On December 6, 2022 ANDARIX Pharmaceuticals, a leader in the discovery and development of targeted peptide therapy for cancer reported that it will present its clinical strategy and results at the upcoming clinical trials in rare diseases conference (Press release, Andarix Pharmaceuticals, DEC 7, 2022, View Source [SID1234624880]). The Clinical Trials in Rare Diseases Conference 2022 is focused on exploring the challenges and opportunities for planning and conducting clinical studies in rare disease. The virtual conference will take place on December 7, 2022.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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About Tozaride
Tozaride is a novel, best-in-class cancer therapy based on a radio-labeled somatostatin peptide analogue. Early clinical studies of Tozaride demonstrated that it is well tolerated and may produce prolonged stable disease and improved overall survival in advanced lung cancer patients whose disease has continued to progress after failing other therapies. Tozaride targeted radiotherapy represents a new treatment paradigm which is expected to yield significant clinical benefit for both lung cancer (SCLC, NSCLC), and pancreatic cancer patients. Along with its companion diagnostic that helps identify patients most likely to respond – those with sufficient expression of the peptide’s target – Tozaride could provide another treatment option for patients who are not eligible for, or who have not responded to current therapies.

On December 7, 2022 Targovax ASA reported that members of its executive management team are invited to present at following upcoming conferences (Press release, Targovax, DEC 7, 2022, View Source [SID1234624874]):

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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7th Annual Oncolytic Virotherapy Summit, Boston, USA
Date: 7 December 2022
Presenter: Erik Digman Wiklund, CEO
Time: 12:00 EDT / 18:00 CET

DNB Nordic Healthcare Conference, Oslo, Norway
Date: 15 December 2022
Presenter: Erik Digman Wiklund, CEO
Time: 15:10 CET

Biotech Showcase, J.P. Morgan Healthcare week
Date: 9-12 January 2023
Attending: Erik Digman Wiklund, CEO, Lubor Gaal, CFO

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For further information, please contact:
Erik Digman Wiklund, CEO
Phone: +47 413 33 536
Email: [email protected]

Renate Birkeli, Investor Relations
Phone: +47 922 61 624
Email: [email protected]

Media enquires:
Andreas Tinglum – Corporate Communications (Norway)
Phone: +47 9300 1773
Email: [email protected]

On December 7, 2022 Herantis Pharma Plc ("Herantis"), developing disease modifying therapies for Parkinson’s disease, reported that CEO, Antti Vuolanto will participate and give a company presentation at (Press release, Herantis Pharma, DEC 7, 2022, View Source,c3678469 [SID1234624873]):

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Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Inderes Life Science evening

Date: December 13, 2022

Location: Helsinki, Finland

For more information, please contact:

Julie Silber/Gabriela Urquilla

Tel: +46 (0)7 93 486 277/+46 (0)72-396 72 19

Email: [email protected]

On December 7, 2022 Touchlight, a biotechnology company pioneering enzymatic DNA production to enable genetic medicines, reported a development and supply agreement with Odimma Therapeutics, a French biotech company focusing on personalised cancer immunotherapy (Press release, Touchlight Genetics, DEC 7, 2022, View Source [SID1234624862]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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"The agreement between Odimma and Touchlight is an important step forward to secure Odimma’s clinical development. Not only is Touchlight’s technology producing genetic material with very favourable characteristics for a clinical use but also in a timeframe extremely adapted to a personalized immunotherapy in oncology. "

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The agreement focuses on the provision of clinical material for use in Odimma’s oncological neoantigen program. Through the deal, Odimma will gain access to Touchlight’s proprietary doggybone DNA (dbDNA) vector technology, providing them with a clinical supply of personalised dbDNA, to support and underpin the development of their candidate immunotherapy cancer treatment. The program is expected to start clinical enrolment in 2023.

Odimma’s approach of harnessing the ability of the patient’s own immune system to specifically recognize non-self-targets displayed by tumour cells represents a step change in the field of immune oncology and opens new avenues for the treatment of difficult to target tumours.

The development of the neoantigen products required for the therapy has faced unique challenges, including lead time to obtain GMP DNA and complex supply chains. Touchlight’s enzymatic production process, with its 5-day manufacturing process, will therefore strongly support Odimma in its program development. This will also allow Odimma’s clinical study to commence promptly for the benefit of patients.

