On March 1, 2023 a biotechnology company leveraging its next-generation chemoproteomics platform to discover medicines for challenging-to-drug targets, reported that management will participate in the following upcoming investor conferences (Press release, Jnana Therapeutics, MAR 1, 2023, View Source [SID1234628024]).

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Cowen 43rd Annual Health Care Conference, March 6-8, 2023. Boston Management will participate in one-on-one meetings.
Oppenheimer 33rd Annual Healthcare Conference, March 13-15, 2023 (Virtual). Joanne Kotz, Ph.D., Co-Founder and CEO, will present a company overview at 2:00 p.m. ET on March 15. Management will also participate in one-on-one meetings.

On March 1, 2023 Tachyon Therapeutics, Inc. ("Tachyon" or "the Company"), a private, clinical-stage biotechnology company developing transformative cancer therapies against novel targets reported the closing of a financing that brings the Company’s total equity financing raises to $11.6 million and, together with a recently reported CIRM grant of $7.1 million, brings total funding in the Company to $18.7 million since the Company started operations in 2020 (Press release, Tachyon Therapeutics, MAR 1, 2023, View Source [SID1234628023]). The round includes new investors, Veblen Ventures, Khosla Ventures, and Red Tree Venture Capital, and existing investors, demonstrating their continued commitment to supporting Tachyon’s potential. Proceeds from the financing are being used to run the Phase 1 clinical study in advanced solid tumors for TACH101, a first-in-class, small molecule, KDM4 histone demethylase inhibitor, as well as to advance the Company’s pipeline of emerging oncology drug candidates targeting previously unexplored mechanisms of tumorigenesis.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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"The Tachyon team are enabling new frontiers in targeted oncology by developing cancer therapies that address fundamental drivers of tumorigenesis," commented Heath Lukatch, Ph.D., Managing Director of Red Tree Venture Capital. "We look forward to supporting the team as they work towards transforming the treatment paradigms for advanced and metastatic solid tumors."

"This new capital, from a committed and distinguished investor syndicate that includes new and existing investors as well as the grant from CIRM, highlights the progress we’ve made to bring our lead program into the clinic," said Frank Perabo, M.D. Ph.D., Chief Executive Officer of Tachyon.

Founded on the scientific work of Drs. Stephen Quake and Michael Clarke at Stanford University, Tachyon Therapeutics is developing novel, first-in-class therapeutics that target pathways to fight cancer at its core tumorigenic mechanisms. In November 2019, Tachyon received an exclusive license to research, develop, and commercialize products for small molecule inhibitors of KDM4 including TACH101 (formerly QC8222) from Celgene Quanticel Research, Inc, now Bristol Myers Squibb, Summit, NJ. The Company recently received clearance of the Company’s Investigational New Drug (IND) application for TACH101 and enrolled its first patient in a Phase 1 clinical study in patients with advanced or metastatic solid tumors (ClinicalTrials.gov Identifier NCT05076552).

"The start of our first clinical trial for TACH101, our lead program, is a significant milestone for the company as we strive to bring promising new therapeutics to patients who are fighting advanced cancers," continued Dr. Perabo. "We are also pleased to welcome to our Board of Directors, Dr. Jeff Stafford, who has decades of experience in developing innovative small molecule therapeutics against novel cancer targets and led the initial discovery and development of our novel KDM4-inhibitor, TACH101."

Dr. Stafford is the President and CEO of 858 Therapeutics. Prior to this, he was the founding CSO of Quanticel Pharmaceuticals (acquired by Celgene), where his team discovered TACH101 from a single cell genomics platform for precision targeting of cancer stem cells. Dr. Stafford has also held senior scientific and management positions at Takeda and GlaxoSmithKline and was the founding CEO of Jecure. Dr. Stafford’s discovery teams have been responsible for the discovery of three FDA-approved drugs – Votrient (pazopanib), Nesina (alogliptin), and Byfavo (remimazolam) – and several others currently in clinical trials.

On March 1, 2023 Celanese Corporation (NYSE: CE), a global specialty materials and chemical company, and Alessa Therapeutics reported their collaboration for developing a new oncology drug product leveraging Alessa’s expertise on sustained localized drug delivery and the Celanese VitalDose EVA drug delivery platform (Press release, Celanese, MAR 1, 2023, View Source [SID1234628022]). The collaboration will focus on developing a localized and sustained-release drug delivery system for oncology patients that will limit systemic side effects and improve overall treatment.

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"The commercial flexibility, responsiveness and technical support provided by Celanese has enabled the rapid progression of our drug candidate," says Maithili Rairkar, Vice President of Technical Operations at Alessa Therapeutics. "We look forward to progressing this innovative local drug delivery approach beginning with human studies later this year."

"Our new collaboration with Alessa Therapeutics underscores our commitment to optimize therapeutics through drug delivery innovation for oncology patients," said Karen Chen, Global Business Strategy Leader for Oncology at Celanese. "Delivery can be a fundamental, and oftentimes overlooked, part of a drug’s success, and we believe that our contribution to Alessa’s work can make a meaningful difference in the lives of cancer patients."

