Roche’s First Quarter Results 2023

On April 26, 2023 Hoffmann-La Roche reported its first quarter 2023 results (Presentation, Hoffmann-La Roche, APR 26, 2023, View Source [SID1234632846]).

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GSK momentum continues with strong start to 2023

On April 26, 2023 GlaxoSmithKline reported its first quarter 2023 results (Press release, GlaxoSmithKline, APR 26, 2023, View Source [SID1234632840]).

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20-F – Annual and transition report of foreign private issuers [Sections 13 or 15(d)]

CASI Pharmaceuticals has filed a 20-F – Annual and transition report of foreign private issuers [Sections 13 or 15(d)] with the U.S. Securities and Exchange Commission .

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Entry into a Material Definitive Agreement

On April 26, 2023 (the "Closing Date"), Eterna Therapeutics Inc., a Delaware corporation (the "Company"), reported to have entered into an asset purchase agreement (the "Purchase Agreement"), together with Exacis Biotherapeutics Inc. ("Exacis"), the stockholders party thereto (the "Stockholders") and, with respect to specified provisions therein, Factor Bioscience Limited ("Factor") (Filing, 8-K, Brooklyn ImmunoTherapeutics, APR 26, 2023, View Source [SID1234630829]). Pursuant to the Purchase Agreement, the Company acquired from Exacis substantially all of Exacis’ intellectual property assets (the "Purchased Assets"), including all of Exacis’ right, title and interest in and to an exclusive license agreement by and between Exacis and Factor (the "Purchased License"). The Company assumed none of Exacis’ liabilities, other than liabilities under the Purchased License that accrue subsequent to the Closing Date.

In consideration for the Purchased Assets, on the Closing Date, the Company issued to Exacis an aggregate of 69,343 shares of the Company’s common stock, par value $0.005 per share ("Common Stock"), which shares are subject to a 12-month lockup, pursuant to which Exacis may not sell or otherwise transfer such shares. The Company additionally agreed to make the following contingent payments: (i) if, at any time during the three-year period commencing on the Closing Date and ending on the three-year anniversary of the Closing Date, the Company’s market capitalization equals or exceeds $100.0 million for at least ten consecutive trading days, then the Company will issue to Exacis a number of shares of Common Stock equal to (x) $2.0 million divided by (y) the quotient of $100.00 million divided by the number of the Company’s then issued and outstanding shares of Common Stock; (ii) if, at any time during the three-year period commencing on the Closing Date and ending on the three-year anniversary of the Closing Date, the Company’s market capitalization equals or exceeds $200.0 million for at least ten consecutive trading days, then the Company will issue to Exacis a number of additional shares of Common Stock equal to (x) $2.0 million divided by (y) the quotient of $200.00 million divided by the number of the Company’s then issued and outstanding shares of Common Stock; and (iii) during the five-year period commencing on the Closing Date and ending on the five-year anniversary of the Closing Date (the "Five-Year Period"), the Company will pay or deliver to Exacis 20% of all cash or other consideration (collectively, "License Consideration") actually received by the Company during the Five-Year Period from (i) third-party licensees or sublicensees of the intellectual property rights acquired by the Company from Exacis pursuant to the Purchase Agreement, or (ii) subject to certain exceptions, the sale of such intellectual property rights; provided, that the License Consideration shall not in any event exceed $45.0 million.

The Purchase Agreement contains customary representations and warranties of the parties thereto, and Exacis and the Stockholders have agreed to five-year non-competition and non-solicitation covenants in favor of the Company.

In the Purchase Agreement, Exacis represented to the Company that it is an "accredited investor", as defined in Rule 501 promulgated under the Securities Act of 1933, as amended (the "Securities Act"), and the Company’s offer and sale of the shares of Common Stock described above have been made in reliance upon the exemptions from the registration requirements of the Securities Act pursuant to Section 4(a)(2) thereof and Rule 506(b) of Regulation D promulgated thereunder.

