On May 3, 2022 Agastiya Biotech and Vopec Pharmaceuticals reported that the US FDA has granted Orphan Drug Designations for Pancreatic Cancer and AML for its novel small molecule, AB001 (Press release, Agastiya Biotech, MAY 3, 2022, View Source [SID1234613445]).

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AB001 is a small molecule PD-L1 checkpoint inhibitor that also targets aberrant intracellular signaling pathways in the tumor microenvironment, such as Wnt/beta-catenin, PI3K, and RAS. This dual mechanism has been shown in the animal model to work across multiple cancer types, including solid and liquid tumors and, also, on non-PDL1+ cancers. The research offers potential proof for the drug-ability of the so far undruggable beta-catenin and clear advantages of AB001 over Gemcitabine which is the standard of care for pancreatic cancer. Furthermore, AB001 exerts anti-leukemia activity in preclinical models of acute lymphoblastic leukemia, likely through inhibiting VEGFR2-mediated signaling pathways, and suggests potential benefits and clinical application of AB001 in treating Leukemia patients.

Agastiya’s founder Dr. Baskaran Pillai says, "Chemo drugs are efficient in killing tumor cells. However, due to its high toxicity, it also ends up harming normal cells, weakening the patient’s health and energy. AB001 preclinical studies have proved that it is able to kill cancer cells without harming normal cells. Additionally, AB001 targets cancer stem cells, thereby disrupting drug resistance and relapse mechanisms."

Dr. MG Dinesh, Chief Scientific Officer, states, "On the advice of Dr. Pillai, I researched the preventative efficacy of AB001 on 5 different cancer cell lines. The prophylactic studies show that AB001 prevents various oncogenes from becoming mutated into tumors and maintains the tumor suppressor genes in the active state after induction with a chemical carcinogen."

Cancer prevention is one of the important Moonshot project goals of President Biden. "Our India-US collaboration marks an important milestone in cancer therapeutics." Says Sonja Benkovich, interim-CEO.

On May 3, 2022 West Pharmaceutical Services, Inc. (NYSE: WST), a global leader in innovative solutions for injectable drug administration, reported that it will participate in the Bank of America Securities 2022 Healthcare Conference taking place May 9-13, 2022, in Las Vegas, NV (Press release, West Pharmaceutical Services, MAY 3, 2022, View Source [SID1234613444]). Management will present on Tuesday, May 10, 2022, at 11:20 AM PDT.

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It will also present at the 42nd Annual William Blair Growth Stock Conference in Chicago, IL on Monday, June 6, 2022, as well as at the Jefferies Global Healthcare Conference in New York, NY on Thursday, June 9, 2022.

A live audio webcast will be available in the "Investors" section of the Company’s website at www.westpharma.com. Replay of the webcasts will be available for approximately 90 days after the events.

On May 3, 2022 Enveric Biosciences Inc. (NASDAQ: ENVB) ("Enveric" or the "Company"), a neuroscience-focused biotechnology company developing next-generation, psychedelic-inspired mental health medicines, reported that its Board of Directors declared a dividend of one one-thousandth of a share of newly-designated Series C Preferred Stock, par value $0.01 per share, for each outstanding share of Enveric common stock held of record as of 5:00 p.m. Eastern Time on May 13, 2022 (Press release, Enveric Biosciences, MAY 3, 2022, View Source [SID1234613443]). The outstanding shares of Series C Preferred Stock will vote together with the outstanding shares of the Company’s common stock, as a single class, exclusively with respect to a proposal to increase the number of authorized shares of the Company’s common stock, a proposal giving the Board of Directors the authority, as it determines appropriate, to implement a reverse stock split within twelve months following the approval of such proposal by the Company’s stockholders, as well as any proposal to adjourn any meeting of stockholders called for the purpose of voting on the foregoing matters, and will not be entitled to vote on any other matter, except to the extent required under the Delaware General Corporation Law. Subject to certain limitations, each outstanding share of Series C Preferred Stock will have 1,000,000 votes per share (or 1,000 votes per one one-thousandth of a share of Series C Preferred Stock).

