On May 3, 2023 Photocure ASA (Photocure) (PHO: OSE) reported that it will announce the first quarter 2023 financial results on Wednesday 10 May 2023 at 08:00 CEST and will present a live webcast at 14:00 CEST the same day (Press release, PhotoCure, MAY 3, 2023, View Source [SID1234630952]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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The quarterly report and presentation will be published at 08:00 CEST and will be publicly available at www.photocure.com.

The investor presentation will be streamed live and be hosted by Dan Schneider, CEO and Erik Dahl, CFO. The presentation will be held in English and questions can be submitted throughout the event. The presentation is scheduled to conclude at 14:45 CEST.

The streaming event is available through https://channel.royalcast.com/landingpage/hegnarmedia/20230510_9/.

On May 3, 2023 KaliVir Immunotherapeutics, Inc., a biotech company developing cutting-edge, multi-therapeutic oncolytic viral immunotherapy programs, reported that its Director of Immunology, Ravikumar Muthuswamy, Ph.D., will present "Novel Oncolytic therapy VET3-TGI restricts TGFβ1 and augments Type-1 immune response in TME, leading to superior therapeutic efficacy in multiple preclinical tumor models," an overview of data on its lead pre-clinical candidate, VET3-TGI, in an oral presentation at the American Society of Gene & Cell Therapy (ASGCT) (Free ASGCT Whitepaper) Annual Meeting (Press release, KaliVir Immunotherapeutics, MAY 3, 2023, View Source;cell-therapy-asgct-annual-meeting-301813498.html [SID1234630951]). The presentation is on Friday, May 19, 2023 at 5:15 PM PST.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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VET3-TGI is based on KaliVir’s unique Vaccinia Enhanced Template (VET) platform, capable of generating potent novel oncolytic vaccinia viruses with modifications to maximize viral replication and to enhance intravenous delivery and spread. VET3-TGI incorporates modifications granting the expression of CXCR3, IL-12 and a TGF-β inhibitor, allowing for efficient trafficking to the tumor, activation of anti-tumor immune responses and inhibition of immunosuppressive activity.

On May 3, 2023 Lytix Biopharma – Lytix Biopharma AS ("Lytix") (Euronext Growth Oslo: LYTIX), a Norwegian immuno-oncology company – reported that Dr Øystein Rekdal, CEO in Lytix Biopharma, will give an oral presentation at the `Frontiers in Cancer Immunotherapy 2023′ conference, which is taking place in New York, USA (Press release, Lytix Biopharma, MAY 3, 2023, View Source [SID1234630950]).

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Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Dr Rekdal has been invited by the New York Academy of Sciences to discuss how tumor-directed strategies enable superior immune-stimulation of `cold’ non-infiltrated tumors, in a joint presentation with Lorenzo Galluzzi, PhD, Weill Cornell Medicine. In his presentation, Rekdal will put particular emphasis on the efficacy data achieved in human clinical trials performed with LTX-315 and how oncolytic molecules can address the challenge represented by the modest activity of immune checkpoint inhibitors (ICIs) in patients with immunologically `cold’ tumors. The presentation will be performed in Session 9: Cancer Vaccines, on May 3.

"Our technology platform delivers molecules with the potential to recruit immune cells into the tumor microenvironment in support of strong anticancer immunity, solving one of the major hurdles in cancer treatment. We are grateful for being invited by the New York Academy of Sciences (NYAS) to this conference and to present our clinical data confirming the strong pre-clinical evidence of our proposed solution to the problem of `cold’ tumors in cancer immunotherapy", says Dr. Øystein Rekdal.

Title: `Clinically Viable Tumor-Directed Strategies to Enable Superior Immunostimulation in Cold Neoplasms’

Date and time: Wednesday May 3, 2023, at 14.30-15.00 ET

About the Congress

Over the last 10 years, cancer immunotherapy has seen tremendous scientific development and clinical success. The field of immuno-oncology continues to advance at a rapid pace, with great potential to further revolutionize patient outcomes. The conference provides an opportunity to be part of the leading forum for scientists and clinicians to keep up with the latest trends and developments in the field. At the conference world-renowned leaders in the field like Nobel Laureate Dr. James Allison (University of Texas, MD Anderson Cancer Center), Dr. Nina Bhardwaj (Icahn School of Medicine, Mount Sinai), and Dr. Robert D. Schreiber (Washington University School of Medicine in St. Louis) will deliver keynote presentations. Speakers from leading biotech and life sciences companies including Enable Medicine, Gritstone Bio, Infinity Pharmaceuticals, and Lytix Biopharma will complement the presentations with evidence from industrial-academic collaborations.

On May 3, 2023 Convergent Therapeutics Inc., a clinical-stage biotechnology company focused on the development of next-generation radiopharmaceuticals for the treatment of cancer, reported the completion of a $90 million Series A financing, led by OrbiMed and RA Capital Management with participation from Invus (Press release, Convergent Therapeutics, MAY 3, 2023, View Source [SID1234630949]). The financing will support the development of a pipeline of novel radioantibodies, including its lead program with CONV01-α, for the treatment of advanced prostate cancer.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Dr. Philip Kantoff, Convergent CEO, and Dr. Neil Bander, Chief Scientific Advisor to Convergent, co-founded the company with technology developed in the Bander Lab and licensed from Cornell University. Dr. Bander is the Bernard & Josephine Chaus Professor of Urologic Oncology at Weill Cornell Medicine and is recognized worldwide for his contributions to prostate-specific membrane antigen (PSMA) biology and the related advancement of PSMA directed imaging and therapeutics. Dr. Bander and his colleagues were the first to validate PSMA as a target in cancer.

