Wugen to Participate in Upcoming June Investor Conferences

On June 1, 2022 Wugen, Inc., a clinical-stage biotechnology company developing a pipeline of off-the-shelf cell therapies to treat a broad range of hematological and solid tumor malignancies, reported that management will participate in two upcoming investor conferences in June (Press release, Wugen, JUN 1, 2022, View Source [SID1234615351]):

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Jefferies Healthcare Conference
Format: Presentation
Presentation Date/Time: Wednesday, June 8, 2022 at 4:30 p.m. ET
Location: New York City

2022 Truist Securities Symposia
Format: Panel titled "Novel Engineered NK Cell Therapies: Pursuit of The Right Phenotype"
Presentation Date/Time: Tuesday, June 28, 2022 at 11:00 a.m. ET
Location: New York City

Scandion Oncology resolves on a Rights Issue of approximately SEK 93.7 million

On June 1, 2022 The Board of Directors of Scandion Oncology ("Scandion"), a biotech company developing first-in-class medicines aimed at treating cancer which is resistant to current treatment options, has, based on the authorization granted by the Extraordinary General Meeting (EGM) on 13 November 2020, reported that resolved on an issue of shares with preferential rights for existing shareholders ("Rights Issue") (Press release, Scandion Oncology, JUN 1, 2022, View Source,c3578213 [SID1234615350]).

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In the event of full subscription, the Rights Issue will provide Scandion with approximately SEK 93.7 million before deduction of issue costs. The Rights Issue is covered by subscription and guarantee commitments from principal owners and new investors corresponding to approximately 80% of the issue proceeds.

Scandion will use the proceeds from the Rights Issue to approximately double the commercial potential of its lead asset, SCO-101, in metastatic colorectal cancer (mCRC) by expanding the clinical development in this indication to also explore RAS mutated patients.

Additionally, proceeds will be used to conduct pre-clinical development to explore and position the use of SCO-101 and other candidates in combination with e.g. immunotherapy and chemotherapy, and to finance the overall development of Scandion as a listed clinical stage biotech company and attractive investment case also for institutional investors. This includes up-listing to the Nasdaq main market.

"We are delighted to being able to raise additional capital to fund our long-term planning and execution of our strategy. In this way we can create the most value from our compounds, first and foremost by approximately doubling the commercial potential for SCO-101. This will be a very important element in our long-term value creation", says Bo Rode Hansen, President & CEO of Scandion.

The Rights Issue in brief
The Board of Directors has, based on the authorization granted by the EGM on 13 November 2020, resolved on an issue of shares with preferential rights for existing shareholders. It will also be possible to subscribe for shares without preferential rights.

In the event all shares are not subscribed for with subscription rights, the board of directors shall resolve on the allotment of shares subscribed for without subscription rights. In such case shares shall firstly be allotted to persons who have also subscribed for shares by exercising subscription rights, secondly to other persons who have subscribed for shares without exercising subscription rights, and thirdly to guarantors.

Issue size: In the event of full subscription, Scandion will receive approximately SEK 93.7 million before deduction of transaction related costs. Preliminary transaction related costs are approximately SEK 17 million.
Record date: Holders of Scandion shares on the record date of 13 June 2022 are entitled to subscribe for shares in the Rights Issue in relation to their holding of shares on the record date. Last day for trading including the right to subscribe for shares is 9 June 2022. The first day of trading excluding the right to subscribe shares is 10 June 2022.
Preferential rights: For one (1) existing share on the record date of 13 June 2022, shareholders will receive one (1) subscription right. Three (3) subscription rights entitle to subscription of one (1) share.
Subscription price: SEK 8.75 per share. No commission is payable.
Subscription and guarantee commitments: Subscription and guarantee commitments have been received from principal owners and new investors amounting to approximately SEK 75 million, corresponding to approximately 80% of the issue proceeds.
Terms of the Rights Issue

Those who are registered as shareholders on the record date, 13 June 2022, have the preferential right to subscribe for new shares in the Rights Issue in relation to the number of shares held on the record date. One (1) existing share in Scandion entitles to one (1) subscription right. Three (3) subscription rights entitle to subscription of one (1) new share, i.e., a subscription ratio of 1:3. In addition, investors are offered the possibility to subscribe for shares without subscription rights.

