Theralase ® Closes $2.5M Private Placement Equity Financing 

On September 22, 2022 Theralase Technologies Inc. ("Theralase" or the "Company") (TSXV: TLT) (OTCQB: TLTFF), a clinical stage pharmaceutical company focused on the research and development of light activated Photo Dynamic Compounds ("PDCs") and their associated drug formulations, used to destroy various cancers, bacteria and viruses, safely and effectively, reported that it has closed a non-brokered private placement offering ("Offering") of units ("Units") (Press release, Theralase, SEP 22, 2022, View Source [SID1234621543]). On closing, the Corporation issued an aggregate of 10,000,000 Units at a price of $0.25 per Unit for aggregate gross proceeds of approximately $2,500,000.

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Each Unit consisted of one common share of the Company ("Common Share") and one common share purchase warrant ("Warrant"). Each Warrant entitles the holder to acquire an additional Common Share at an exercise price of $0.35 per share for a period of 24 months following the date of issuance.

In connection with the Offering, the Company paid a finder’s fee of $10,167 in cash and 76,800 in Common Shares at a price of $0.25 per Common Share and issued 58,734 finder’s warrants. Each finder’s warrant is exercisable into one Common Share at an exercise price of $0.35 per share for a period of 24 months after the closing of the Offering.

The Company intends to use the proceeds of the Offering for the following:

Good Laboratory Practice ("GLP") Toxicology Study for Intravenous installation of Rutherrin intended for the treatment of Non Small Lung Cancer ("NSCLC") and Glio Blastoma Multiforme ("GBM")
Advancement of Phase II Non-Muscle Invasive Bladder Cancer ("NMIBC") clinical study
Working capital and general corporate purposes
The securities referred to in this news release have not been, and will not be, registered under the United States Securities Act of 1933, as amended (the "U.S. Securities Act"), or any applicable securities laws of any state of the United States, and may not be offered or sold within the United States or to, or for the account or benefit of, U.S. persons (as such term is defined in Regulation S under the U.S. Securities Act) or persons in the United States unless registered under the U.S. Securities Act and any other applicable securities laws of the United States or an exemption from such registration requirement is available. This press release shall not constitute an offer to sell or a solicitation of an offer to buy nor shall there be any sale of the securities offered in any jurisdiction in which such offer, solicitation or sale would be unlawful, including the United States.

All securities issued under the Offering will be subject to a four month and one day hold period from the closing date under applicable Canadian securities laws, which expires on January 22, 2023. The Offering is subject to receipt of final acceptance from the TSX Venture Exchange.

Related Party Transactions
An aggregate of 2,400,000 Units, representing gross proceeds of $600,000, were issued to certain insiders of the Corporation. Pursuant to Multilateral Instrument 61-101 – Protection of Minority Security Holders in Special Transactions ("MI 61-101") and TSX Venture Exchange Policy 5.9, such insider subscriptions are a "related party transaction." The Corporation is exempt from the formal valuation requirement of MI 61-101 in connection with the insider subscriptions in reliance on section 5.5(b) of MI 61-101, as no securities of the Corporation are listed or quoted for trading on the Toronto Stock Exchange, the New York Stock Exchange, the American Stock Exchange, the NASDAQ stock market or any other stock exchange outside of Canada and the United States. Additionally, the Corporation is exempt from obtaining minority shareholder approval in connection with the insider subscriptions in reliance on section 5.7(1)(a) of MI 61-101 as the aggregate value of the insider subscriptions does not exceed 25% of the market capitalization of the Corporation. Due to the limited time between the launch and the close of the Offering, there will be less than 21 days between the date the Corporation files its material change report in respect of the Offering and the completion date of the Offering.

EDAP Announces Pricing of Public Offering of American Depositary Shares

On September 22, 2022 EDAP TMS S.A. (NASDAQ: EDAP) (the "Company"), a global leader in robotic energy-based therapies, reported that the price of its public offering of its American Depositary Shares ("ADSs"), which commenced on September 22, 2022, has been set today at $7.50 per ADS, before underwriting discounts and commissions, and that the number of offered ADSs is 2,666,667 (Press release, EDAP TMS, SEP 22, 2022, View Source(NASDAQ%3A%20EDAP)%20(the,and%20that%20the%20number%20of [SID1234621392]). In addition, Jefferies LLC has been granted a 30-day over-allotment option to purchase up to an additional 400,000 ADSs on the same terms and conditions. The gross proceeds from the offering, before deducting underwriting discounts and commissions and other offering expenses payable by the Company, are expected to be approximately $20,000,003. The closing of the offering is expected to occur on September 27, 2022, subject to customary closing conditions.

