QUEST DIAGNOSTICS REPORTS FOURTH QUARTER AND FULL YEAR 2022 FINANCIAL RESULTS; PROVIDES GUIDANCE FOR FULL YEAR 2023

On February 2, 2023 Quest Diagnostics Incorporated (NYSE: DGX), the world’s leading provider of diagnostic information services, reported financial results for the fourth quarter and full year ended December 31, 2022 (Press release, Quest Diagnostics, FEB 2, 2023, View Source [SID1234626776]).

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"Quest had another strong year in 2022, with base business revenues growing more than 6% in the fourth quarter, and 5% for the full year," said Jim Davis, CEO and President. "COVID-19 testing revenues declined as expected but still exceeded $1.4 billion in 2022.

"In 2023, our focus is on growing our base business and increasing our efforts to drive productivity and expand margins. Our guidance for the full year reflects continued growth in the base business, tailwinds from recent Medicare reimbursement changes, investments to accelerate growth, and declining COVID-19 revenues."

Three Months Ended December 31,

Twelve Months Ended December 31,

2022

2021

Change

2022

2021

Change

(dollars in millions, except per share data)

Reported:

Net revenues

$ 2,333

$ 2,744

(15.0) %

$ 9,883

$ 10,788

(8.4) %

Base business revenues (a)

$ 2,149

$ 2,022

6.3 %

$ 8,429

$ 8,018

5.1 %

COVID-19 testing revenues

$ 184

$ 722

(74.6) %

$ 1,454

$ 2,770

(47.5) %

Diagnostic information services revenues

$ 2,265

$ 2,674

(15.3) %

$ 9,609

$ 10,494

(8.4) %

Revenue per requisition

(5.1) %

(4.5) %

Requisition volume

(11.2) %

(4.5) %

Organic requisition volume

(11.4) %

(5.1) %

Operating income (b)

$ 135

$ 536

(74.9) %

$ 1,428

$ 2,381

(40.0) %

Operating income as a percentage of net revenues (b)

5.8 %

19.5 %

(13.7) %

14.5 %

22.1 %

(7.6) %

Net income attributable to Quest Diagnostics (b)

$ 101

$ 390

(74.2) %

$ 946

$ 1,995

(52.6) %

Diluted EPS (b) (c)

$ 0.87

$ 3.12

(72.1) %

$ 7.97

$ 15.55

(48.7) %

Cash provided by operations

$ 334

$ 481

(30.5) %

$ 1,718

$ 2,233

(23.1) %

Capital expenditures

$ 147

$ 144

2.7 %

$ 404

$ 403

0.3 %

Adjusted (b):

Operating income

$ 330

$ 579

(42.7) %

$ 1,742

$ 2,565

(32.0) %

Operating income as a percentage of net revenues

14.2 %

21.1 %

(6.9) %

17.6 %

23.8 %

(6.2) %

Net income attributable to Quest Diagnostics

$ 229

$ 416

(44.9) %

$ 1,181

$ 1,827

(35.4) %

Diluted EPS (c)

$ 1.98

$ 3.33

(40.5) %

$ 9.95

$ 14.24

(30.1) %

(a)

Excludes COVID-19 testing.

(b)

For further details impacting the year-over-year comparisons related to operating income, operating income as a percentage of net revenues, net income attributable to Quest Diagnostics, and diluted EPS, see note 2 of the financial tables attached below.

(c)

The sum of reported and adjusted diluted EPS for the four quarters of both 2022 and 2021 did not equal the totals for the years ended December 31, 2022 and 2021, respectively, due to both quarterly fluctuations in our earnings and in the weighted average common shares outstanding throughout the years.

Guidance for Full Year 2023

We estimate full year 2023 guidance as follows:

Low

High

Net revenues

$8.83 billion

$9.03 billion

Net revenues decrease

(10.7) %

(8.6) %

Base business revenues (a)

$8.65 billion

$8.75 billion

Base business revenues increase

2.6 %

3.8 %

COVID-19 testing revenues

$175 million

$275 million

COVID-19 testing revenues decrease

(88.0) %

(81.1) %

Reported diluted EPS

$7.61

$8.21

Adjusted diluted EPS

$8.40

$9.00

Cash provided by operations

At least $1.3 billion

Capital expenditures

Approximately $400 million

(a)

Excludes COVID-19 testing.

