Guardant Health Applauds Congressional Letter Calling for HHS Action to Improve USPSTF Process to Increase Access to Cancer Screenings

On July 25, 2022 Guardant Health, a leading precision oncology company, reported that applauds Congresswoman Anna Eshoo (D-CA) and Energy and Commerce Chairman Frank Pallone (D-NJ) for raising important questions in a letter to U.S. Health and Human Services (HHS) Secretary Xavier Becerra on how the United States Preventive Services Task Force (USPSTF) process can be improved to increase patient access to essential preventive services such as early cancer screening tests (Press release, Guardant Health, JUL 25, 2022, View Source [SID1234616903]).

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The USPSTF is an independent, volunteer advisory board that issues evidence-based recommendations on which clinical preventative services Americans should receive.1 Services that receive an "A" or "B" grade from the Task Force are covered with $0 cost-sharing for insured patients.2 Under its current structure, the USPSTF aims to review and update existing recommendations every five years, though multi-year delays are common.3,4

"The Task Force guidelines play a key role in ensuring people have access to preventative services like early cancer screening however, the current USPSTF five-year update cycle doesn’t reflect today’s pace of innovation," said AmirAli Talasaz, Guardant Health co-CEO. "We thank Reps. Eshoo and Pallone for their action, and hope that HHS leadership will take the necessary steps to improve the USPSFT process so that innovative technologies like blood-based cancer screening tests can be accessible to patients upon FDA approval."

The Congressional letter outlines how a new blood test to screen asymptomatic, average-risk patients for colorectal cancer (CRC) may not be accessible to patients right away under the current USPSTF process. The most recent USPSTF review of CRC screening was completed in May 20215 and the next recommendation is not expected until 2026. Therefore, should FDA approval be granted for CRC blood-based screening tests, it may still be years until the USPSTF releases its next recommendation to include blood tests.

The inability to provide access to the latest innovations in cancer screening technology has far-reaching implications. More than 75% of people who die from CRC today are not up to date with recommended screening.6 Blood tests have the potential to overcome many of the access barriers associated with current CRC screening methods by incorporating these tests into routine medical care. Timely access to innovative new cancer screening technologies like blood tests can lead to improved compliance, early detection and diagnosis.

For more information on how Guardant Health is advocating for access to modern cancer screenings visit View Source

Transactions in connection with share buy-back program

On July 25, 2022 Genmab A/S reported the initiation of a share buy-back program to mitigate dilution from warrant exercises and to honor our commitments under our Restricted Stock Units program (Press release, Genmab, JUL 25, 2022, View Source [SID1234616902]).

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The share buy-back program is expected to be completed no later than August 31, 2022 and comprises up to 370,000 shares.

The following transactions were executed under the program from July 18, 2022 to July 22, 2022:

Details of each transaction are included as an appendix to this announcement.

Following these transactions, Genmab holds 417,583 shares as treasury shares, corresponding to 0.63% of the total share capital and voting rights.

The share buy-back program is undertaken in accordance with Regulation (EU) No. 596/2014 (‘MAR’) and the Commission Delegated Regulation (EU) 2016/1052, also referred to as the "Safe Harbour Regulation." Further details on the terms of the share buy-back program can be found in our company announcement no. 22 dated June 17, 2022.

FibroGen to Report Second Quarter 2022 Financial Results

On July 25, 2022 FibroGen, Inc. (NASDAQ: FGEN) reported that it will announce its second quarter 2022 financial results on Monday, August 8 after the market close. FibroGen will also conduct a conference call on that day at 5:00 p.m. ET (2:00 p.m. PT) with the investment community to further detail the company’s corporate and financial performance (Press release, FibroGen, JUL 25, 2022, View Source [SID1234616901]).

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Conference Call and Audio Webcast
Interested parties may access a live audio webcast of the conference call via the "Investor Relations" page of the Company’s website at www.fibrogen.com. To access the call by phone, please go to this link (registration link), and you will be provided with dial in details. To avoid delays, we encourage participants to dial into the conference call fifteen minutes ahead of the scheduled start time. A replay of the webcast will also be available for a limited time at the following link (webcast replay).

Fate Therapeutics to Webcast Conference Call Reporting Second Quarter 2022 Financial Results

On July 25, 2022 Fate Therapeutics, Inc. (the "Company" or "Fate Therapeutics") (NASDAQ: FATE), a clinical-stage biopharmaceutical company dedicated to the development of programmed cellular immunotherapies for patients with cancer, reported that the Company will host a conference call and live audio webcast on Wednesday, August 3, 2022 at 5:00 PM ET to report its second quarter 2022 financial results and provide a corporate update (Press release, Fate Therapeutics, JUL 25, 2022, https://ir.fatetherapeutics.com/news-releases/news-release-details/fate-therapeutics-webcast-conference-call-reporting-second-7 [SID1234616900]).

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In order to participate in the conference call, please dial (877) 545-0320 (domestic) or (973) 528-0002 (international) and refer to conference ID 687045. The live webcast can be accessed under "Events & Presentations" in the Investors section of the Company’s website at www.fatetherapeutics.com. The archived webcast will be available on the Company’s website beginning approximately two hours after the event.

Rona Therapeutics Announces Exclusive Licensing Transaction from Sanofi for its Broad siRNA Therapeutic Portfolio and Technology Platform

On July 25, 2022 Rona Therapeutics, Inc ("Rona"), a fully integrated platform company dedicated to the discovery, development and manufacturing of RNA therapeutics, reported that it has obtained worldwide exclusive rights to Sanofi’s siRNA platform of chemical modification and delivery moiety as well as rights to four pre-clinical candidates for undisclosed targets (Press release, Sanofi, JUL 25, 2022, View Source [SID1234616899]). These rights will enable Rona to significantly expand and accelerate Rona’s siRNA portfolio in both liver and non-liver applications. The technology platform is a strategic fit for Rona in establishing industry-leading oligonucleotide modification, delivery and RNA biology expertise across a rapidly growing pipeline. In addition, Sanofi receives an exclusive option for selected neuro and muscular candidates discovered using the siRNA platform for territories outside of mainland China, Hong Kong, Taiwan and Macao (collectively "Greater China").

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Under the deal, Rona also acquired rights to further develop, manufacture and commercialize candidates from four liver-targeting preclinical programs. Based on novel nucleotide analogs and conjugation moiety, the siRNA platform has demonstrated enhanced stability and in vivo duration of action as well as potential for therapeutic silencing of target genes in various tissue types. "Rona plans to quickly advance the development of these programs in metabolic, neurological and ocular diseases to unlock the potential of siRNA therapeutics," said Stella Shi, Chief Executive Officer of Rona Therapeutics, "We are excited to acquire these rights from Sanofi to bring transformative RNA medicines to patients worldwide".

Under the terms of the agreement, Rona Therapeutics will make an upfront payment to Sanofi, in addition to development and commercial milestones, as well as royalties on net sales of products.