On April 4, 2023 Bicara Therapeutics, a clinical-stage biotechnology company developing dual-action biologics to elicit a potent and durable immune response, reported that it will present preclinical data supporting the ongoing clinical development of the lead investigational candidate BCA101, a bifunctional antibody designed to sequester the immunosuppressive TGF-β in the tumor microenvironment (TME) of EGFR+ tumors, at the upcoming American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting 2023, being held April 14-19, 2023 in Orlando, Florida (Press release, Bicara Therapeutics, APR 4, 2023, View Source;utm_medium=rss&utm_campaign=bicara-therapeutics-to-present-preclinical-data-from-clinical-stage-bifunctional-antibody-program-bca101-at-aacr-annual-meeting-2023 [SID1234629787]).
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"The preclinical data that will be presented at AACR (Free AACR Whitepaper) supports the mechanism of action (MOA) of BCA101, which has demonstrated promising efficacy and a positive safety profile in an ongoing Phase 1/1b clinical trial. Data from in vitro and in vivo studies provides further evidence of BCA101’s potential, as a monotherapy and in combination with anti-PD-1, to induce durable anti-tumor responses in various tumor types, including head and neck cancer, our lead indication," said Rachel Salazar, SVP of R&D Strategy and Operations of Bicara Therapeutics. "We are also pleased to highlight our collaboration with researchers at the Belfer Center for Applied Cancer Science at Dana-Farber Cancer Institute to elucidate the effects of BCA101 on the tumor microenvironment of patients enrolled in the ongoing Ph1/1b clinical trial and highlight the important role of TGF-b neutralization in creating the conditions for an enhanced immune response."
Details of the presentations are as follows:
Title: BCA101, a novel tumor-targeted bifunctional fusion antibody simultaneously inhibiting EGFR and TGF-β signaling with potential for durable tumor growth inhibition
Presenter: Pradip Nair, Associate Research Director, Syngene International
Presentation Type: Poster
Session Category: Anticancer Immunotherapeutics
Date/Time: Wednesday, April 19, 2023, 9:00 a.m. to 12:30 p.m. ET
Location: Section 22; Abstract #6339
Title: Preliminary immune correlatives from BCA101 trial show favorable modulation of tumor immune microenvironment
Presenter: Patrick H. Lizotte, Lead Scientist, Dana-Farber Cancer Institute, Belfer Center for Applied Cancer Science
Presentation Type: Poster
Session Category: Immune Monitoring and Responses to Therapy
Date/Time: Wednesday, April 19, 2023, 9:00 a.m. to 12:30 p.m. ET
Location: Section 39; Abstract #6677
Title: An improved trispecific antibody (TsAb) platform for optimally engaging T cells for the treatment of solid tumor malignancies
Presenter: Avanish K. Varshney, Director of Antibody Discovery and Engineering, Bicara Therapeutics
Presentation Type: Poster
Session Category: Therapeutic Antibodies 1
Date/Time: Monday, April 17, 2023, 9:00 a.m. to 12:30 p.m. ET
Location: Section 25; Abstract #1864
All presentations described here will be made available on the Bicara website following the conference.