On July 6, 2022 BeiGene (NASDAQ: BGNE; HKEX: 06160; SSE: 688235), a global, science-driven biotechnology company focused on developing innovative and affordable medicines to improve treatment outcomes and access for patients worldwide, reported it entered into a worldwide strategic collaboration with InnoRNA, a biotechnology company with expertise in LNP-based delivery technology and mRNA drug discovery, to leverage its innovative technology platform for developing mRNA-based therapeutics (Press release, BeiGene, JUL 6, 2022, View Source [SID1234616512]).

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"As a global biotechnology company, BeiGene is committed to delivering next-generation therapies through our own internal discovery engine and leveraging cutting-edge technology from experienced and innovative partners"

"As a global biotechnology company, BeiGene is committed to delivering next-generation therapies through our own internal discovery engine and leveraging cutting-edge technology from experienced and innovative partners," said Lai Wang, Ph.D., Global Head of R&D at BeiGene. "This collaboration with InnoRNA advances and supports our research efforts in the important field of mRNA therapies while securing critical, proprietary delivery tools."

Under the terms of the agreement, InnoRNA will receive an upfront cash payment and will be eligible to receive additional payments based upon the achievement of certain development, regulatory, and commercial milestones, as well as tiered royalties, for the mRNA-LNP research collaboration programs. BeiGene will hold exclusive global development and commercialization rights for the mRNA-LNP therapies jointly discovered by InnoRNA and BeiGene.

InnoRNA will receive an additional upfront cash payment and is eligible for additional milestone payments for granting BeiGene non-exclusive license to its proprietary LNP Technology platform.

"We are very excited to partner with BeiGene to discover and develop innovative mRNA therapies as well as contribute our LNP technology to BeiGene’s internal research," said Linxian Li, Ph.D., Founder and Chief Executive Officer of InnoRNA. "As evidenced by the success of multiple Covid-19 vaccines, mRNA and LNPs will likely play a major role in the future of drug development, potentially in broad fields beyond vaccines. Joining this collaboration with BeiGene represents a big step forward toward this vision for our company."

On July 6, 2022 Selecta Biosciences, Inc. (NASDAQ: SELB), a biotechnology company leveraging its clinically validated ImmTOR platform to develop tolerogenic therapies for autoimmune diseases, enhance gene therapies and mitigate unwanted immune responses to biologics, reported that Company’s Management will participate virtually in a fireside chat and in one-on-one investor meetings at the Guggenheim I&I Spotlight Series – Treg-based Therapies Conference, to be held virtually and in-person in New York, NY July 12-13 (Press release, Selecta Biosciences, JUL 6, 2022, View Source [SID1234616511]).

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Guggenheim I&I Spotlight Series – Treg-based Therapies Conference
Format: Fireside chat and one-on-one investor meetings
Date: Wednesday, July 13, 2022
Time: 1:00 p.m. ET
Webcast: Click Here

An archived webcast will also be accessible in the Investors & Media section of the company’s website at www.selectabio.com.

On July 6, 2022 Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) reported that it will report its second quarter 2022 financial and operating results on Wednesday, August 3, 2022, before the U.S. financial markets open (Press release, Regeneron, JUL 6, 2022, View Source [SID1234616510]). The Company will host a conference call and simultaneous webcast at 8:30 AM Eastern Time that day.

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Conference Call Information
Participants may access the conference call live via webcast on the ‘Investors and Media’ page of Regeneron’s website at View Source To participate via telephone, please register in advance at this link. Upon registration, all telephone participants will receive a confirmation email detailing how to join the conference call, including the dial-in number along with a unique passcode and registrant ID that can be used to access the call. A replay of the conference call and webcast will be archived on the Company’s website for at least 30 days.

On July 6, 2022 Dr. Ettore Gilardoni, Head of Bio-MS at Philogen reported that it will present a poster entitled: A mass spectrometry-based method for the determination of in vivo biodistribution of small molecule-metal conjugates (Press release, Philogen, JUL 6, 2022, View Source [SID1234616509]).

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Dr. Gilardoni will also give a presentation on August 31st, entitled: Fibrioblast activation protein triggers selective release of drug payload from small molecule-drug conjugates in solid tumors.

On July 6, 2022 Gnubiotics Sciences, a biotech company pioneering the discovery and development of immunomodulatory glycopeptides, reported that the Swiss Innovation Agency (Innosuisse) will support a research collaboration with the University Hospital Zürich to accelerate the development of Gnubiotics’ GLAAD technology in a range of solid tumors (Press release, Gnubiotics Sciences, JUL 6, 2022, View Source [SID1234616507]). The total project cost of CHF 1.4 million (USD 1.4 million) will be supported by the grant from Innosuisse as well contributions from Gnubiotics.

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Altered glycosylation of tumors is a signature of cancer development, making glycans an emerging target especially in immunotherapy resistant patient cohorts. The sponsored project will advance GNU201 and GNU101, as potential first-in-class immunotherapeutics that steer immune responses to control growth in solid tumors expressing altered O-glycan profiles thus responding to a critical need in non-responding patients. The multi-year project which will include dose-finding and key translational studies, forms a core part of a broader preclinical development plan that will support an Investigational New Drug Application (IND).

"This support from Innosuisse and continued close collaboration with Prof. Michael Scharl`s group at the University Hospital Zürich provide further validation of our GLAAD platform, which holds great therapeutic potential for anti-PD-1 resistant and other non-responsive patient cohorts." stated Yemi Adesokan, Ph.D., Gnubiotics’s Chief Executive Officer.

Gnubiotics presented compelling data recently at the 2022 American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) annual meeting showing the effect of its glycopeptides platform in driving robust T-cell immune responses against anti-PD-1 resistant tumors in a colorectal cancer mouse model. Also announced recently, was a collaboration with the University of Pennsylvania to explore CAR-T therapy in combination with Gnubiotics’ glycopeptides to enhance CAR-T efficacy in solid tumors.