Addex Increases Issued Share Capital to Create Treasury Shares

On November 1, 2022 Addex Therapeutics (SIX: ADXN and Nasdaq: ADXN), a clinical-stage pharmaceutical company pioneering allosteric modulation-based drug discovery and development (the Company), reported that it has issued 32,636,476 new registered shares at a nominal value of CHF 0.01 each to Addex Pharma SA, its 100% wholly-owned subsidiary (Press release, Addex Therapeutics, NOV 1, 2022, View Source [SID1234622669]). The new shares, issued from the Company’s authorized capital, are listed on the SIX Swiss Exchange. The transaction has been executed to provide the Group with additional future financing flexibility. The total number of issued shares increased to 97,909,428 at a nominal value of CHF 0.01 each, whilst the outstanding shares remain unchanged.

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Swiss Takeover Board Decision
Upon completion of the above-described capital increase, Addex Pharma SA exceeded the offer threshold of 33 1/3% of the voting rights of the Company. Within this context, the Company has to publish the decision of the Swiss Takeover Board (the TOB) of August 18, 2022:

"The Takeover Board decides:

Addex Pharma SA is granted an exemption pursuant to Art. 136 para. 1 lit. c of the Financial Market Infrastructure Act (FMIA) from the obligation to make an offer pursuant to Art. 135 FMIA in respect of all listed shares of Addex Therapeutics Ltd in connection with the transaction described in this decision. This exemption from the obligation to make an offer is granted under the condition that (i) Addex Pharma SA reduces its shareholding in Addex Therapeutics Ltd to or below the threshold of 33 1/3% of the share capital in terms of voting rights by March 31, 2023 and that (ii) Addex Pharma SA does not exercise significant influence on the fate of Addex Therapeutics Ltd during the period in which it exceeds the threshold;

Addex Pharma is required to notify the Swiss Takeover Board within five trading days if it exceeds or falls below the threshold of 33.3% of the share capital and voting rights in Addex Therapeutics Ltd.

Addex Therapeutics Ltd is required to publish the provisions of the present decision as well as the reference to the right of objection of qualified shareholders pursuant to Art. 6 and 7 TOO.

This decision will be published on the website of the Swiss Takeover Board following the publication by Addex Therapeutics Ltd in accordance with clause 3 above.

The fees payable by Addex Pharma SA amount to CHF 20,000."

The Company’s Board of Directors has decided not to publish a separate report within the meaning of Article 61 para. 3 lit. a of the Takeover Ordinance.

Shareholders of the Company who have been holding at least 3% of the voting rights of the Company, whether exercisable or not (a "qualified participation"), since the date of publication of the decision, may file an objection against the decision of the TOB. The objection must be filed with the TOB (Stockerstrasse 54, 8002 Zurich; fax: +41 44 283 17 40) within five (5) trading days from the date of publication of the decision. The first trading day after the publication of the decision on the TOB’s website will be the first day of the filing period. The objection must contain a motion, summary reasons and proof of the qualified participation as from the date of the publication of the decision.

Sysmex Inostics Exhibits at Association of Molecular Pathologist 2022 Annual Meeting & Expo in Phoenix Arizona

On November 1, 2022 Sysmex Inostics Inc., a subsidiary of Japan’s Sysmex Corporation and Baltimore-based biotechnology firm and CLIA-certified lab, reported that it will exhibit at the Association of Molecular Pathologist (AMP) 2022 Annual Meeting & Expo in Phoenix Arizona from November 3, 2022, through November 5, 2022 (Press release, Sysmex Inostics, NOV 1, 2022, View Source [SID1234622668]). The company will exhibit at booth 701 and take meetings in Expo Hall room seven.

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Sysmex Inostics will unveil its new website, developed with the award-winning creative agency TRAINA, which echoes Sysmex Inostics’ efforts to deliver intelligent, scientific solutions with a human-centric focus on the boundless potential of every patient.

"As a world-class CLIA lab and liquid biopsy provider, we employ innovative diagnostic tools to fight life shattering diseases. We believe in enhancing every phase of a patient’s journey, from helping bring life-saving drugs to market and expanding treatment options, to giving patients the tools and information they need to live the fullest life possible," said Sysmex Inostics, CEO, Shinichi Sato.

"Our team is committed to changing outcomes for the better. We understand every molecule counts, every decision counts and every patient counts," concluded Sato.

Sysmex Inostics helped pave the way to personal, accurate treatment of devasting diseases through its ultra-sensitive liquid biopsy and biomarker analysis. By empowering actionable molecular discoveries with its next generation sequencing Plasma-Safe-SeqS technology tests and in the past with its venerable OncoBEAM technology, the company has played a significant role in solid tumor cancer and Acute Myeloid Leukemia (AML) discoveries serving the pharmaceutical, clinical, and research communities.