Touchlight’s doggybone DNA is a minimal, linear, double stranded, covalently closed DNA vector which is produced through an enzymatic manufacturing process. It can accommodate genes of interest of more than 20kb and is linearly scalable, making it highly adaptable to support a range of genetic medicines and is ideal for the development of mRNA vaccines, therapeutics, gene therapies and beyond.

Karen Fallen, CEO, Touchlight commented: "We are delighted to be supporting Odimma on this ground-breaking program. Innovation in enzymatic DNA manufacturing is enabling advancements such as Odimma’s Immunotherapy program to deliver treatments to critically ill patients. With a rapid timeline to GMP and high-fidelity process, doggybone DNA is helping to overcome existing industry bottlenecks and the challenges associated with plasmid DNA."

Jean-Marc Limacher, MD, Chairman of Odimma Therapeutics said: "The agreement between Odimma and Touchlight is an important step forward to secure Odimma’s clinical development. Not only is Touchlight’s technology producing genetic material with very favourable characteristics for a clinical use but also in a timeframe extremely adapted to a personalized immunotherapy in oncology.

On December 7, 2022 Enterome, a clinical stage biopharmaceutical company developing first-in-class immunomodulatory drugs based on its gut bacterial Mimicry drug discovery platform, reported that it will present updated efficacy, immunogenicity and safety data from its Phase 2 trial of EO2401 in combination with nivolumab +/- bevacizumab, in patients with first progression/recurrence of glioblastoma (ROSALIE trial) in two poster presentations at the ESMO (Free ESMO Whitepaper) Immuno-Oncology Congress which is taking place in Geneva, Switzerland, December 7-9 2022 (Press release, Enterome, DEC 7, 2022, View Source [SID1234624857]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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EO2401 is a first-in-class OncoMimics peptide-based immunotherapy able to rapidly activate and significantly expand existing effector memory CD8+ T cells against tumor-associated driver antigens due to their strong cross-reactivity with OncoMimics peptides.

Professor Wolfgang Wick, Universitätsklinikum and German Cancer Research Center, Heidelberg (Germany) will present the two posters on Thursday December 8th at the Poster Display Session ID 44 from 12:30 to 13:15 CET.

The poster details are as follows:

Poster Details – Abstract #170P
Title: EO2401 microbiome derived therapeutic vaccine + nivolumab +/- bevacizumab, in neoadjuvant, adjuvant and non-surgery linked treatment of recurrent glioblastoma: phase 1-2 EOGBM1-18/ROSALIE study
Authors: W. Wick et al.

Link to abstract can be accessed here.

Poster Details – Abstract #185P
Title: Interim analysis of the EOGBM1-18 study: Strong immune response to therapeutic vaccination with EO2401 microbiome derived therapeutic vaccine + nivolumab
Authors: W. Wick et al.

Link to abstract can be accessed here.

In addition, Enterome will present another poster on in vitro assays and in vivo evaluations in healthy donors demonstrating that OncoMimics peptides can elicit strong immune responses against tumors through cross-reaction of pre-existing, highly prevalent (>80% in the population) CD8+ T cells against targeted Tumor-Associated Antigens (TAAs).

Poster Details – Abstract #180P
Title: Recalling pre-existing microbiota-specific T cells to target tumors
Authors: J.-M. Carpier et al.

Link to abstract can be accessed here.

About EO2401
EO2401 is Enterome’s first-in-class off-the-shelf OncoMimics peptide-based immunotherapy. It combines three microbial-derived OncoMimics peptides that closely mimic specific cytotoxic T cell (CD8+ T cell) epitopes on the Tumor-Associated Antigens IL13Ra2, BIRC5 and FOXM1, combined with the helper peptide (CD4+ T cell epitope) Universal Cancer Peptide 2 (UCP2). EO2041 is designed to trigger the immune system into recognizing these epitopes on glioblastoma cells as foreign (non-self) and eliciting a targeted memory T-cell driven cell-killing response against the tumor cells.

About ROSALIE
ROSALIE (EOGBM1-18, NCT04116658) is a multicenter, open-label, Phase 1/2 trial investigating EO2401 in combination with nivolumab, and in combination with nivolumab/bevacizumab in patients with glioblastoma at first progression/recurrence after surgery and adjuvant radiotherapy/temozolomide. The trial is assessing safety, tolerability, immunogenicity and preliminary efficacy in more than 80 patients at centers in the US and Europe.