Note on Non-GAAP Financial Measures

As used in this press release the term "reported" refers to measures under accounting principles generally accepted in the United States ("GAAP"). The term "adjusted" refers to non-GAAP operating performance measures that exclude special items such as restructuring and integration charges, certain financial impacts resulting from the COVID-19 pandemic, amortization expense, excess tax benefits ("ETB") associated with stock-based compensation, costs associated with donations, contributions, and other financial support through Quest for Health Equity (our initiative with the Quest Diagnostics Foundation to reduce health disparities in underserved communities), gains and losses associated with changes in the carrying value of our strategic investments, a gain on sale of an ownership interest in a joint venture, and other items.

Non-GAAP adjusted measures are presented because management believes those measures are useful adjuncts to GAAP results. Non-GAAP adjusted measures should not be considered as an alternative to the corresponding measures determined under GAAP. Management may use these non-GAAP measures to evaluate our performance period over period and relative to competitors, to analyze the underlying trends in our business, to establish operational budgets and forecasts and for incentive compensation purposes. We believe that these non-GAAP measures are useful to investors and analysts to evaluate our performance period over period and relative to competitors, as well as to analyze the underlying trends in our business and to assess our performance. The additional tables attached below include reconciliations of non-GAAP adjusted measures to GAAP measures.

Conference Call Information

Quest Diagnostics will hold its quarterly conference call to discuss financial results beginning at 8:30 a.m. Eastern Time today. The conference call can be accessed by dialing 888-455-0391 within the U.S. and Canada, or 773-756-0467 internationally, passcode: 7895081; or via live webcast on our website at www.QuestDiagnostics.com/investor. We suggest participants dial in approximately 10 minutes before the call.

A replay of the call may be accessed online at www.QuestDiagnostics.com/investor or, from approximately 10:30 a.m. Eastern Time on February 2, 2023 until midnight Eastern Time on February 16, 2023, by phone at 888-566-0462 for domestic callers and 203-369-3609 for international callers. Anyone listening to the call is encouraged to read our periodic reports, on file with the Securities and Exchange Commission, including the discussion of risk factors and historical results of operations and financial condition in those reports.

PTC Therapeutics to Participate at Upcoming Investor Conference

On February 2, 2023 PTC Therapeutics, Inc. (NASDAQ: PTCT) reported that the company will present a company overview at the following conference (Press release, PTC Therapeutics, FEB 2, 2023, View Source [SID1234626775]).

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SVB Securities Global Biopharma Conference
Tuesday, Feb. 14 at 9:20 a.m. EST

The presentation will be webcast live on the Events and Presentations page under the Investor section of PTC Therapeutics’ website at View Source and will be archived for 30 days following the presentation. It is recommended that users connect to PTC’s website several minutes prior to the start of the webcast to ensure a timely connection.

Promontory Therapeutics to Present Clinical Trial for PT-112 in Prostate Cancer at the ASCO 2023 Genitourinary Cancers Symposium

On February 2, 2023 Promontory Therapeutics Inc., a clinical stage pharmaceutical company advancing small molecule immunotherapies in oncology, reported that it will present a poster on its clinical trial in progress of PT-112, its lead therapeutic candidate, in patients with late-stage metastatic castration-resistant prostate cancer, to be held at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) 2023 Genitourinary Cancers (ASCO GU) Symposium. ASCO (Free ASCO Whitepaper) GU will take place in San Francisco and online on Feb. 16-18, 2023 (Press release, Promontory Therapeutics, FEB 2, 2023, View Source [SID1234626774]).

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Poster Session Details
Title: A phase 2 study of immunogenic cell death inducer PT-112 in patients with metastatic castration-resistant prostate cancer.
Abstract Number: TPS292
Session Information: Trials in Progress Poster Session A: Prostate Cancer
Session Date: Thursday, Feb. 16, 2023
Speaker/Lead Author: Alan Bryce, MD

Abstracts will be published online on the ASCO (Free ASCO Whitepaper) GU website at 5:00 p.m. EST on Monday, Feb. 13.

