On October 07, 2022 InnovoTEX, an Austin-based pharmaceutical company, reported that the company is developing next generation anti-cancer agents that localize to solid tumors and overcome resistance mechanisms with minimal side effects, to overcome the limited efficacy in drug-sensitive and drug-resistant solid tumors of the traditional chemotherapies (Press release, InnovoTEX, OCT 7, 2022, View Source [SID1234637954]).
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InnovoTEX is developing its proprietary TEX Core platform, which utilizes the tumor-localizing and well-tolerated small molecule, texaphyrin, as the basis for a series of conjugates designed to target and treat both drug-sensitive and drug-resistant solid tumors.
The first clinical candidate to be commercialized from the platform is OxaliTEX, a novel chemical entity (WO2015/191797) in a pro-drug form. Patent applications covering both composition and methods of treatment claims for OxaliTEX have been filed in 15 global jurisdictions. Currently, OxaliTEX patents covering the core compositions have been issued in the United States, Australia, Israel, South Korea, Mexico and Singapore.
Pre-clinical research conducted at the University of Texas at Austin and MD Anderson Cancer Center has demonstrated oncolytic activity in multiple indications. OxaliTEX was found to completely inhibit the tumor growth in platinum-resistant patient derived xenografts and result in extended survival of ovarian and colon cancer models. Platinum-resistant ovarian cancer is the planned lead indication for OxaliTEX.
"From the preclinical data generated, OxaliTEX has displayed greater efficacy and tolerability against advanced human cancer models compared to traditional chemotherapies. We are optimistic that OxaliTEX’s therapeutic benefits will translate well to the clinic with further development," InnovoTEX CEO, Dr. Jonathan Arambula said.
Professor Jonathan Sessler, R.P. Doherty, Jr. – Welch Regents Chair in Chemistry at the University of Texas at Austin, partnered with Dr. Arambula and Dr. Zahid Siddik at MD Anderson Cancer Center, in developing technologies that led to OxaliTEX.
"I am excited to see this technology moving to the next level of development and advancing to the clinic for the treatment of a disease for which our current therapeutic options are still unsatisfactory," Professor Sessler said.
Research was generously funded by multiple institutions, including the Cancer Prevention and Research Institute of Texas, the National Institutes of Health and the Robert A. Welch Foundation.