In the event that all shares are not subscribed for with subscription rights before the expiry of the subscription period, the remaining shares will, without compensation to the holders of unexercised subscription rights, be allotted to such existing shareholders and qualified investors having made binding undertakings to subscribe for remaining shares without subscription rights. In case of oversubscription of the remaining shares, the remaining shares will be allocated according to apportionment keys determined by the board of directors.

The subscription price is SEK 8.75 per new share. Provided that the Rights Issue is fully subscribed, the share capital will increase by a maximum of DKK 787,320.8280 by a new issue of a maximum of 10,711,848 new shares. In the event of full subscription, the Rights Issue will provide Scandion with approximately SEK 93.7 million before deduction of issue costs. Shareholders who choose not to participate in the Rights Issue will, provided that the Rights Issue is fully subscribed, have their ownership diluted by approximately 25%, but have the opportunity to financially compensate for this dilution by selling their subscription rights.

Subscription of shares shall take place during the period from and including 16 June 2022 to and including 1 July 2022. The board of directors has the right to extend the subscription and payment period. A possible extension of the subscription period shall be announced by press release no later than the last subscription day in the Rights Issue, i.e. 1 July 2022. Trading in subscription rights takes place on Nasdaq First North Growth Market during the period from and including 16 June 2022 to and including 28 June 2022 and trading in paid subscribed shares (Sw. Betalda tecknade aktier) during the period from and including 16 June 2022 until the Rights Issue has been registered with the Danish Business Authority (Dk. Erhvervsstyrelsen).

The subscription period and the Rights Issue is conditional on the Danish Financial Supervisory Authority having approved the prospectus and the prospectus having been passported to Sweden prior to the first day of the subscription period.

Subscription and guarantee commitments

Scandion has received subscription and guarantee commitments from principal investors and a guarantee consortium totaling approximately SEK 75 million, corresponding to approximately 80% of the Rights Issue.

Preliminary time plan

9 June 2022 Last day of trading incl. preferential rights
10 June 2022 First day of trading excl. preferential rights
13 June 2022 Record date
15 June 2022 The prospectus is made public
16 June – 28 June 2022 Trading in subscription rights
16 June – 1 July 2022 Subscription period
16 June – until registration with the Danish Business Authority Trading in paid subscription shares (Sw. "BTA")
5 July 2022 Announcement of outcome in the Rights Issue
Lock-up agreements

In connection with the Rights Issue, Scandion’s board members and executive management who own shares in Scandion, have undertaken, subject to customary exceptions, towards Redeye AB, not to transfer or otherwise sell their shares for a period of 180 days after the end of the subscription period.

Investor meetings

Invitation to investor meetings will be sent out separately and will also be presented on Scandion’s and Redeye AB’s respective websites (www.scandiononcology.com, www.redeye.se).

Prospectus

The prospectus is expected to be made public around 15 June 2022. Full terms and conditions as well as information about subscription and guarantee commitments will be available in Scandion’s prospectus which, together with an information folder, will be published on Scandion’s and Redeye AB’s respective websites (www.scandiononcology.com, www.redeye.se).

Advisers
Redeye AB acts as financial adviser and Horten Advokatpartnerselskab (as to Danish law) and Advokatfirman Schjødt (as to Swedish law) act as legal advisers in connection with the Rights Issue. Hagberg & Aneborn Fondkommission AB acts as the issuing agent in the Rights Issue.

Certified Adviser

This information is such information as Scandion is obliged to make public pursuant to the EU Market Abuse Regulation. The information was submitted for publication, through the agency of the contact person set out above, at 13:00 CET on 1 June 2022.

Genomic Testing Cooperative to Reveal “Liquid Trace™” at ASCO, a Liquid Biopsy Test that Combines Cell-Free DNA with Targeted Transcriptome and to Present Data on its Advanced AI for the Diagnosis of Hematologic and Solid Tumors

On June 1, 2022 Genomic Testing Cooperative, LCA (GTC) reported that it will be presenting at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) 2022 annual meeting data showcasing its new innovative approach to liquid biopsy testing that combines both cell-free-DNA (cfDNA) with cell-free RNA (cfRNA), Liquid Trace (Press release, Genomic Testing Cooperative, JUN 1, 2022, View Source [SID1234615349]). Liquid Trace tests both cfDNA and cfRNA not only improves sensitivity of the liquid biopsy but also provides transcriptome data that is enriched by various tumor markers (CA125, CA 15-3, CEA, etc) and makes it possible to perform liquid immunoprofiling by evaluating levels of CD19, CD20, CD33, CD4, CD8, etc.