On March 1, 2023 RenovoRx, Inc. ("RenovoRx" or the "Company") (Nasdaq: RNXT), a biopharmaceutical company focused on the localized treatment of solid tumors, reported that Shaun Bagai, Chief Executive Officer, will be presenting at the 35th Annual Roth Conference, to be held March 12-14, 2023, in Dana Point, California (Press release, Renovorx, MAR 1, 2023, View Source [SID1234628021]). To register for the event, visit the conference website.

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During the presentation, Mr. Bagai will discuss the company’s mission to become a leading provider in oncology therapy by disrupting the standard of care (intravenous systemic chemotherapy) treatment of difficult-to-treat cancers. Mr. Bagai will review how its lead product candidate, RenovoGem , which utilizes RenovoRx’s proprietary therapy platform, RenovoTAMP, may provide a potential targeted intra-arterial treatment option to solid tumors. The goals of the Company’s therapy platform are to improve quality of life for patients diagnosed with cancer by reducing the debilitating side effects typical of the standard of care treatment and to extend patient survival. Additionally, Mr. Bagai will give an update on the Company’s pivotal Phase III TIGeR-PaC clinical trial which has its first interim analysis targeted for reporting early this year.

Conference Details
Event Name: 35th Annual Roth Conference
Date: March 13, 2023
Presentation: 2:00 PM Pacific Time (11:00 AM Eastern Time)
Location: Dana Point, CA

RenovoRx leadership will be available during the conference for one-on-one meetings with the investment community. To schedule a meeting please reach out to your Roth representative or by emailing KCSA Strategic Communications: [email protected].

The live audio webcast and replay will be available in the investor relations section of the Company’s website.

On March 1, 2023 Novocure (NASDAQ: NVCR) reported that the final patient has enrolled in the pivotal METIS study evaluating the efficacy of Tumor Treating Fields (TTFields) therapy following stereotactic radiosurgery (SRS) for treatment of patients with brain metastases resulting from non-small cell lung cancer (NSCLC) (Press release, NovoCure, MAR 1, 2023, View Source [SID1234628020]).

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"We are pleased to announce the completion of enrollment in the METIS study, our fourth pivotal study to complete enrollment in the last 17 months and our second study addressing non-small cell lung cancer," said William Doyle, Novocure’s Executive Chairman. "Beginning with the top-line readout from the LUNAR study earlier this year, we expect a steady cadence of meaningful pivotal datasets through 2024. This is a transformational period for Novocure and, potentially, for the treatment of solid tumor cancers."

Following the completion of enrollment, patients will be followed for a minimum of 12 months.

METIS is a randomized, open-label pivotal study which was designed to enroll 270 adult patients with between 1 and 10 brain metastases resulting from NSCLC. Following SRS, patients were randomized to receive either TTFields therapy and supportive treatment or supportive treatment alone. The primary endpoint is time to first intracranial progression. Secondary endpoints include, but are not limited to, time to neurocognitive failure, overall survival, radiological response rate, time to second intracranial progression, quality of life and adverse events.

About Brain Metastases

Metastatic cancer is cancer that has spread from the place where it first started to another place in the body. In metastasis, cancer cells break away from where they first formed (the primary cancer), travel through the blood or lymph system, and form new tumors (the metastatic tumors) in other parts of the body. The exact incidence of brain metastases is unknown because no national cancer registry documents brain metastases, and estimates from scientific literature vary greatly based on the study methodology applied. It is estimated that between 100,000 and 240,000 new cases are diagnosed in the U.S. each year with brain metastases estimated to occur in between 10% to 40% of all cancer patients.

Brain metastases are commonly treated with a combination of surgery and radiation. Chemotherapy is often given for the primary tumor, but many chemotherapy agents do not cross the blood brain barrier and are thus ineffective in the treatment of brain metastases. When brain metastases appear, they are either surgically removed or treated with radiation using SRS when possible. Whole brain radiation therapy, although effective in delaying progression or recurrence of brain metastases when given either before or after SRS, is associated with neurotoxicity and a significant decline in cognitive functioning. Thus, whole brain radiation therapy is often delayed until later in the disease course and is often used as a last resort. This practice results in a window of unmet need after localized surgery and SRS are used and before whole brain radiation therapy is administered to delay or prevent the additional spread of brain metastases.

About Tumor Treating Fields Therapy

Tumor Treating Fields (TTFields) are electric fields that exert physical forces to kill cancer cells via a variety of mechanisms. TTFields do not significantly affect healthy cells because they have different properties (including division rate, morphology, and electrical properties) than cancer cells. The multiple, distinct mechanisms of TTFields therapy work together to selectively target and kill cancer cells. Due to its multimechanistic actions, TTFields therapy can be added to cancer treatment modalities in approved indications and demonstrates enhanced effects across solid tumor types when used with chemotherapy, radiotherapy, immune checkpoint inhibition, or PARP inhibition in preclinical models. TTFields therapy provides clinical versatility that has the potential to help address treatment challenges across a range of solid tumors. To learn more about Tumor Treating Fields therapy and its multifaceted effect on cancer cells, visit tumortreatingfields.com.