On October 5, 2022 Agenus (NASDAQ: AGEN), an immuno-oncology company with an extensive pipeline of therapeutics designed to activate the immune response to cancers and infections, reported it will host an in-person and virtual Research & Development event ("The Road Taken") on Saturday, November 12, 2022, from 2:00 p.m. to 5:00 p.m. ET at the Prudential Tower in Boston, MA (Press release, Agenus, OCT 5, 2022, View Source [SID1234621737]).

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The Road Taken will feature both key opinion leaders at the forefront of immunotherapy development for cancer and Agenus’ expanding leadership team. During the event, speakers will highlight recent developments within the Agenus clinical-stage pipeline of novel immunotherapy programs, study details involving botensilimab, a multi-functional Fc-enhanced anti-CTLA-4 which activates innate and adaptive immune responses, opportunities to combine Agenus pipeline assets to overcome immuno-oncology resistance and strategies to reach commercialization as rapidly as possible.

Featured speakers will include:

Michael Atkins, MD, Deputy Director & Professor, Acting Chief, Division of Hematology/Oncology MedStar Georgetown University Hospital; SITC (Free SITC Whitepaper) 2022 Lifetime Achievement Award Recipient
Breelyn Wilky, MD, Director of Sarcoma Medical Oncology, Deputy Associate Director for Clinical Research University of Colorado Medicine; Principal Investigator/Presenter C-800 Study
Steven O’Day, MD, Chief Medical Officer, Agenus
Joseph Grossman, MD, VP and Head of Exploratory Medicines, Agenus
Patricia Carlos, Chief Regulatory, Quality, and Safety Officer, Agenus
The scientific program will take place from 2:00 p.m. to 4:00 p.m. ET and will be followed by a reception from 4:00 p.m. to 5:00 p.m. ET.

The event will be webcast live and institutional investors and research analysts are invited to attend in person. Individuals interested in attending the event in person should contact Agenus Investor Relations at [email protected]. The webcast will be available on the Investors section of the Agenus website at investor.agenusbio.com. To register for the webcast, please click here. Following the webcast, an archived version will be available on the Agenus website.

On October 5, 2022 ChemoCentryx, Inc., (Nasdaq: CCXI), reported two upcoming poster presentations for CCX559, the Company’s investigational, highly potent, orally administered PD-L1 checkpoint inhibitor, at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) 37th Annual Meeting, held November 8-12, 2022, in Boston, MA (Press release, ChemoCentryx, OCT 5, 2022, View Source [SID1234621736]).

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ChemoCentryx Poster Presentations at SITC (Free SITC Whitepaper) 37th Annual Meeting (November 8-12, 2022):

Results From an Ongoing Open-Label, Multicenter, Phase 1 Trial of CCX559, an Orally Administered Small Molecule PD-L1 Inhibitor, in Patients with Advanced Solid Tumors

Abstract Number: 769
Location: Hall C
Presentation Time: November 10, 2022, 11:40 a.m. – 1:10 p.m. ET
Poster Viewing Time: November 10, 2022, 9:00 a.m. – 9:00 p.m. ET

The Small Molecule PD-L1 Inhibitor CCX559 Preferentially Accumulates in Tumors, Resulting in Depletion of Cell-Surface PD-L1 in a Murine Preclinical Model

Abstract Number: 499
Location: Hall C
Presentation Time: November 10, 2022, 11:40 a.m. – 1:10 p.m. ET
Poster Viewing Time: November 10, 2022, 9:00 a.m. – 9:00 p.m. ET

About CCX559

CCX559 is a highly potent orally administered small molecule PD-L1 checkpoint inhibitor. Preclinical characterization has demonstrated that CCX559 blocks binding to PD-1 and CD80, and prevents PD-L1 inhibition of T cell activation. CCX559, when orally administered in animal models, demonstrated anti-tumor efficacy, including the ability to induce complete responses.

The PD-L1/PD-1 interaction is one of the major immune checkpoints that limits the ability of effector T cells to destroy cancer cells. As a potential next generation therapy, an orally administered small molecule inhibitor of PD-L1 could have advantageous properties compared to approved monoclonal antibodies, such as better penetration into solid tumors, reduced immunogenicity, lack of Fc-mediated side effects and convenience of oral administration.

During 2021, ChemoCentryx initiated a first-in-human Phase I dose escalation study to evaluate the safety, tolerability, PK, and PD of CCX559 in patients with various types of advanced cancer. In early 2023, the Company plans to advance CCX559 into a Phase Ib/II clinical trial to measure anti-tumor effects of CCX559 more directly.