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All shares of Series C Preferred Stock that are not present in person or by proxy at the meeting of stockholders held to vote on the above described proposals as of immediately prior to the opening of the polls at such meeting will automatically be redeemed by the Company. Any outstanding shares of Series C Preferred Stock that have not been so redeemed will be redeemed if such redemption is ordered by Enveric’s Board of Directors or automatically upon the approval by Enveric’s stockholders of the above described proposals.

The Series C Preferred Stock will be uncertificated, and no shares of Series C Preferred Stock will be transferable by any holder thereof except in connection with a transfer by such holder of any shares of the Company’s common stock held by such holder. In that case, a number of one one-thousandths of a share of Series C Preferred Stock equal to the number of shares of Enveric’s common stock to be transferred by such holder would be transferred to the transferee of such shares of common stock.

Further details regarding the Series C Preferred Stock will be contained in a report on Form 8-K to be filed by Enveric with the Securities and Exchange Commission.

On May 3, 2022 AngioDynamics, Inc. (NASDAQ: ANGO), a leading and transformative medical technology company focused on restoring healthy blood flow in the body’s vascular system, expanding cancer treatment options, and improving quality of life for patients, reported that Jim Clemmer, President and Chief Executive Officer, and Stephen Trowbridge, Executive Vice President and Chief Financial Officer, will present at the BofA Securities Healthcare Conference at 10:00 a.m. PT (1:00 p.m. ET) on Tuesday, May 10, 2022 (Press release, AngioDynamics, MAY 3, 2022, View Source [SID1234613442]).

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A live webcast of the presentation will be accessible through the "Investors" section of the Company’s website at www.angiodynamics.com and will be available for replay following the event.

On May 3, 2022 Aura Biosciences Inc. (NASDAQ: AURA), a clinical-stage biotechnology company developing a novel class of virus-like drug conjugate (VDC) therapies for multiple oncology indications, reported the presentation of preclinical data for its first VDC product candidate, AU‑011 (Press release, Aura Biosciences, MAY 3, 2022, View Source [SID1234613440]). AU-011 is in development for the treatment of multiple ocular oncology indications, including primary choroidal melanoma and choroidal metastasis. The results presented today highlight AU-011’s targeted cytotoxicity towards tumor cells derived from the most common cancer types known to metastasize to the choroid. The results were presented as part of the 2022 Association of Research in Vision and Ophthalmology (ARVO) Annual Meeting taking place in Denver, CO on May 1 – 4 and virtually on May 11 – 12.

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"The data presented at ARVO demonstrates AU-011’s potent cytotoxicity in human cancer cell lines as well as in multiple in vivo tumor models including breast, renal and colon cancer which are well known to metastasize to the choroid," said Elisabet de los Pinos, Ph.D., Chief Executive Officer of Aura. "These results support our commitment to build our ocular oncology franchise and provide a potential novel treatment for patients with cancers in the eye. We look forward to submitting the IND in choroidal metastases in the second half of this year."

In vitro potency was observed across a panel of human cancer cell lines. Cells were treated with AU-011 followed by light activation, and dose-dependent cell binding and cytotoxicity were noted. Addition of heparin to the binding studies prevented AU-011 association with the tumor cells demonstrating AU-011’s specific targeting of tumor associated heparan sulfate proteoglycans (HSPGs). Syngeneic murine models of breast, colon, and renal cancer were employed to evaluate AU-011’s anti-tumor activity in vivo and dose-dependent efficacy was observed across all models. The studies herein support further development of AU-011 for choroidal metastasis.

Details for the presentation are as follows:

Title: A first in class Virus-Like Drug Conjugate (VDC) shows anti-tumor activity in Cancers that Commonly Metastasize to the Choroid
Presentation Number: 2616
Presenter: Anneli Savinainen, Aura Biosciences
Session Title: Where art thou tumor? – Ocular tumor physiology and metastases
Date and time: Tuesday, May 3 at 3:00 – 3:17 PM ET
Location: 1AB Mile High Ballroom (Denver Convention Center)

The presentation can be accessed by visiting the "Scientific Presentations" section of "VDC Platform" page of the Aura Biosciences website.