On September 23, 2022 Tiziana Life Sciences Ltd. (Nasdaq: TLSA) ("Tiziana" or the "Company"), a biotechnology company enabling breakthrough immunotherapies via novel routes of drug delivery, reported that it has been notified that Matthew Davis, its Chief Medical Officer, purchased 75,000 common shares at $0.83 per share, bringing his total holding to 175,000 common shares (Press release, Tiziana Life Sciences, SEP 23, 2022, View Source [SID1234621388]).

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On September 23, 2022 TechnoPhage reported the spin-off of T-Oncology AG, which will focus on the development of Antibody Drug Conjugates (ADCs), based on the proprietary Small Domain Antibodies platform (TechnoBodies), for the treatment of cancer (Press release, TechnoPhage, SEP 23, 2022, View Source;utm_medium=rss&utm_campaign=technophage-s-a-announces-spin-off-of-t-oncology-ag [SID1234621387]).

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TechnoBodies technology has been developed at TechnoPhage and, taking advantage of the small size of the fragment antibodies obtained, T-Oncology will construct and scale ADCs for targeted novel cancer therapy. Overall, this technology enables the sensitive discrimination between healthy and cancerous tissues and will be ultimately applied in unmet medical needs in the field of oncology.

It is also now clear to TechnoPhage’s management team that pursuing a spin-off is the most compelling path forward; indeed, "creating a new company specialized in a single technology and a specialized clinical indication can create significant value for our patients, partners and clients" said Miguel Garcia, CEO of TechnoPhage.

The new company incorporated in Kanton Zug, Switzerland, is expected to also set base as a resident in the Johnson & Johnson Life Science Incubators and Accelerators, at JLABS in Beerse, Belgium and start recruiting a new team in the next year.

On September 23, 2022 Oncternal Therapeutics, Inc. (Nasdaq: ONCT), a clinical-stage biopharmaceutical company focused on the development of novel oncology therapies, reported that management will participate in the Cantor Oncology, Hematology & HemeOnc Conference on Wednesday, September 28, 2022 at the NY Palace Hotel in New York City (Press release, Oncternal Therapeutics, SEP 23, 2022, View Source [SID1234621386]).

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James Breitmeyer, M.D, Ph.D., Oncternal’s President and Chief Executive Officer, will participate in person in the "Multiple Myeloma & Lymphoma" panel at 4:15pm (ET) at the Hubbard Room I, and the Company will host one-on-one meetings.

On September 23, 2022 Moleculin Biotech, Inc., (Nasdaq: MBRX) (Moleculin or the Company), a clinical stage pharmaceutical company with a broad portfolio of drug candidates targeting highly resistant tumors and viruses, reported that Walter V. Kemp, Founder, President, CEO and Chairman, and Wolfram C. M. Dempke, MD, PhD, MBA, European Chief Medical Officer of Moleculin will participate in the Virtual Investor Innovations in Acute Myeloid Leukemia Spotlight Event on Wednesday, September 28, 2022 at 11:00 AM ET (Press release, Moleculin, SEP 23, 2022, View Source [SID1234621385]).

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As part of the virtual event, the Company will discuss it’s next-generation anthracycline, Annamycin, and its ongoing clinical development for the treatment of AML for people who are refractory to or relapsed after induction therapy. The ongoing Phase 1/2 trial (MB-106) evaluating Annamycin in combination with Cytarabine (also known as "Ara-C" and for which the combination of Annamycin and Ara-C is referred to as AnnAraC) is an open label trial that builds on the safety and dosage data from two successfully concluded single agent Annamycin AML Phase 1 trials (MB-104 and MB-105) in the U.S. and Europe, respectively, and the preclinical data from the Company’s sponsored research studies.

In addition to the moderated portion of the event, investors and interested parties will have the opportunity to submit questions. The Company will answer as many questions as possible during the event.

A live video webcast of the Event will be available on the Events page of the Investors section of the Company’s website (moleculin.com). A webcast replay will be available two hours following the live presentation and will be accessible for one year.

On September 23, 2022 Immutep Limited (ASX: IMM; NASDAQ: IMMP) ("Immutep" or "the Company"), a biotechnology company developing novel LAG-3 related immunotherapy treatments for cancer and autoimmune diseases, reported it has received a €1,804,341 (~ A$2,693,046 ) research and development (R&D) tax incentive payment in cash from the French Government under its Crédit d’Impôt Recherche scheme (CIR) (Press release, Immutep, SEP 23, 2022, View Source [SID1234621384]).

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The "Crédit d’Impôt Recherche" (CIR), meaning "Research Tax Credit", is a French government tax incentive by which French companies conducting research and development activities in Europe can be reimbursed 30% of their eligible expenditure.

Immutep qualifies to receive the CIR tax incentive through its subsidiary Immutep S.A.S. due to the research and development conducted in its laboratory in France. The cash payment is provided in respect of expenditure incurred on eligible R&D activities conducted in the European Union in the 2021 calendar year. Immutep also qualifies for cash rebates from the Australian Federal Government’s R&D tax incentive program in respect of expenditure incurred on eligible R&D activities conducted in Australia.

The funds will be used to support the ongoing and planned global clinical development of eftilagimod alpha and the preclinical development of IMP761.