On June 2, 2022 NanoString Technologies, Inc. (NASDAQ: NSTG), a leading provider of life science tools for discovery and translational research, reported plans to commercially unveil the CosMx Spatial Molecular Imager (SMI) and its new spatial informatics portal during a Spatial Multiomic Symposium, which will be held on Monday, June 6 from noon to 4:00 pm EDT (Press release, NanoString Technologies, JUN 2, 2022, View Source [SID1234615452]). The event will be live-streamed and held in person, and details can be found here: Spatial Multiomics Symposium – NanoString. In addition, scientists will present 20 studies demonstrating the power of NanoString spatial biology platforms during the scientific portion of the AGBT General Meeting.

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CosMx SMI enables high-resolution imaging of more than 1,000 RNA and over 100 protein analytes within morphologically intact whole tissue sections. The technology combines the power of high-plex profiling with high-resolution imaging, allowing researchers to visualize and quantify gene and protein expression at single cell and subcellular resolutions within both fresh frozen and formalin-fixed paraffin-embedded (FFPE) tissue samples. CosMx SMI serves scientists across the continuum of research using a tunable workflow that can prioritize either unbiased whole-slide imaging at high-plex for discovery or high-throughput biology-driven analysis for translation.

NanoString is dedicated to developing spatial biology solutions for any scale of research. The GeoMx DSP is the leading platform for measuring whole transcriptome at high-throughput in multi-cellular functional regions and the CosMx SMI extends capability to single cell and subcellular resolution across the entire tissue section. Together, GeoMx DSP and CosMx SMI technologies provide unprecedented scientific power for novel spatial discoveries.

Spatial biology experiments are data-intensive, creating up to 1 terabyte of data per sample. NanoString is developing a new cloud-based spatial informatics portal that will provide researchers with a scalable solution to store large GeoMx and CosMx datasets, reduce compute times, and enable secure data sharing and collaboration across institutes.

The Spatial Multiomic Symposium will showcase the application of these powerful tools to resolve biological heterogeneity. Attendees will learn about the latest innovations and will have the opportunity to hear how leading experts are applying these technologies to make novel discoveries in immunology, infectious diseases, oncology and neuroscience.

"We believe spatial biology is the next revolution in life sciences, and we’re honored to bring together experts to showcase cutting-edge spatial technologies and techniques," said Brad Gray, president and CEO, NanoString Technologies. "The volume and quality of NanoString-driven science being presented at AGBT 2022 is a testament to the power of our spatial biology ecosystem."

The Spatial Multiomic Summit Agenda: Speakers and Scientific Presentations

Keynote: Spatial gene expression changes in human skin biology induced from spaceflight: Christopher Mason, Ph.D., Professor; Director, WorldQuant Initiative for Quantitative Prediction; Physiology and Biophysics, Weill Cornell Medicine
Spatially resolved, single cell atlas of human pancreatic islets of Langerhans in type 2 diabetic and healthy controls: Grant Kolar, M.D., Ph.D., Assistant Research Professor Director, Research Microscopy and Histology Core, St. Louis University
Deep spatiotemporal insights into COVID-19: a multi-organ study: Arutha Kulasinghe, Ph.D., National Health and Medical Research Council Research Fellow, The University of Queensland
Spatial reconstruction of joint inflammation in rheumatoid arthritis: Kevin Wei, M.D., Ph.D., Assistant Professor of Medicine, Brigham and Women’s Hospital
Spatially resolved Alzheimer’s disease in mouse model: Miranda Orr, Ph.D., Assistant Professor, Gerontology and Geriatric Medicine, Wake Forest University School of Medicine
To learn more and register for the event, please visit: Spatial Multiomics Symposium – NanoString

At AGBT 2022, 20 posters and oral presentations will showcase unique biological insights generated using NanoString’s spatial platforms. These abstracts include studies exploring spatial biology using the GeoMx DSP and the CosMx SMI platforms.

"As single-cell resolution spatial transcriptomics and proteomics pioneer the next frontier in spatial biology, our understanding of fundamental processes in biology will deepen and perhaps pave the way for next-generation diagnostic and pathology tools," said Joe Beechem, chief scientific officer, NanoString Technologies. "The CosMx SMI system is ideal for deeper single-cell exploration downstream of whole transcriptome analysis carried out on GeoMx DSP and the two systems can essentially be used for complementary experiments on a set of samples."

Several studies and presentations that feature NanoString’s spatial biology platforms are highlighted below.

Oral Presentations

Multicellular spatial neighborhoods in pancreatic cancer remodeled by neoadjuvant treatment will be presented by Will Hwang, M.D., Ph.D., radiation oncologist and research fellow, Massachusetts General Hospital Cancer Center/Harvard Medical School, on June 6 from 6:05-6:25 pm. Discover the unique interaction between malignant cells and nerves/microenvironment during the response to treatment for PDAC, using GeoMx DSP and CosMx SMI platforms.