For more information about PT-112 and Promontory Therapeutics’ clinical pipeline visit www.PromontoryTx.com. Further details on the PT-112 clinical trial in prostate cancer (NCT02266745) can be found at clinicaltrials.gov.

About PT-112

PT-112 is the first small-molecule conjugate of pyrophosphate in oncology, and possesses a unique pleiotropic mechanism of action that promotes immunogenic cell death (ICD), through the release of damage associated molecular patterns (DAMPs) that bind to dendritic cells and lead to downstream immune effector cell recruitment in the tumor microenvironment. PT-112 represents a highly potent inducer of this immunological form of cancer cell death. Further, PT-112 harbors a property known as osteotropism, or the propensity of the drug to reach its highest concentrations in certain areas of the bone, making it a candidate for treatment of patients with cancers that originate in, or metastasize to, the bone. The first in-human study of PT-112 demonstrated an attractive safety profile and evidence of long-lasting responses among heavily pre-treated patients and won "Best Poster" within the Developmental Therapeutics category at the ESMO (Free ESMO Whitepaper) 2018 Annual Congress. The combination Phase 1b dose escalation study of PT-112 with PD-L1 checkpoint inhibitor avelumab in solid tumors was reported in an oral presentation at the ESMO (Free ESMO Whitepaper) 2020 Virtual Congress and the Phase 2a dose confirmation cohort in non-small cell lung cancer (NSCLC) patients was reported at ESMO (Free ESMO Whitepaper) I-O 2022. The Phase 1 study in patients with relapsed or refractory multiple myeloma presented at ASH (Free ASH Whitepaper) 2020 is the third completed Phase 1 study of PT-112. Monotherapy Phase 2 development is ongoing in mCRPC, and includes the Phase 2 proof of concept study in thymic epithelial tumors under the company’s formal CRADA with the NCI.

Mersana Therapeutics to Present at Upcoming Investor Conferences

On February 2, 2023 Mersana Therapeutics, Inc. (NASDAQ: MRSN), a clinical-stage biopharmaceutical company focused on discovering and developing a pipeline of antibody-drug conjugates (ADCs) targeting cancers in areas of high unmet medical need, reported that members of management will present at the following upcoming investor conferences (Press release, Mersana Therapeutics, FEB 2, 2023, View Source [SID1234626772]).

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Guggenheim Oncology Conference
Format: Fireside Chat
Date/Time: Wednesday, February 8, 2023, at 2:10 p.m. Eastern Time

SVB Securities Global Biopharma Conference
Format: Fireside Chat
Date/Time Wednesday, February 15, 2023, at 1:00 p.m. Eastern Time

Cowen 43rd Annual Health Care Conference
Format: Panel Discussion
Date/Time: Wednesday, March 8, 2023, at 9:10 a.m. Eastern Time

Oppenheimer 33rd Annual Healthcare Conference
Format: Presentation
Date/Time: Tuesday, March 14, 2023, at 12:00 p.m. Eastern Time

Live webcasts of these events will be available on the Investors & Media section of Mersana’s website at www.mersana.com. Archived replays will be available for approximately 90 days following the events.

Leidos to Participate in the Cowen 44th Annual Aerospace/Defense & Industrials Conference

On February 2, 2023 Leidos (NYSE: LDOS), a FORTUNE 500 science and technology leader, reported that it will participate in the Cowen 44th Annual Aerospace/Defense & Industrials conference being held in Arlington, VA (Press release, Leidos, FEB 2, 2023, View Source;Industrials-Conference/default.aspx [SID1234626771]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Roger Krone, Chief Executive Officer, will engage in a question and answer "fireside chat" on February 15, 2023, at 2:05 p.m. ET.

A live audio webcast of the event will be available on the Leidos Investor Relations website at View Source A replay of the webcast will be available following the presentation at the same link listed above for 30 days afterward.