Lucid Diagnostics to Hold a Business Update Conference Call and Webcast on March 14, 2023

On March 3, 2023 Lucid Diagnostics Inc. (Nasdaq: LUCD) ("Lucid" or the "Company") a commercial-stage, cancer prevention medical diagnostics company and majority-owned subsidiary of PAVmed Inc. (Nasdaq: PAVM, PAVMZ), reported that it will host a business update conference call and webcast on Tuesday, March 14, 2023, at 8:30 AM EST (Press release, Lucid Diagnostics, MAR 3, 2023, View Source [SID1234628134]). During the call, Lishan Aklog, M.D., Lucid’s Chairman and Chief Executive Officer, will provide a business update, including an overview of the Company’s operations and growth strategy. In addition, Dennis McGrath, Lucid’s Chief Financial Officer, will discuss the Company’s fourth-quarter 2022 financial results.

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The webcast will be available at the investor relations section of the Company’s website at luciddx.com. Alternatively, to access the conference call by telephone, U.S.-based callers should dial 877-550-1858 and international listeners should dial 1-848-488-9160. All listeners should provide the operator with the conference call name "Lucid Diagnostics Business Update Conference Call" to join.

Following the conclusion of the conference call, a replay will be available for 30 days on the investor relations section of the Company’s website at luciddx.com.

PAVmed to Hold a Business Update Conference Call and Webcast on March 15, 2023

On March 3, 2023 PAVmed Inc. (Nasdaq: PAVM, PAVMZ) ("PAVmed" or the "Company"), a diversified commercial-stage medical technology company, operating in the medical device, diagnostics, and digital health sectors, reported that it will host a business update conference call and webcast on Wednesday, March 15, 2023, at 8:30 AM EST (Press release, PAVmed, MAR 3, 2023, View Source [SID1234628133]). During the call, Lishan Aklog, M.D., PAVmed’s Chairman and Chief Executive Officer, will provide a business update including an overview of the Company’s operations and growth strategy. In addition, Dennis McGrath, PAVmed’s President and Chief Financial Officer, will discuss the Company’s fourth-quarter 2022 financial results.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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The webcast will be available at the investor relations section of the Company’s website at pavmed.com. Alternatively, to access the conference call by telephone, U.S.-based callers should dial 877-550-1858 and international listeners should dial 1-848-488-9160. All listeners should provide the operator with the conference call name "PAVmed, Inc. Business Update Conference Call" to join.

Following the conclusion of the conference call, a replay will be available for 30 days on the investor relations section of the Company’s website at pavmed.com.

Aptorum Group Announces Completion of End of Phase 1 (EOP1) Meeting with US FDA on its SACT-1, a Repurposed Small Molecule Drug Targeting Neuroblastoma

On March 3, 2023 Aptorum Group Limited (Nasdaq: APM, Euronext Paris: APM) ("Aptorum Group" or "Aptorum"), a clinical-stage biopharmaceutical company, reported the completion of an end of Phase 1 (EOP1) meeting with the US Food and Drug Administration ("US FDA") (Press release, Aptorum, MAR 3, 2023, View Source [SID1234628132]). SACT-1 is a repurposed small molecule drug formulated in oral suspension targeting neuroblastoma in pediatric patients and has also received orphan drug designation previously from the US FDA.

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The EOP1 meeting was focused on gaining alignment with the US FDA regarding the clinical and regulatory pathway for SACT-1 for the treatment of neuroblastoma in pediatric patients aged 2-18. The FDA generally agreed with the chemistry-manufacturing-control (CMC) strategy and our proposed clinical development plan for Phase 1/2 trials.

Dr. Clark Cheng, Chief Medical Officer and Executive Director of Aptorum Group, commented: "We are pleased to announce the completion of End of Phase 1 Meeting with US FDA and this represents another key milestone for the company and one of the targeted strategic goals for the year of 2023. With additional supportive information from US FDA on the clinical development of SACT-1, this supports the continued focus of Aptorum Group to embark on the exciting Phase 1/2 clinical trials for SACT-1, subject to further FDA’s clearance of the final clinical protocol."

About SACT-1

SACT-1 is an oral suspension based repurposed small molecule drug formulated in oral suspension to target neuroblastoma. SACT-1’s mechanism has been investigated in our preclinical studies to enhance tumor cell death and suppress MYCN expression (a common clinical diagnosis in high-risk or relapsed neuroblastoma patients where an amplification of MYCN is usually observed). SACT-1 is designed to be used especially in combination with standard-of-care chemotherapy. SACT-1 has been observed to be potentially applicable to neuroblastoma and other cancers in the preclinical studies.