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This data will be presented in two posters:

– "Combining cell-free RNA (cfRNA) with cell-free total nucleic acid (cfTNA) as a new paradigm for liquid biopsy." Abstract # 3048; Poster # 40, Sunday, June 5, 2022, 8:00 AM-11:00 AM CDT

– "Cell-free RNA in liquid biopsy and biomarkers profiling of hematologic and solid tumors."

Abstract # 3047, Poster # 39, Sunday, June 5, 2022, 8:00 AM-11:00 AM CDT

GTC will also present validation data of its innovative artificial Intelligence (AI) approach that uses targeted transcriptome to classify and aid in the differential diagnosis between 47 different diagnoses of hematologic and solid tumors. This AI is particularly powerful in the differential diagnosis between various types of lymphoma and Hodgkin disease and solid tumors of unknown origin. This data will be presented in the following poster:

– "Differential diagnosis of hematologic and solid tumors using targeted transcriptome and artificial intelligence." Abstract # 3018; Poster # 10; Sunday, June 5, 2022, 8:00 AM-11:00 AM CDT; 4:30 PM-6:00 PM (Discussion)

"Our new Liquid Trace test represents a significant leap in the science of liquid biopsy. Cells in various tissues contain the same DNA, but RNA makes the difference between skin and brain tissue. Analyzing RNA is the next step in the advancement of genomics. GTC is committed to combining the science of RNA with AI to bring this type of innovation to everyday practice of molecular testing in tissue biopsy as well as in liquid biopsy," stated Dr. Maher Albitar, founder, chief medical officer, and chief executive officer of GTC. "These advances were possible because of the collaborative (Co-Op) business model that was adapted by GTC. Collaboration between various Co-Op members accelerates innovation and advances genomics. We are grateful for the support and collaborative efforts of various members of the Co-Op"

Visit GTC at booth #4117 at ASCO (Free ASCO Whitepaper) for more details and highlights on this work and on how to become a member of the Co-Op. The abstracts presented at ASCO (Free ASCO Whitepaper) will be made available on GTC’s website after the ASCO (Free ASCO Whitepaper) meeting.

PureTech to Present at the Jefferies Healthcare Conference

On June 1, 2022 PureTech Health plc (Nasdaq: PRTC, LSE: PRTC) ("PureTech" or the "Company"), a clinical-stage biotherapeutics company dedicated to discovering, developing and commercializing highly differentiated medicines for devastating diseases, reported that Bharatt Chowrira, Ph.D., J.D., President and Chief Business, Legal & Operating Officer, and Julie Krop, M.D., Chief Medical Officer, will participate in a fireside chat at the Jefferies Healthcare Conference in New York City on Thursday, June 9, 2022, at 9:30am EDT (Press release, PureTech Health, JUN 1, 2022, View Source [SID1234615348]). A webcast of the presentation will be available at View Source

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EXACT Therapeutics AS to present at the Annual International Symposium for Therapeutic Ultrasound (ISTU) Conference in Toronto

On June 1, 2022 EXACT Therapeutics AS ("EXACT-Tx", Euronext Growth: EXTX), a clinical-stage biopharmaceutical company with a mission to enhance the therapeutic efficacy of medicines through ultrasound-mediated drug delivery, reported the presentation of preclinical results of Acoustic Cluster Therapy (ACT) in a murine brain model, at the Annual International Symposium for Therapeutic Ultrasound (ISTU) Conference being held on 7th -10th June 2022 in Toronto, Canada (Press release, Exact Therapeutics, JUN 1, 2022, View Source [SID1234615347]).

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The ISTU is a non-profit organization founded in 2001 to increase and diffuse the knowledge of therapeutic ultrasound to the scientific and medical community and facilitate the translation of therapeutic ultrasound techniques into the clinical area for the benefit of patients worldwide.

The work presented by EXACT-Tx at the ISTU demonstrates the possibility of using ACT to help deliver therapeutics to the brain, addressing a significant unmet medical need with close to 98% of drugs in development unable to cross the blood-brain barrier (BBB).

Dr Masha Strømme, Executive Chair EXACT-Tx said: "These data sets have deepened our understanding of the mechanism behind ACT-induced increased BBB permeability and enhanced accumulation of co-injected molecules, and also given us new insights on the spatial and temporal extravasation pattern induced by ACT, important for understanding the mechanism of this therapeutic strategy for drug delivery to the brain."