255 has the potential to emerge as a valuable adjuvant therapy for a range of cell therapy platforms," said Mary Tagliaferri, M.D., Chief Medical Officer at Nektar Therapeutics. "We are excited to partner with CBMG, a leader in the development of the next generation of cell therapies, to evaluate this novel combination in the clinical setting of lung cancer. Combining NKTR-255 and C-TIL051 could have the potential to deliver deep and durable objective responses with a well-tolerated regimen to patients battling relapsed or refractory NSCLC."

C-TIL051 is an autologous adoptive cell therapy being developed by CBMG that is comprised of a patient’s ex vivo expanded lymphocytes using CBMG’s proprietary manufacturing process. The development of C-TIL051 was based on initial NSCLC TIL studies demonstrating encouraging safety and efficacy results (NCT03215810, NCT03645928). In October of last year, CBMG received clearance of an Investigational New Drug (IND) application for C-TIL051 for late-stage NSCLC patients that are relapsed or refractory to anti-PD-1 therapy.

Under the new collaboration, CBMG will add NKTR-255 to its ongoing CBMG-sponsored Phase 1 clinical trial evaluating C-TIL051 in NSCLC patients who have relapsed on or were refractory to anti-PD-1 therapy, which is being conducted at Duke Cancer Institute (NCT05676749). The study is expected to enroll a total of 20 patients. Nektar will contribute NKTR-255 supply for the study. Nektar and CBMG will each maintain existing global rights to their respective investigational medicines.

About NKTR-255

NKTR-255 is a biologic that targets the IL-15 pathway in order to activate the body’s innate and adaptive immunity. Through optimal engagement of the IL-15 receptor complex, NKTR-255 is designed to enhance functional NK cell populations and formation of long-term immunological memory, which may lead to sustained and durable anti-tumor immune response.

Preclinical and early clinical findings suggest IL-15 can improve proliferation and persistence of cellular therapies including TIL, TCR, and CAR-T therapies to increase specific anti-tumor activity.

NKTR-255 is currently being studied in two separate Phase 2 studies in combination with cell therapies and immunotherapy. A Phase 2/3 study is underway that combines NKTR-255 with approved CAR-T cell therapies in patients with diffuse large B-cell lymphoma, which is currently recruiting (NCT05664217). NKTR-255 is also being studied in a Phase 2 study in combination with avelumab as a maintenance treatment in patients with locally advanced or metastatic urothelial carcinoma in the Merck KGaA-sponsored JAVELIN Bladder Medley trial (NCT05327530), as well as in combination with durvalumab in patients with locally advanced NSCLC in an IST conducted at M.D. Anderson Cancer Center.

In addition, there are two ongoing investigator sponsored trials (ISTs) evaluating NKTR-255 as adjunct therapy following a CAR-T cell therapy. Fred Hutchinson Cancer Center is conducting a Phase 1 study evaluating NKTR-255 following lisocabtagene maraleucel treatment in patients with relapsed/refractory large B-cell lymphoma (NCT05359211), and Stanford University is conducting a Phase 1 study evaluating NKTR-255 following an investigational CD19/22 CAR-T cell therapy in patients with relapsed or refractory B-cell acute lymphoblastic leukemia (NCT03233854).