Dr. Kantoff is the former Chairman of the Department of Medicine at Memorial Sloan Kettering Cancer Center, former Chief of Solid Tumor Oncology at the Dana-Farber Cancer Institute and the Jerome and Nancy Kohlberg Chair Emeritus at Harvard Medical School. Dr. Kantoff contributed to the advancement of clinical biomarkers and multiple FDA-approved treatments for prostate cancer over his three decades of work as an academic oncologist.

"While considerable progress has been made in the search for effective treatments for prostate cancer, it continues to be the second leading cause of cancer death in men1, representing a significant unmet need," said Dr. Kantoff. "This financing is an important milestone for Convergent and accelerated development of novel radioantibodies, beginning with CONV01-α. We view this program as a best-in-class, targeted treatment for prostate cancer and will be advancing CONV01-α clinical development over the immediate term. With the founding of Convergent, our focus has been on the amalgamation of world-class expertise to identify and develop new radiopharmaceutical treatments for a wide range of cancers."

Tal Zaks, M.D., Ph.D., Partner at OrbiMed, said, "In our goal of improving healthcare for patients, we believe that Convergent Therapeutics’ radioantibody approach is ideally suited to treat cancer and bring effective breakthrough treatments to patients. We look forward to collaborating with the Convergent team, whose extensive expertise in prostate cancer, foundational leadership in radiopharmaceuticals and patient-focused mindset will be invaluable in taking the company forward."

Jake Simson, Ph.D., Partner at RA Capital Management, added, "We are proud to support Convergent and believe its radioantibody technology is an exciting approach to radiopharmaceuticals that will have significant implications for patients. As we witness encouraging progress in the radiopharmaceutical field with new emerging therapies to treat various types of cancer, we believe that Convergent is well-positioned."

In addition to initiating the next phase of clinical development for CONV01-α, Convergent Therapeutics is pursuing additional radioantibody targets to treat cancer. The company is currently evaluating other in-licensing and pipeline acquisition opportunities.

Citigroup acted as the sole placement agent for this transaction.

On May 3, 2023 Reprocell USA, a CRO, reported that it has been awarded a contract to provide support for Lantern Pharma’s Phase 2 clinical trial entitled "A Study of LP-300 With Carboplatin and Pemetrexed in Never Smokers with Advanced Lung Adenocarcinoma (HARMONIC)" (Press release, Lantern Pharma, MAY 3, 2023, View Source [SID1234630948]). The Harmonic study is being conducted to determine clinical advantages for Lantern Pharma’s investigational new drug LP-300 in combination with carboplatin and pemetrexed in patients who are never smokers with lung adenocarcinoma and have relapsed after treatment with tyrosine kinase inhibitors (TKIs).

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"We are excited to select Reprocell to support our Phase 2 Harmonic trial for never smokers with advanced non-small cell lung cancer," stated Reggie Ewesuedo, M.D., M.Sc., MBA, Lantern’s VP of Clinical Development. "Reprocell has an excellent and proven track record of processing and storing clinical trial samples and we are confident that this partnership will further the advancement of the Harmonic trial."

Reprocell will produce Specimen Collection Kits, process patient samples and store biomaterial from patients in this study. Additionally, Reprocell will provide isolation of cell free DNA from plasma, genomic DNA and/or RNA from the buffy coat fraction, and archive pathology FFPEs and associated H&E-stained slides from selected patients. These services are routine procedures utilized at Reprocell and will be performed at the conclusion of specimen collection and processing. Reprocell will retain all biomaterials and pathology materials on-site until required by Lantern Pharma later.

"We are pleased to support Lantern Pharma in the Harmonic clinical trial. We believe that our capabilities in building kits, managing shipments to and from clinical sites and processing the bio samples will help Lantern Pharma in successfully conducting this trial," said Rama Modali, CEO, REPROCELL USA.

About the Harmonic Trial

The Harmonic trial (NCT05456256) is a Phase 2 clinical trial that is assessing the effect of Lantern’s investigational new drug LP-300 in combination with standard-of-care (SOC) chemotherapy, pemetrexed and carboplatin, on the overall and progression-free survival of never smoker patients with advanced non-small cell lung cancer (NSCLC). The study has been designed as a 90 patient trial with approximately 2/3rds of the patients receiving LP-300 with chemotherapy and the remaining 1/3rd receiving chemotherapy alone. Lantern has activated 5 clinical trial sites, across 12 locations in the US including Gabrail Cancer Center, Northwest Oncology, New York Cancer and Blood Specialists, Texas Oncology, and Cancer and Blood Specialty Clinic. The first patient in the trial was recently dosed and there are multiple additional potential patients that have been pre-screened and are being monitored for possible enrollment.

In a previous multi-center Phase 3 clinical trial, a subset of never smoker NSCLC patients who received LP-300 with chemotherapy showed increased overall and two-year survival of 91% and 125%, respectively, compared to patients who only received chemotherapy. In addition, LP-300 has been administered in multiple clinical trials to more than 1,000 people and has been generally well tolerated. Additional information on the Harmonic trial can be found at the Harmonic clinical trial website, on ClinicalTrials.gov, or on the first-of-its-kind Harmonic trial iPhone app, which is focused on education & awareness for never smoker NSCLC patients and the NSCLC community.