Company Overview

On June 7, 2023 Eagle Pharmaceuticals presented its corporate presentation (Presentation, Eagle Pharmaceuticals, JUN 7, 2023, View Source [SID1234632554]).

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BeyondSpring and Leading Cancer Center Present Poster Highlighting Plinabulin’s Ability to Reduce Infectious Neutropenic Fever for Multiple Myeloma Patients Undergoing AHCT

On June 7, 2023 BeyondSpring Inc. (NASDAQ: BYSI) ("BeyondSpring" or the "Company"), a global clinical-stage biopharmaceutical company focused on using a groundbreaking technology platform for drug discovery and developing innovative therapies to improve clinical outcomes for patients with high unmet medical needs, reported new data from a Phase 1 investigator initiated study highlighting a reduction in chemotherapy-induced infectious neutropenic fever with lead asset Plinabulin in combination with pegfilgrastim in multiple myeloma (MM) patients who underwent autologous hematopoietic stem cell transplantation (AHCT) and received a high dose of melphalan, a type of chemotherapy and one of the most active treatments for MM (NCT05130827) (Press release, BeyondSpring Pharmaceuticals, JUN 7, 2023, View Source;utm_medium=rss&utm_campaign=beyondspring-and-leading-cancer-center-present-poster-highlighting-plinabulins-ability-to-reduce-infectious-neutropenic-fever-for-multiple-myeloma-patients-undergoing-ahct [SID1234632552]). BeyondSpring and Memorial Sloan Kettering Cancer Center (MSK) presented the data at the 2023 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting.

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Between January 2022 and February 2023, 15 patients with a median age of 64 received Plinabulin after a high dose of melphalan. One dose of 40mg of Plinabulin was given to patients via IV infusion one to three hours after stem cell infusion on Day 0, and 6mg of pegfilgrastim was given on Day 1.

The Plinabulin and pegfilgrastim combination appears well tolerated without additional major toxicities post AHCT. Although the combination did not decrease days of severe neutropenia compared with historical data of pegfilgrastim alone, the addition of Plinabulin potentially decreased other clinical consequences:

Reduced rate of infection-related neutropenic fever: Out of 15 patients, 7 had no fevers and 1 had a true neutropenic fever;
Reduced red blood cell (RBC) transfusion: Median of zero RBC transfusion per patient with the use of Plinabulin and pegfilgrastim;
Reduced platelet transfusion: Median of two platelet transfusions per patient with the combination.
"The Plinabulin-pegfilgrastim combination represents a new potential supportive care for MM patients undergoing AHCT. From this pilot study, we saw a trend in the combination in reducing infectious neutropenic fevers and RBC and platelet transfusion requirements compared to historical expectations, which are clinically important benefits." said Dr. Gunjan Shah, MD, MS, Assistant Attending Physician at MSK and Principal Investigator of the trial.

Atara Biotherapeutics to Participate in the Goldman Sachs 44th Annual Global Healthcare Conference

On June 7, 2023 Atara Biotherapeutics, Inc. (Nasdaq: ATRA), a leader in T-cell immunotherapy, leveraging its novel allogeneic Epstein-Barr virus (EBV) T-cell platform to develop transformative therapies for patients with cancer and autoimmune diseases, reported that Pascal Touchon, President and Chief Executive Officer, will participate in a fireside chat at the Goldman Sachs 44th Annual Global Healthcare Conference on Wednesday, June 14, 2023 at 4:00 p.m. PDT / 7:00 p.m. EDT (Press release, Atara Biotherapeutics, JUN 7, 2023, View Source [SID1234632551]).

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A live webcast of the presentation will be available by visiting the Investors and Media section of atarabio.com. An archived replay of the webcast will be available on the Company’s website for 30 days following the live presentation.

Ascendis Pharma to Participate in the Goldman Sachs 44th Annual Global Healthcare Conference

On June 7, 2023 Ascendis Pharma A/S (Nasdaq: ASND) reported that Jan Mikkelsen, President & Chief Executive Officer, and Scott Smith, Executive Vice President & Chief Financial Officer, will participate in a fireside chat at the Goldman Sachs 44th Annual Global Healthcare Conference on Tuesday, June 13 (Press release, Ascendis Pharma, JUN 7, 2023, View Source [SID1234632550]).

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Details:

Event Goldman Sachs 44th Annual Global Healthcare Conference
Location Dana Point, CA
Date Tuesday, June 13, 2023
Time 12:20 p.m. Eastern Time / 9:20 a.m. Pacific Time
A live webcast of the event will be available via the Investors & News section of the Ascendis Pharma website at View Source A webcast replay will also be available on this website shortly after conclusion of the event for 30 days.

Akoya Biosciences Announces Public Offering of Common Stock

On June 7, 2023 Akoya Biosciences, Inc. (Nasdaq: AKYA) ("Akoya"), The Spatial Biology Company, reported that it has launched an underwritten public offering of shares of its common stock (the "Offering") (Press release, Akoya Biosciences, JUN 7, 2023, View Source [SID1234632549]). In addition, Akoya expects to grant the underwriters a 30-day option to purchase additional shares of its common stock. The proposed offering is subject to market and other conditions, and there can be no assurance as to whether or when the offering may be completed, or as to the actual size or terms of the offering.

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Akoya intends to use the net proceeds from the Offering for working capital and general corporate purposes.

Morgan Stanley and Piper Sandler, are acting as joint book-running managers for the Offering.

The securities described above are being offered by Akoya pursuant to a shelf registration statement on Form S-3 that was filed with the U.S. Securities and Exchange Commission (the "SEC") and was declared effective on November 21, 2022. A preliminary prospectus supplement and the accompanying prospectus relating to the Offering will be filed by Akoya with the SEC and will be available on the SEC’s website at www.sec.gov. A final prospectus supplement and the accompanying prospectus relating to the Offering will be filed by Akoya with the SEC. The Offering will be made only by means of a prospectus, including a prospectus supplement, that forms part of the registration statement referred to above. Copies of the preliminary prospectus supplement and the accompanying prospectus relating to the Offering may be obtained by contacting: Morgan Stanley & Co. LLC, Attention: Prospectus Department, 180 Varick Street, 2nd Floor, New York, New York 10014, by phone at 1-866-718-1649 or by email at [email protected] and Piper Sandler & Co., Attention: Prospectus Department, 800 Nicollet Maill J12S03, Minneapolis, Minnesota 55402, by telephone at 1-800-747-3924 or by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation, or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.