AbbVie to Host First-Quarter 2023 Earnings Conference Call

On April 4, 2023 AbbVie (NYSE: ABBV) reported that it will announce its first-quarter 2023 financial results on Thursday, April 27, 2023, before the market opens (Press release, AbbVie, APR 4, 2023, View Source [SID1234629785]). AbbVie will host a live webcast of the earnings conference call at 8 a.m. CT. It will be accessible through AbbVie’s Investor Relations website investors.abbvie.com. An archived edition of the session will be available later that day.

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Alphamab Oncology Reports Full Year 2022 Financial Results and Business Highlights

On April 3, 2023 Alphamab Oncology (stock code: 9966.HK) reported financial results for the full year ended December 31, 2022 and highlighted recent progress and upcoming milestones (Press release, Alphamab, APR 3, 2023, View Source [SID1234632918]).

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Gossamer Bio Inc. announces FDA has placed a partial clinical hold on all trials of GB5121 in response to serious adverse events

On April 3, 2023 Gossamer Bio, Inc. (the "Company") reported that the U.S. Food and Drug Administration (the "FDA") has placed a partial clinical hold on all trials of GB5121, in response to serious adverse events that have been observed in the Phase 1b/2 STAR-CNS study, including atrial fibrillation, a sudden death event and a fatal intracranial hemorrhage (Press release, Gossamer Bio, APR 3, 2023, View Source [SID1234631618]). The Company previously announced on March 17, 2023 that it had paused enrollment of the Phase 1b/2 STAR-CNS Study based on the benefit / risk profile observed to date and a prioritization of resources to support the Company’s seralutinib program. Based on the foregoing factors, the Company has decided to terminate all ongoing studies and discontinue development of GB5121.

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Oxcia has been awarded a grant of 3 million SEK for a study in refractory AML patients

On April 3, 2023 Oxcia AB reported that it has been awarded a grant of 3 million SEK (Press release, Oxcia, APR 3, 2023, View Source [SID1234629860]). The call aims to finance the development of innovative and sustainable life science solutions that contribute to strengthening Swedish competitiveness and increase patient benefit. The financed projects must have great potential to make care more efficient and contribute to sustainable growth.

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Oxcia is currently investigating OXC-101 in a phase 1 study in AML, MAATEO. It is an oral drug. Preliminary data is promising in a very fragile and advanced patient population. In this call project, Oxcia collaborates closely with Karolinska Institute, Karolinska University Hospital and Örebro University Hospital to demonstrate efficacy as well as further proof of safety in monotherapy as well as in combination with chemotherapy in refractory/relapsed AML. This expansion cohort to MAATEO is a critical step to be able to take the project further in development. Early data indicate that OXC-101 has potential to improve treatment for a broad patient population. In the project we are also integrating precision medicine screening to help identify best responders/non-responders. Precision medicine screening is a novel way of personalizing treatment for patients and thus identifying the best treatment strategy for individuals reducing unsuccessful treatments with unnecessary suffering and lack of effect.

OXC-101 is a mitotic MTH1 inhibitor combining a new and innovative method of attacking how cancer cells defend themselves against oxidative DNA damage with a proven method of stopping the cancer cell from multiplying, which leads to an entirely unique mechanism of action. It does so through inhibiting microtubule function, a protein complex vital to cell division, and MTH1, an enzyme crucial to preventing oxidative DNA damage. As a consequence, the cancer cell stops dividing, more oxidative stress and damaged DNA building blocks are generated and incorporated into DNA. The level of oxidative stress and DNA damage gets very high and with the repair MTH1 enzyme inhibited, the cancer cell is pushed up over the threshold level where it is unable to repair itself and the cancer cell dies. In short, OXC-101, fights cancer by taking advantage of one of the Achilles heels of cancer cells – the high endogenous oxidative stress and DNA damage. Apart from the mentioned phase 1 in hematological cancers, OXC-101 is investigated in a clinical phase 1 trial in solid cancers, in which recommended phase 2 dose (RP2D) has been reached and phase II is in the planning phase.

