Blueprint Medicines Announces CEO and Leadership Transition Plan

On January 5, 2022 Blueprint Medicines Corporation (NASDAQ: BPMC) reported that its Board of Directors has appointed Kate Haviland to succeed Jeff Albers as Chief Executive Officer (CEO), effective April 4, 2022 (Press release, Blueprint Medicines, JAN 5, 2022, View Source [SID1234598208]). At that time, Mr. Albers will transition from his current role as Chairman, President and CEO to Executive Chairman of the Board of Directors and Ms. Haviland will transition from her current role as Chief Operating Officer (COO) to President and CEO. In addition, Ms. Haviland will be appointed to serve on the company’s Board of Directors, effective April 4, 2022.

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Blueprint Medicines also announced today that Christina Rossi has been promoted from Chief Commercial Officer to COO. In her new role, Ms. Rossi will retain leadership of global commercial strategy and operations, and expand her oversight to include portfolio strategy and program management, corporate development, and corporate affairs, effective April 4, 2022.

"Serving as CEO of Blueprint Medicines for the last eight years has been the highlight of my career, and I’m immensely proud of all that we’ve accomplished in our efforts to improve and extend the lives of patients," said Jeff Albers, Chairman, President and CEO of Blueprint Medicines. "Today, Blueprint Medicines is a fully integrated, global company delivering approved medicines to patients around the world. With a foundation of R&D and commercial success and an exciting pipeline of therapeutic candidates positioned to drive the company’s next phase of transformational growth, it is the right time for me to transition leadership to Kate and our outstanding executive team."

Mr. Albers continued, "I have known Kate for nearly two decades and have valued her expertise and leadership throughout our time working together at Blueprint Medicines. Since joining the company six years ago, Kate has touched all aspects of our business and has been a steadfast partner in charting the company’s course through both successes and setbacks. She is adept at identifying and pursuing opportunities for growth and managing resource allocations across our broad portfolio, while also driving a high-performance culture anchored in transparency and a commitment to a diverse and inclusive workforce."

"The Board’s selection of Kate as our next CEO is the culmination of a thoughtful, long-term succession planning process that was led by Jeff and the Board and purposefully designed to drive the company’s continued success, ensure continuity, and empower our strong executive team. Kate is an exceptional leader with a clear and inspiring vision, demonstrated ability to lead and execute an integrated business strategy, and deep commitment to our patient-centric mission and culture of innovation. The Board is confident in her ability to lead the company to reach its full potential through our next phase of growth and beyond," said Alexis Borisy, co-founder and member of the Board of Directors of Blueprint Medicines. "On behalf of the Board, I want to thank Jeff for his remarkable leadership as CEO. During his tenure, the company has achieved tremendous success, developing from a privately held preclinical enterprise into a leading independent precision therapy company. It has been a privilege to be part of the company’s exponential growth, and I look forward to working with Kate and Jeff as the company continues to deliver important, innovative medicines to patients globally."

"I am excited to become CEO of Blueprint Medicines as we build on our success by advancing the ongoing commercial launch of AYVAKIT (avapritinib) in advanced systemic mastocytosis, achieving a constellation of near-term clinical data milestones for multiple therapeutic candidates, and expanding our portfolio with promising new research programs that we believe will drive substantial growth over the long term," said Kate Haviland. "Blueprint Medicines was founded with a vision to change the lives of patients who have received a devastating diagnosis of cancer or hematologic disease. I have been honored to be a part of the team that has made this vision a reality. Over the years, I have met many patients and families whose lives have been impacted and extended by our efforts. I am driven by these experiences to expand the impact Blueprint Medicines can have on more people and families across the globe who are looking to us with hope for a better future. I look forward to continuing to work with Jeff, as he steps into the Executive Chairman role, the Board, and our executive team. Most importantly, I’m thrilled to lead and work side-by-side with our employees at Blueprint Medicines, a team that is passionate and deeply committed to continuously driving and delivering medical innovation."

