On December 1, 2022 Herantis Pharma Plc ("Herantis") developing disease modifying therapies for Parkinson’s disease, reported that it has applied for delisting of its shares from Nasdaq First North Growth Market Sweden ("Nasdaq FN GM Sweden") (Press release, Herantis Pharma, DEC 1, 2022, View Source,c3676089 [SID1234624649]).

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When adopting the decision on applying for the delisting, the Board of Directors considered the development of trading since the company listed its shares on Nasdaq FN GM Sweden in 2019, noting the low level of trading volumes as well as the small number of current shareholders holding their shares through Euroclear Sweden AB. The Company has also considered the additional costs related to maintaining this secondary listing for a company of its size as well as the administrative burden of complying with the listing rules of another market in addition to its home market in Finland.

The Company wants to remind Herantis’ shareholders holding their shares through Euroclear Sweden AB that even while the listing of Herantis’ shares on Nasdaq FN GM Sweden will be discontinued, such shareholders can continue trading in Herantis’ shares on Nasdaq First North Growth Market Finland by first arranging for the cross-border settlement of their shares into the book-entry system maintained by Euroclear Finland Oy. In order to effectuate such cross-border settlement, the shareholders should contact their respective custodian or Herantis Issuing Agent Aqurat Fondkommission AB ([email protected]) for more information.

The last day of trading on Nasdaq FN GM Sweden is expected to be January 31, 2023. More information about the delisting will be provided once Nasdaq Sweden has decided on the application.

On December 1, 2022 CRISPR Therapeutics (Nasdaq: CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, reported that members of its senior management team are scheduled to participate in a fireside chat at the 2022 BMO Growth & ESG Conference on Wednesday, December 7, 2022, at 1:00 p.m. ET (Press release, CRISPR Therapeutics, DEC 1, 2022, View Source [SID1234624648]).

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A replay of the webcast will be archived for 14 days following the presentation on the "Events & Presentations" page in the Investors section of the Company’s website at View Source

On December 1, 2022 Deciphera Pharmaceuticals, Inc. (NASDAQ: DCPH) reported that Steve Hoerter, President and Chief Executive Officer, will participate in a virtual fireside chat at the JMP Securities Hematology and Oncology Summit on Tuesday, December 6, 2022 at 10:40 AM ET (Press release, Deciphera Pharmaceuticals, DEC 1, 2022, View Source [SID1234624644]).

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A live webcast of the fireside chat will be available on the "Events and Presentations" page in the "Investors" section of the Company’s website at View Source A replay will be archived on the Company’s website for 90 days following the presentation.

On December 1, 2022 Compugen Ltd. (Nasdaq: CGEN), a clinical-stage cancer immunotherapy company and a pioneer in computational target discovery, announced today publication of abstracts by ESMO (Free ESMO Whitepaper)-IO showing that at the time of abstract data cutoff, Compugen’s COM701 (anti-PVRIG) in dual and triple combination with nivolumab ± BMS-986207 demonstrated preliminary anti-tumor activity and immune activation in platinum resistant ovarian cancer patients and was well tolerated (Press release, Compugen, DEC 1, 2022, View Source [SID1234624643]).

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The Company plans to host a conference call and webcast on Wednesday, December 7, 2022, at 8:30 AM ET to review its preliminary clinical data from dual and triple combination of COM701+ nivolumab ± BMS-986207 in platinum resistant ovarian cancer patients and its COM701 ± nivolumab in metastatic NSCLC patients to be presented at ESMO (Free ESMO Whitepaper)-IO, December 8, 2022, Geneva, Switzerland. Abstracts are available today on the ESMO (Free ESMO Whitepaper)-IO website and posters with longer follow-up data will be available on the ESMO (Free ESMO Whitepaper)-IO virtual platform, in the e-Poster section on December 6, 2022.

"Platinum resistant ovarian cancer patients are in urgent need of new treatment options. Current standard of care, single agent chemotherapy, is characterized by toxicity and low activity and recently approved ADC therapy is restricted to a subset of the population and limited by ocular toxicity. So far immune checkpoint inhibitors showed limited activity especially in PD-L1 low expressors, where the unmet need is the greatest," said Anat Cohen-Dayag, Ph.D., President, and CEO of Compugen. "At ESMO (Free ESMO Whitepaper)-IO we will present encouraging preliminary anti-tumor activity supported by immune activation and favorable safety profile following the dual and triple blockade of PVRIG, PD-1 ± TIGIT in platinum resistant ovarian cancer patients. The full data to be presented at the conference remain under embargo until December 6, 2022 and will contain longer follow up. We are looking forward to discussing this data along with our NSCLC data which will also be presented at ESMO (Free ESMO Whitepaper)-IO, in addition to our plans going forward, during our investor call on December 7, 2022."

The abstracts are published today on the ESMO (Free ESMO Whitepaper)-IO website, and the publication section of Compugen’s website. On December 6, 2022, posters with longer follow-up data will be available on the e-Poster section of the ESMO (Free ESMO Whitepaper)-IO virtual platform and the publication section of Compugen’s website.

On December 1, 2022 BRIM Biotechnology, Inc. ("BRIM," TPEx 6885), a clinical-stage biotechnology company advancing novel regenerative therapies to help combat and cure ophthalmology and degenerative joint diseases, reported that it has raised $20 million in its Series E funding round (Press release, BRIM Biotechnology, DEC 1, 2022, View Source [SID1234624642]). This demonstrates the heightened interest and growing demand for new treatments for Dry Eye Disease (DED). News of this latest funding round comes as BRIM prepares to initiate the Phase 3 clinical trial for its lead asset BRM421 for DED in the US.

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Since the company’s inception in 2013, BRIM has successfully developed several platform technologies, including the regenerative peptide technology (PDSP) upon which the lead asset BRM421 for the Phase 3 clinical trial is based. Two of the platforms were spun out as a new company, Ascendo Biotechnology, to reshape the future of immunotherapeutics. This series E funding investment will be used to accelerate the development of BRIM’s diverse pipeline of wholly-owned drug candidates as well as to invest in new innovation, leveraging BRIM’s extensive translation research experience.

"We are tackling chronic, life-limiting diseases using our proprietary stem cell regenerative Pigment Epithelium-Derived Factor (PEDF) derived Short Peptide (PDSP) technology platform to not only alleviate symptoms but to address and repair the damage caused by diseases. This funding round is the latest in a series of funding that has been planned strategically to enable the company to achieve its core mission of advancing discoveries into disease-modifying treatments that transform patients’ lives. We are unwavering in our commitment to bringing sustainable and affordable healthcare to the world. The oversubscribed interest from investors is an endorsement of BRIM’s solid foundations built on the strength of our team, our expertise in translational science, and the progress of our development programs to date. We look forward to initiating the Phase 3 clinical trial for BRM421 for Dry Eye Disease at this exciting time of new growth," said Dr. Haishan Jang, the founder, Chairwoman and CEO of BRIM.

As of today, BRIM has submitted BRM421’s Phase 3 study protocol to the FDA and is ready to initiate the Phase 3 clinical trial as early as the end of this year. Founded in Taiwan, BRIM has over 70 global IPs for the PDSP platform and quality operation to meet international regulatory standards.