Dr. Matthew Angel, the Company’s President and Chief Executive Officer, is the co-founder, President, CEO, and a director of Factor Bioscience Inc., which is the parent of Factor and a wholly owned subsidiary of Factor Bioscience LLC, the latter of which is the majority stockholder of Exacis. Dr. Gregory Fiore, one of the Company’s directors, is the Chief Executive Officer and a 10% stockholder of Exacis. The Purchase Agreement and the transactions contemplated thereby were approved by the audit committee of the Company’s board of directors (the "Board"), as well as by all of the Company’s disinterested directors, comprising a majority of the Board.

The foregoing description of the Purchase Agreement is only a summary and is qualified in its entirety by reference to the full text of the Purchase Agreement, a copy of which is filed herewith as Exhibit 10.1 and incorporated herein by reference.

The Purchase Agreement is filed with this Current Report on Form 8-K to provide securityholders with information regarding its terms. It is not intended to provide any other factual information about the Company, Exacis or any other party thereto. The representations, warranties and covenants contained in the Purchase Agreement were made solely for purposes of such agreement and as of specific dates, are solely for the benefit of the parties to the Purchase Agreement, may be subject to limitations agreed upon by the contracting parties, including being qualified by confidential disclosures made for the purpose of allocating contractual risk between the parties to the Purchase Agreement instead of establishing these matters as facts, and may be subject to standards of materiality applicable to the contracting parties that differ from those applicable to securityholders. Securityholders should not rely on the representations, warranties and covenants or any descriptions thereof as characterizations of the actual state of facts or condition of the Company, Exacis or any other party thereto. Moreover, information concerning the subject matter of the representations and warranties may change after the date of the Purchase Agreement, which subsequent information may or may not be fully reflected in the Company’s public disclosures, except to the extent required by law.

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IN8bio Announces Oral Presentation of New INB-200 Phase 1 Data in Glioblastoma (GBM) to be Presented at 2023 ASCO Annual Meeting

On April 26, 2023 IN8bio, Inc. (Nasdaq: INAB), a leading clinical-stage biopharmaceutical company focused on innovative gamma-delta T cell therapies, reported an oral presentation at the upcoming 2023 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting, taking place in Chicago from June 2-6, 2023 (Press release, In8bio, APR 26, 2023, View Source [SID1234630670]). The oral presentation will highlight new Phase 1 study results evaluating the safety, tolerability and efficacy of INB-200, a potentially promising treatment for newly diagnosed glioblastoma multiforme (GBM).

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"We are excited that the Phase I trial of INB-200 in GBM has been selected for an oral presentation at ASCO (Free ASCO Whitepaper)," said William Ho, CEO and co-founder of IN8bio. "GBM is a highly aggressive and difficult-to-treat brain cancer, where treatment options have remained largely unchanged for almost two decades. The current median progression-free survival with the standard of care for GBM is 6-7 months and overall survival is only 14-16 months. We believe that our unique approach to solid tumor cancers targeting the DNA damage response with our genetically engineered gamma-delta T cells may eliminate more cancer cells and potentially prolong the time to relapse or death."

Details of the oral presentation are as follows:

Abstract Title: INB-200 Phase I Study of Gene Modified Autologous Gamma-Delta (γδ) T Cells in Patients with Newly Diagnosed Glioblastoma Multiforme (GBM) Receiving Maintenance Temozolomide (TMZ)
Abstract #: 2007
Session: S100a – Central Nervous System Tumors
Date and Time: Friday, June 2, 2023, 2:45 PM CDT (3:45 PM EDT)

The abstract will be available on Thursday, May 25 at 5:00 PM EDT on ASCO (Free ASCO Whitepaper).org.

About INB-200

INB-200 is a genetically modified autologous drug resistant immunotherapy (DRI) product candidate for the treatment of solid tumors. This novel platform utilizes genetic engineering to generate chemotherapy resistant gamma delta T cells which can be administered concurrently with standard-of-care treatment in solid tumors. This is a powerful, synergistic treatment approach enabling gamma-delta T cells to persist in the presence of chemotherapy, and maintain their natural ability to recognize, engage and kill cancer cells.

INB-200 is the first genetically engineered gamma-delta T cell therapy to be administered to patients with solid tumors and our initial indication is in GBM.