Sysmex Inostics has been active in 2022 with several noteworthy accomplishments:

Partnered with the Foundation of the National Institute of Health (FNIH) & Commenced New Ultra-Sensitive Leukemia Detection Test
In May, Sysmex Inostics partnered with FNIH to discover new modalities to detect and monitor AML Minimal Residual Disease (MRD) which has one of the worst cancer outcomes at a 31 percent 5-year relative survival rate.1

At the same time, Sysmex Inostics began to offer its AML-SEQ CLIA-validated testing service, a focused panel to detect mutations of the three most prevalent genes found in AML. The new test rounds out the company’s offerings with a less expensive test compared to the broader AML-MRD-SEQ for the detection of MRD in 68 regions across 20 genes launched in October 2021.

Launched Head & Neck Cancer CLIA Validated Testing Service
In February, Sysmex Inostics launched its Head & Neck Cancer CLIA-validated testing service, HNSCC sequencing, for cancers that are HPV-negative and driven by mutations in key genes. This test is complementary to the company’s HPV-SEQ service which can identify, quantify, and track HPV 16/18.

MannKind Corporation to Hold 2022 Third Quarter Financial Results Conference Call on November 8, 2022

On November 1, 2022 MannKind Corporation (Nasdaq: MNKD) reported that it will release its 2022 third quarter and year to date financial results and its management will host a conference call to discuss these results and corporate updates at 9:00 AM (Eastern Time) on Tuesday, November 8, 2022 (Press release, Mannkind, NOV 1, 2022, View Source [SID1234622667]).

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Presenting from the Company will be its Chief Executive Officer, Michael Castagna and Chief Financial Officer, Steven Binder.

Those interested in listening to the conference call live via the Internet may do so by visiting the Company’s website at View Source under Events & Presentations.

United Therapeutics Corporation to Present at the Credit Suisse 31st Annual Healthcare Conference

On November 1, 2022 United Therapeutics Corporation (Nasdaq: UTHR) reported that Patrick Poisson, Executive Vice President, Technical Operations, will provide an overview and update on the company’s business during a fireside chat session at the Credit Suisse 31st Annual Healthcare Conference in Los Angeles (Press release, United Therapeutics, NOV 1, 2022, View Source [SID1234622666]).

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The session will take place on Tuesday, November 8, 2022, from 12:50 p.m. to 1:20 p.m., Pacific Standard Time, and can be accessed via a live webcast on the United Therapeutics website at View Source An archived, recorded version of the session will be available approximately 24 hours after the session ends and can be accessed at the same location for 90 days.

Alligator Bioscience to Participate in Upcoming Scientific and Industry Conferences

On November 1, 2022 Alligator Bioscience (Nasdaq Stockholm: ATORX) reported that senior company representatives will participate in the following scientific and industry conferences during November and December 2022 (Press release, Alligator Bioscience, NOV 1, 2022, View Source [SID1234622665]):

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Festival of Biologics, November 2 – 4, Basel, Switzerland
Mattias Levin, PhD, Senior Team Manager, Antibody Engineering, at Alligator Bioscience, will give a presentation entitled "Neo-X-Prime: Bispecific Tumor Antigen Conditional CD40 Agonistic Antibodies" at 5:00 pm CET on November 3.

Registration for the conference is open here.
Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 37th Annual Meeting, November 8 – 12, Boston, United States
Malin Lindstedt, visiting professor at Alligator Bioscience and Professor at the Department of Immunotechnology at Lund University, will give a poster presentation entitled "Early pharmacodynamic changes measured by RNA sequencing in peripheral blood from patients in a phase 1 study with mitazalimab, a potent CD40 agonistic IgG1 monoclonal antibody", poster number 35, on November 10.

Ana Carneiro, Associate Professor and Consultant at Lund University, will give a poster presentation entitled "ATOR-1017, a 4-1BB antibody, demonstrates promising safety and proof of mechanism in a first-in-human study in patients with advanced solid malignancies", poster number 714, on November 11.

Registration for the conference is open here.
Jefferies 2022 London Healthcare Conference, November 15 – 17, London, United Kingdom
Søren Bregenholt, Chief Executive Officer of Alligator Bioscience, will attend in person to meet investors.
Redeye Life Science Day, November 24, Stockholm, Sweden
Søren Bregenholt, Chief Executive Officer of Alligator Bioscience, will present the company, its latest developments, and upcoming catalysts to investors.
Biostock Life Science Fall Summit 2022, November 29-30, Lund, Sweden
Søren Bregenholt, Chief Executive Officer of Alligator Bioscience, will give a corporate presentation followed by a Q&A session at 1:00 pm CET on November 30.

More information about the conference can be viewed here.
13th Annual DNB Nordic Healthcare Conference, December 15, Oslo, Norway
Søren Bregenholt, Chief Executive Officer of Alligator Bioscience, will present the company, its latest developments, and upcoming catalysts to investors.
The information was submitted for publication, through the agency of the contact person set out above, at 8:30 a.m. CET on November 1, 2022.