On October 5, 2022 Fortress Biotech, Inc. (Common Stock: Nasdaq: FBIO) (Preferred Stock: Nasdaq: FBIOP) ("Fortress"), an innovative biopharmaceutical company focused on efficiently acquiring, developing and commercializing or monetizing promising therapeutic products and product candidates, reported its board of directors has declared the regular monthly dividend of $0.1953125 per share of the Company’s 9.375% Series A Cumulative Redeemable Perpetual Preferred Stock (the "Series A Preferred Stock") for the months of October, November and December 2022 (Press release, Fortress Biotech, OCT 5, 2022, View Source [SID1234621735]). The dividend will be payable on the last day of each month (October 31, November 30, and December 31) to holders of record as of the close of business on the fifteenth of that same month (October 15, November 15, December 15). Dividends will be paid in cash.

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Going forward, future notifications related to dividends for the Series A Preferred Stock will be disclosed on the Fortress website in the Investors section on the FBIOP Announcements page under Resources, View Source In addition, investors will also be able to find Form 8937s related to FBIOP on the same page.

On October 5, 2022 Poseida Therapeutics, Inc. (Nasdaq: PSTX), a clinical-stage biopharmaceutical company utilizing proprietary genetic engineering platform technologies to create cell and gene therapeutics with the capacity to cure, reported that it will present a Trial in Progress poster at the upcoming Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) Annual Meeting, being held in Boston and virtually from November 8 –12, 2022 (Press release, Poseida Therapeutics, OCT 5, 2022, View Source [SID1234621734]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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The poster presentation will highlight the trial design, dosing regimen, and study protocol for the Company’s ongoing Phase 1 clinical trial of P-MUC1C-ALLO1. The multi-center, open-label, dose escalation study is evaluating patients with locally advanced or metastatic epithelial derived solid tumors that are refractory to standard of care therapy or ineligible or refused another existing treatment. The study is following a 3+3 design and is evaluating the safety, tolerability, and preliminary efficacy of P-MUC1C-ALLO1. The Company expects to report initial clinical data from this trial by the end of 2022 or early 2023.

Details of the presentation are as follows:

Title: Phase 1 study of P-MUC1C-ALLO1 allogeneic CAR-T cells in patients with epithelial-derived cancers
Presenter: Jason Henry, MD, Sarah Canon Research Institute
Session Date and Time: Poster Hall opens Friday, November 11, 2022, 9:00 AM – 8:30 PM ET
Abstract Number: 728
Location: Boston Convention & Exhibition Center, Hall C

The poster will also be available to meeting attendees through the virtual poster hall on the SITC (Free SITC Whitepaper) virtual meeting platform.

About P-MUC1C-ALLO1
P-MUC1C-ALLO1 is an allogeneic CAR-T product candidate in Phase 1 development for multiple solid tumor indications. Poseida believes P-MUC1C-ALLO1 has the potential to treat a wide range of solid tumors derived from epithelial cells, such as breast, colorectal, lung, ovarian, pancreatic and renal carcinomas, as well as other cancers expressing a cancer-specific form of the Mucin 1 protein, or MUC1-C. P-MUC1C-ALLO1 is designed to be fully allogeneic, with genetic edits to eliminate or reduce both host-vs-graft and graft-vs-host alloreactivity. Poseida has demonstrated the elimination of tumor cells to undetectable levels in preclinical models of both triple-negative breast and ovarian cancer.

On October 5, 2022 Leap Therapeutics, Inc. (Nasdaq: LPTX), a biotechnology company focused on developing targeted and immuno-oncology therapeutics, reported the Company will be presenting updated data from Part B of the DisTinGuish Study evaluating DKN-01 in combination with tislelizumab, BeiGene’s anti-PD-1 antibody, in second-line gastroesophageal junction/gastric (GEJ/G) cancer patients whose tumors express high levels of DKK1 (DKK1-high) at the Society of Immunotherapy for Cancer (SITC) (Free SITC Whitepaper) 37th Annual Meeting being held in Boston, MA on November 8-12, 2022 (Press release, Leap Therapeutics, OCT 5, 2022, View Source [SID1234621733]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Leap will also present preclinical DKN-01 data supporting the DeFianCe Study, a Phase 2 study of DKN-01 in combination with bevacizumab and standard of care chemotherapy in patients with advanced colorectal cancer who have received one prior systemic therapy.