Ms. Haviland joined Blueprint Medicines in January 2016 as Chief Business Officer and has served as Chief Operating Officer since January 2019. Over this time, she served as the founding chair of the portfolio management team, formed and executed business development strategy, drove global capital investment plans, and played a key role in capital market financings. In addition, she directly supported the company’s evolution into a fully integrated business by developing and providing ongoing management of critical functions, including portfolio strategy and program management, corporate development, commercial strategy, international, technical operations, corporate affairs, and information systems. Prior to joining Blueprint Medicines, Ms. Haviland held leadership roles focused on building emerging, high-growth companies and advancing the development of innovative therapies in oncology and rare diseases as Vice President, Rare Diseases and Oncology Program Leadership at Idera Pharmaceuticals, Head of Commercial Development at Sarepta Therapeutics, Executive Director of Commercial Development at PTC Therapeutics, and roles in both corporate development and project management at Genzyme. She holds a B.A. from Wesleyan University with a double major in Biochemistry/Molecular Biology and Economics and an M.B.A. from Harvard Business School. Ms. Haviland has served as an independent director on the board of Fulcrum Therapeutics since June 2018 and is a member of the audit and compensation committees.

As part of the succession plan, Mr. Albers has agreed to serve as Executive Chairman through the end of 2022, with continued service as Chairman thereafter, with the goal of enabling a seamless leadership transition as the company continues to execute on its growth strategy.

bluebird bio to Present at the 40th Annual J.P. Morgan Healthcare Conference

On January 5, 2022 bluebird bio, Inc. (Nasdaq: BLUE) reported that members of the management team will present at the virtual 40th Annual J.P. Morgan Healthcare Conference, Wednesday, January 12, at 3:45 p.m. ET (Press release, bluebird bio, JAN 5, 2022, View Source [SID1234598206]).

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To access the live webcast of bluebird bio’s presentation, please visit the "Events & Presentations" page within the Investors & Media section of the bluebird bio website at View Source A replay of the webcast will be available on the bluebird bio website for 30 days following the event.

Black Diamond Therapeutics to Present at the 40th Annual J.P. Morgan Healthcare Conference

On January 5, 2021 Black Diamond Therapeutics, Inc. (Nasdaq: BDTX), a precision oncology medicine company pioneering the discovery and development of MasterKey therapies, reported that its President and Chief Executive Officer, David M. Epstein, Ph.D., will present an update on the Company’s progress at the 40th Annual J.P. Morgan Healthcare Conference being held virtually on Wednesday, January 12, 2022 at 9:00 a.m. ET (Press release, Black Diamond Therapeutics, JAN 5, 2022, View Source [SID1234598205]).

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A live webcast of the presentation can be accessed by visiting the investor relations section of the Company’s website, www.blackdiamondtherapeutics.com. A replay of the presentation will also be available and archived on the site for 30 days.

Bio-Path Holdings to Present at H.C. Wainwright BioConnect 2022 Virtual Conference

On January 5, 2022 Bio-Path Holdings, Inc., (NASDAQ: BPTH), a biotechnology company leveraging its proprietary DNAbilize antisense RNAi nanoparticle technology to develop a portfolio of targeted nucleic acid cancer drugs, reported that Peter Nielsen, Chief Executive Officer, will participate in a pre-recorded presentation at the H.C. Wainwright BioConnect 2022 Virtual Conference made available on Monday, January 10, 2022 at 7:00 a.m. ET (Press release, Bio-Path Holdings, JAN 5, 2022, View Source [SID1234598204]).

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An audio webcast of the presentation will be available here and on the Investor Relations section of Bio-Path’s website, where it will be archived for approximately 90 days.

Bicycle Therapeutics Announces Continued Clinical Progress and Updates to Management Team

On January 5, 2022 Bicycle Therapeutics plc (NASDAQ: BCYC), a biotechnology company pioneering a new and differentiated class of therapeutics based on its proprietary bicyclic peptide (Bicycle) technology, reported continued progress in its ongoing Phase I/II clinical trials of BT8009, BT5528 and BT7480 (Press release, Bicycle Therapeutics, JAN 5, 2022, View Source [SID1234598203]).