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Jefferies LLC is acting as the sole book-running manager for the offering.

A shelf registration statement on Form F-3 (including a prospectus) relating to the Company’s American Depositary Shares was filed with the Securities and Exchange Commission (the "SEC") on April 7, 2021 and is effective. The Company has also filed a base prospectus dated April 16, 2021 and a preliminary prospectus supplement dated September 22, 2022 with respect to the offering. A final prospectus supplement and the accompanying prospectus will be filed with the SEC. You may obtain these documents for free by visiting EDGAR on the SEC’s website at www.sec.gov. Alternatively, when available, a copy of the prospectus supplement (and accompanying prospectus) relating to the offering may be obtained from Jefferies LLC, Attn: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, New York 10022, by telephone at +1 (877) 821-7388 or by email at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction. In particular, no public offering of the ADSs will be made in Europe.

Mirati Therapeutics to Participate in Two Upcoming Healthcare Conferences

On September 22, 2022 Mirati Therapeutics, Inc. (NASDAQ: MRTX), a clinical-stage targeted oncology company, reported that it will participate in two upcoming healthcare conferences (Press release, Mirati, SEP 22, 2022, View Source [SID1234621391]).

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Thursday, September 29 at 10:00 a.m. ET / 7:00 a.m. PT at the Guggenheim Nantucket Therapeutics Conference. David Meek, chief executive officer, will represent the company in a fireside chat.
Monday, October 3 at 1:10 p.m. ET / 10:10 a.m. PT at the Bank of America Precision Oncology Conference. David Meek, chief executive officer, will represent the company in a fireside chat.
Investors and the general public are invited to listen to a live webcast of the sessions through the "Investors and Media" section on Mirati.com. A replay of the webcast will be made available following the event.

NeuBase to Participate at Chardan’s 6th Annual Genetic Medicines Conference

On September 22, 2022 NeuBase Therapeutics, Inc. (Nasdaq: NBSE) ("NeuBase" or the "Company"), a biotechnology platform company Drugging the Genome to address disease at the base level using a new class of precision genetic medicines, reported that company management will participate in-person for a fireside chat at Chardan’s 6th Annual Genetic Medicines Conference being held in New York City on October 3-4, 2022 (Press release, NeuBase Therapeutics, SEP 22, 2022, View Source [SID1234621375]).

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An audio replay of the webcast will be available following the presentation for 90 days. To access the replay, please click here. Please contact your representative at Chardan to schedule a one-on-one meeting with NeuBase management during the conference.

Aprea Therapeutics Announces Poster Presentation at the 2022 Rivkin Center and American Association for Cancer (AACR) Virtual Ovarian Cancer Research Seminar Series

On September 22, 2022 Aprea Therapeutics, Inc. (Nasdaq: APRE), a biopharmaceutical company focused on developing novel synthetic lethality-based cancer therapeutics targeting DNA damage response (DDR) pathways, reported that the abstract titled "ATRN-W1051, a novel and potent WEE1 inhibitor for the treatment of CCNE1-overexpressing ovarian cancer" will be presented at the 14th Biennial Virtual Ovarian Cancer Research Seminar Series presented by the Rivkin Center and the American Association for Cancer Research (AACR) (Free AACR Whitepaper) (Press release, Aprea, SEP 22, 2022, View Source [SID1234621374]). The series will take place on September 21, 22, 28, and 29, 2022, with each day scheduled to run from 12:00-2:00pm U.S. Pacific Time.

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"A growing body of scientific evidence provides exciting development opportunities for our WEE1 inhibitor, ATRN-W1051," said Oren Gilad, Ph.D., President and Chief Executive Officer of Aprea. "ATRN-W1051 is designed to be a potent and selective WEE1 inhibitor with a differentiated structure and potentially preferable pharmacokinetic properties. The presented data demonstrate anti-proliferative activity against a variety of cancer cell lines and tumor growth inhibition in a genetically-defined ovarian cancer xenograft model. We look forward to completing the IND-enabling studies and plan to initiate the clinical program shortly thereafter."

A copy of the poster will be accessible from the "Events Calendar" in the News and Events section of the Aprea website.