AML (Acute myeloid leukemia) is the most common acute leukemia in adults, accounting for more than 80% of the cases. In 2021, there were 162,200 incident cases of AML worldwide, and the number is forecasted to increase to 169,000 incident cases by 2027 (Datamonitor). AML is an aggressive hematological malignancy, with an overall 5-year survival of 20% in selected population. AML is a very heterogenous disease, which explains that classical intensive chemotherapy remains the standard of care (SoC).

"We really believe OXC-101 holds potential to greatly improve treatment for patients who suffer from AML and are very glad that Swelife and Medtech4Health have awarded us this grant. It enables us to progress development in a subpopulation with a large medical need and is a stepping stone for further studies says Ulrika Warpman Berglund, Oxcia’s CEO.

Palisade Bio Announces $6 Million Registered Direct Offering and Concurrent Private Placement Priced Above Market Under Nasdaq Rules

On April 3, 2023 Palisade Bio, Inc. (Nasdaq: PALI), a biopharmaceutical company advancing therapies for acute and chronic gastrointestinal (GI) complications, reported that it has entered into definitive agreements with institutional investors for the purchase of 2,272,723 shares of common stock (or certain pre-funded warrants in lieu thereof) in a registered direct offering and concurrent private placement, at a purchase price per share of $2.64 (Press release, Palisade Bio, APR 3, 2023, View Source [SID1234629839]). Certain investors will receive a portion of their investment in unregistered shares or unregistered pre-funded warrants in the private placement in lieu of registered common stock.

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Ladenburg Thalmann & Co. Inc. is acting as the exclusive placement agent for the registered direct and private placement offerings.

Palisade Bio intends to use the net proceeds from the financing for working capital and general corporate purposes.

The company has also agreed to issue to the investors, in a private placement, unregistered warrants to purchase up to 2,272,723 shares of common stock (the "Common Warrants"). These Common Warrants will have a term of five (5) years and an exercise price of $2.64 per share. Accordingly, the company entered into agreements to sell (i) an aggregate of 756,317 shares of registered common stock, (ii) an aggregate of 1,516,406 shares of unregistered common stock and unregistered pre-funded warrants to purchase common stock, and (iii) 2,272,723 unregistered Common Warrants. The closing of the offering is expected to take place on or about April 5, 2023, subject to the satisfaction of customary closing conditions.

The shares of common stock (but not the unregistered shares of common stock and unregistered pre-funded warrants, nor the Common Warrants or shares of common stock underlying such unregistered pre-funded warrants and Common Warrants) offered in the registered direct offering are being offered and sold by the Company pursuant to a "shelf" registration statement on Form S-3 (Registration No. 333-263705), including a base prospectus, previously filed with and declared effective by the Securities and Exchange Commission ("SEC") on April 26, 2022. The offering of the shares of common stock in the registered direct transaction are being made only by means of a prospectus supplement that forms a part of the registration statement. A final prospectus supplement and an accompanying base prospectus relating to the registered direct offering will be filed with the SEC and will be available on the SEC’s website located at View Source Electronic copies of the prospectus supplement and accompanying base prospectus may also be obtained, when available, by contacting Ladenburg Thalmann & Co. Inc. at Attn: Prospectus Department, 640 Fifth Avenue, 4th Floor, New York, NY 10019 or by e-mail at [email protected].

The unregistered shares of common stock, unregistered pre-funded warrants, the Common Warrants (and the shares of common stock underlying such unregistered pre-funded warrants and Common Warrants) are being offered in a private placement under Section 4(a)(2) of the Securities Act of 1933, as amended (the "Act") and/or Regulation D promulgated thereunder, and such securities have not been registered under the Act or applicable state securities laws. Accordingly, such securities may not be offered or sold in the United States except pursuant to an effective registration statement or an applicable exemption from the registration requirements of the Act and such applicable state securities laws. Palisade Bio has agreed to file a registration statement with the SEC registering the resale of the unregistered shares of common stock and shares of common stock issuable upon the exercise of the unregistered pre-funded warrants and Common Warrants.