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"Last quarter, we reported interim clinical results from ongoing trials of two of our Bicycle toxin conjugates, BT8009 and BT5528, demonstrating preliminary anti-tumor activity in two tumor types, and announced the first patient dosed in the Phase I clinical trial of BT7480, our first tumor-targeted immune cell agonist to enter the clinic. In our trial of BT8009, we are pleased to confirm the preliminary activity and see that these patients remain on trial. We look forward to presenting interim BT8009 Phase I results at a medical meeting and initiating the BT5528 expansion cohorts this year," said Kevin Lee, Ph.D., Chief Executive Officer. "We are also pleased with our progress advancing BT7480 in the ongoing Phase I clinical trial and look forward to sharing additional details regarding the potential for Bicycles beyond our toxin conjugates as we strive to become a leader in the development of targeted oncology therapeutics."

Bicycle Toxin Conjugates (BTCs) BT8009 and BT5528

In the ongoing Phase I portion of the Phase I/II clinical trial of BT8009, a second-generation BTC targeting Nectin-4, four out of 11 patients were previously reported to have a partial response under Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1, including one out of four (25%) in the 2.5mg/m2 dose and three out of seven (43%) at the 5.0 mg/m2 cohorts. All four patients previously reported as responders have since received at least one subsequent scan, and all have been confirmed as ongoing RECIST 1.1 responses. One patient in the 5.0 mg/m2 cohort, who previously was reported to have a partial response with an 89% tumor reduction, has now received two subsequent scans, which each showed that total tumor volume has been reduced by 100%, constituting a confirmed complete response. All four patients previously reported to have a RECIST 1.1 clinical response remain on therapy. The tolerability profile of the 2.5mg/m2 and 5.0 mg/m2 cohorts remains consistent with that previously reported.

Dose escalation in the BT8009 Phase I trial remains ongoing, with patients currently being dosed at 7.5mg/m2 weekly or every-other-week. Bicycle intends to present interim Phase I results from the ongoing clinical trial at a medical meeting this year.

The Phase I/II trial of BT5528, Bicycle’s second-generation BTC targeting EphA2, is also ongoing, with plans remaining on track to initiate the expansion cohorts this year, with an expected recommended Phase II dose of 6.5mg/m2 every-other-week.

Bicycle tumor-targeted immune cell agonist (Bicycle TICA) BT7480

Bicycle also initiated a Phase I clinical trial of BT7480, a novel, fully synthetic Bicycle TICA targeting Nectin-4 and agonizing CD137, in the fourth quarter of 2021, and dose escalation in that trial remains ongoing. BT7480 and other Bicycle TICAs, including a novel NK-cell-engaging molecule, were the subjects of four posters at SITC (Free SITC Whitepaper) in November 2021.

Management Team Updates

Bicycle is also announcing the expansion of and transition in its management team. Michael Skynner, Ph.D., the company’s Chief Operating Officer (COO), has been appointed to the newly created position of Chief Technology Officer, effective January 3, 2022, to focus on leading and overseeing the growth of Bicycle’s proprietary phage display discovery platform in oncology, as well as on creating innovative opportunities for the platform outside of oncology. Dr. Skynner joined the company in January 2016 as Vice President, Operations and Discovery and had served as COO since March 2018. Alistair Milnes, who has served as the company’s Vice President, Human Resources and Communications since January 2021, has assumed the COO role. Mr. Milnes previously led human resources and communications at multinational energy and mineral companies. Both Dr. Skynner and Mr. Milnes are based in the United Kingdom.

"We are delighted to announce our recent management team appointments, with Mike Skynner becoming our new CTO and Alistair Milnes moving to the COO role. Mike has been an invaluable contributor to Bicycle’s success to date and has led our platform discovery efforts since joining in early 2016. Following recent promising clinical progress, we believe it is time to focus on accelerating the growth of our proprietary oncology pipeline and on identifying innovative ways to potentially capitalize on our unique technology beyond our current therapeutic focus. I am confident that Mike can help us achieve these objectives." Dr. Lee added, "I am similarly enthusiastic about Alistair’s appointment as COO and believe his operational experience and track record of successfully identifying, recruiting, and retaining key talent at large, multinational companies will be instrumental in helping guide Bicycle through our next phase of growth."