Building a spatial single-cell multi-omics atlas and cellular interactome for skin cancer will be presented by Quan Nguyen, Ph.D., the University of Queensland on June 7 from 7:50-8:10 pm. Learn how CosMx profiling enables spatial interactome analysis that provides new insights in the development of skin cancer. This will be a comparison of six spatial platforms.

High-plex (> 1000), multi-omic (RNA plus protein), spatial molecular imaging with sub-cellular resolution in FFPE tissue, will be presented by Joe Beechem, Ph.D., chief scientific officer, NanoString Technologies. Concurrent sessions will run from 8:50-9:10 pm on June 8. Learn how high-plex multi-omic (RNA and protein) targets detected in FFPE samples using CosMx SMI, at subcellular and single-cell resolution in >1 million cells from a single slide uncovers novel biological insights that were previously lost in space.

Scientific Posters

Poster: Spatial characterization of the tumor microenvironment in pancreatic cancer with whole transcriptome profiling and high plex single-cell imaging.
David Ting, M.D., Chief Medical Information Officer, Mass General Physicians Organization, Co-Director, MGH Center for Innovation in Digital HealthCare, Assistant Professor, Harvard Medical School
See the origin of exosomes in tumor microenvironments and the effect of their migrations in pancreatic cancer tissues using the CosMx SMI platform.

Poster: Characterization of human brain organoids with single-cell resolution and molecular specificity
Florent Ginhoux, Ph.D., Senior Principal Investigator · Singapore Immunology Network, Agency for Science, Technology and Research
Learn how CosMx single-cell imager enables unique analyses and understanding of human brain organoid cells in space.

Poster: Spatially-mapped quantitative single-cell characterization of PD-L1-related RNA microenvironments in triple-negative breast cancer
Aubrey Thompson, Ph.D., Co-director of the Mayo Clinic Breast Cancer Translational Genomics Program
Learn how CosMx and GeoMx spatial platforms generate consistent data for clinical biomarkers of response to IO therapy.

Poster: Spatial Single Cell characterization of SIV reservoirs in lymphoid tissues and B cell follicles in rhesus macaques
Jake Estes, Ph.D., Professor, VGTI-Vaccine and Gene Therapy Institute; Chief, Division of Pathobiology & Immunology, Oregon National Primate Research Center
Uncover how subcellular localization of SIV RNAs in NHP revealed by CosMx and response to drug targets in infected-cell microenvironments studied using GeoMx DSP provides novel analysis tools for vaccine development.

Poster: High-plex spatial single cell in situ analysis of lung SARS-CoV-2
Arutha Kulasinghe, Ph.D., NHMRC Research Fellow, Queensland University of Technology
Discover the consistent insights in COVID biology and biomarkers uncovered by the CosMx SMI and GeoMx DSP platforms at different scales.

To see the complete list of 2022 AGBT posters and learn more about the data presented on the GeoMx DSP and CosMx SMI platforms, visit NanoString’s AGBT event page.

On June 2, 2022 PharmaCyte Biotech, Inc. (NASDAQ: PMCB) (PharmaCyte), a biotechnology company focused on developing cellular therapies for cancer, diabetes and malignant ascites using its signature live-cell encapsulation technology, Cell-in-a-Box, reported that its Board of Directors (Board) has authorized a share repurchase program to repurchase up to $10 million of PharmaCyte’s outstanding common stock (Press release, PharmaCyte Biotech, JUN 2, 2022, View Source [SID1234615451]). The share repurchase authorization is effective immediately for a two-year period. PharmaCyte expects to fund the program with its available cash.

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PharmaCyte’s Chief Executive Officer, Kenneth L. Waggoner, said, "The Board’s decision to establish this share repurchase program reflects our commitment to creating shareholder value, our strong balance sheet and the expectations we have for 2022 and beyond. Because shareholder value is key to our success, our Board began discussing a share repurchase program at a quarterly Board meeting in March of this year.

"It has been decided that since, unlike in year’s past, we are finally in a strong enough financial position we can allocate some of our capital in ways that will generate as much value as possible for our shareholders. In our improved financial position, we will continue to prioritize capital allocation that supports our financial strategies."

The shares may be repurchased from time to time in open market transactions, negotiated block transactions or other means in accordance with Rule 10b-18 of the Securities Exchange Act of 1934, as amended. The timing of the purchase, the number of shares repurchased, and the prices paid for the shares under this program will depend on general business and market conditions, the trading price of PharmaCyte’s common stock and corporate and regulatory limitations, including blackout period restrictions. The share repurchase program does not obligate PharmaCyte to acquire a specific dollar amount or number of shares and may be extended, modified, or discontinued at any time.