CEL-SCI to Present New Phase 3 Data at European Congress on Head & Neck Oncology

On March 3, 2023 CEL-SCI Corporation (NYSE American: CVM) reported it will present new data from its pivotal Phase 3 study, the largest study ever conducted in newly diagnosed locally advanced squamous cell carcinoma of the head and neck (SCCHN), on March 8, 2023 at the 10th European Congress on Head & Neck Oncology in Lisbon, Portugal (Press release, Cel-Sci, MAR 3, 2023, View Source [SID1234628131]). CEL-SCI will publish a summary of the findings shortly after the presentation.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Immune-Onc Therapeutics to Showcase Leadership in Myeloid Biology and Drug Development at Upcoming Scientific and Investor Conferences

On March 3, 2023 Immune-Onc Therapeutics, Inc. ("Immune-Onc"), a private, clinical-stage cancer immunotherapy company developing novel biotherapeutics targeting myeloid checkpoints, announced today its plans to present on the company’s myeloid biology research and clinical stage programs at three upcoming scientific and investor conferences in March. The presentations will highlight the potential of Immune-Onc’s pipeline of first-in-class myeloid checkpoint inhibitors to transform current treatment approaches for blood cancers and solid tumors.

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Keystone Symposia: Cancer Immunotherapy: Mechanisms of Response Versus Resistance
Date: Sunday, March 5 – Thursday, March 9
Location: Alberta, Canada

At the prestigious Keystone Symposia on Cancer Immunotherapy, Immune-Onc’s Scientific Founder Dr. Chengcheng Alec Zhang will join the company’s Chair of the Scientific Advisory Board (SAB), Dr. Michael Karin and Senior Director of Translational Research, Dr. Xiao Min Schebye for a series of pivotal presentations highlighting foundational research and insights driving our evolving understanding of mechanisms of response and resistance to cancer immunotherapy, and in particular, the LILRB family of immune inhibitory receptors as a promising class of therapeutic targets.

Oral Presentation Details:

Date: Monday, March 6
Presenter: Dr. Michael Karin, Immune-Onc SAB chair and professor of pharmacology at University of California, San Diego
Title: Inflammation and Cancer: A Double-Edged Sword
Oral Session: Dysfunctional Immune Cells in the TME
Date: Wednesday, March 8
Presenter: Dr. Xiao Min Schebye, senior director of translational research at Immune-Onc
Title: Anti-LAIR1 Antagonistic Antibodies Block Collagen-mediated Suppression of T Cell Activation
Oral Session: Workshop 2
Date: Wednesday, March 8
Presenter: Dr. Chengcheng Alec Zhang, scientific founder of Immune-Onc and the Morton H. Sanger Professorship in Oncology and Michael L. Rosenberg Scholar for Biomedical Research at University of Texas Southwestern Medical Center
Title: LILRBs – Myeloid Checkpoint Targets for Cancer Treatment
Oral Session: Innate Immune Pathways and the Anti-Tumor Response
2nd Year Anniversary Symposium of the Myeloid Network
Date: Thursday, March 9 from 11:00 a.m. – 2:30 p.m. ET
Title: Novel Myeloid Checkpoint Inhibitors as Next Generation Cancer Immunotherapy
Location: Virtual

Charlene Liao, Ph.D., founder, chief executive officer and board chair of Immune-Onc will present an overview of the company’s work advancing the field of myeloid checkpoint inhibitors at the 2nd Year Anniversary Symposium of the Myeloid Network. The Myeloid Network seeks to connect researchers worldwide to promote communication and advancement of research and medicine in the field of myeloid cell biology. "I think your work represents the biotechnology industry outstandingly and I would love to feature your work as the final talk of our annual symposium," said Judith Varner, Ph.D., co-founder of the Myeloid Network, professor of pathology and medicine and co-leader in solid tumor therapeutics at UC San Diego’s Moores Cancer Center in the invitation extended to Dr. Liao.

Oppenheimer 33rd Annual Healthcare Conference
Date: Monday, March 13 – Wednesday, March 15
Presentation: Tuesday, March 14 (4:00-4:30 p.m. ET)

Dr. Liao will present a corporate overview on Tuesday, March 14 at 4:00 – 4:30 p.m. ET (Track 2) and will participate in virtual one-on-one meetings.