To learn more about PharmaCyte’s pancreatic cancer treatment and how it works inside the body to treat locally advanced, inoperable pancreatic cancer, we encourage you to watch PharmaCyte’s documentary video complete with medical animations at: View Source

On June 2, 2022 Sarepta Therapeutics, Inc. (NASDAQ:SRPT), the leader in precision genetic medicine for rare diseases, reported that senior management will participate in a fireside chat at the Goldman Sachs 43rd Annual Global Healthcare Conference on Tuesday June 14, 2022 at 10:00 a.m. P.T./ 1:00 p.m. E.T (Press release, Sarepta Therapeutics, JUN 2, 2022, View Source [SID1234615450]). The fireside chat will be held at the Terranea Resort, Rancho Palos Verdes, CA.

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The presentation will be webcast live under the Events & Presentations section of the investor relations section of Sarepta’s website at View Source and will be archived there following the presentation for 90 days. Please connect to Sarepta’s website several minutes prior to the start of the broadcast to ensure adequate time for any software download that may be necessary.

On June 2, 2022 Pacira BioSciences, Inc. (NASDAQ: PCRX) reported that it will participate in an analyst-led fireside chat at the Jefferies Healthcare Conference at 9:00 AM ET on Thursday, June 9, 2022 in New York (Press release, Pacira Pharmaceuticals, JUN 2, 2022, View Source [SID1234615449]). Live audio of the event can be accessed by visiting the "Events" page of the company’s website at investor.pacira.com. A replay of the webcast will also be available for two weeks following the event.

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On June 2, 2022 Sapience Therapeutics, Inc., a clinical-stage biotechnology company focused on the discovery and development of peptide therapeutics to address difficult-to-treat cancers, reported interim clinical data, including a confirmed PR per mRANO (meaning >50% reduction in tumor measurements) in a glioblastoma (GBM) patient from its ongoing Phase 1-2 study in patients with advanced unresectable and metastatic solid tumors (NCT04478279) (Press release, Sapience Therapeutics, JUN 2, 2022, View Source [SID1234615448]).

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In the Phase 2 expansion portion of the ongoing Phase 1-2 study of ST101, 14 GBM patients have been enrolled to date. Of these 14 patients, one patient has a confirmed PR after 18 weeks of therapy, seven patients have not reached the first on-study assessment, and six patients progressed. In both the Phase 1 and Phase 2 portions of the ongoing study, ST101 has demonstrated a favorable safety profile, with manageable mild-moderate infusion related reactions as the most common adverse event. Based on the confirmed PR announced today, Sapience intends to expand the recurrent GBM cohort to enroll additional patients.

"ST101 is showing promising results in GBM with a PR, which we have confirmed with repeat scans per mRANO and using an independent radiology reviewer. The tumor shrinkage we are seeing is especially encouraging given the significant unmet medical need in this disease and its poor prognosis," said Fabio Iwamoto, Principal Investigator at Columbia University. "Our team at Columbia is thrilled to be a part of this work and to deliver meaningful therapeutic benefit to cancer patients."

Dr. Alice Bexon, Sapience’s Chief Medical Officer, added, "The confirmed response in GBM is very exciting news, which along with the continuing clinical benefit we are seeing from some of the Phase 1 patients, suggests that ST101 could make a major contribution to the treatment of cancer. Based on its novel mechanism of action, ST101 is the first in a new class of peptide therapeutics, and we look forward to advancing our Phase 2 study."

Data from the ST101 Phase 1 study will be presented at the American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) Annual Meeting on Sunday, June 5th, 2022, Abstract #3014.

About ST101 and the Phase 1-2 Study

ST101, a first-in-class antagonist of C/EBPβ, is currently being evaluated in the Phase 2 portion of an ongoing Phase 1-2 clinical study in patients with advanced unresectable and metastatic solid tumors (NCT04478279). ST101-101 is an open-label, two-part, Phase 1-2 dose-finding study designed to determine the safety, tolerability, PK, PD, and proof-of-concept efficacy of ST101 in patients with advanced solid tumors. The study consists of two phases: Phase 1 dose escalation/regimen exploration and Phase 2 expansion. In the ongoing dose escalation study, ST101 has demonstrated clinical proof-of-concept with a durable RECIST 1.1-confirmed partial response (PR) in a patient with cutaneous melanoma and evidence of long-lasting stable disease in several additional patients. In the ongoing Phase 2 dose expansion part of the study, ST101 has demonstrated clinical proof-of-concept with a confirmed partial response in a patient with recurrent GBM. Sapience is actively enrolling patients with GBM, metastatic cutaneous melanoma, locally advanced or metastatic hormone-receptor positive breast cancer and castration-resistant prostate cancer. ST101 has been granted Fast Track designation for recurrent GBM and advanced cutaneous melanoma in patients who have disease progression on or after anti-PD-1/anti-PD-L1 therapy, as well as orphan designations from the FDA for advanced melanoma, glioma and AML, and from the European Commission for the treatment of glioma.