On April 26, 2022 Kintara Therapeutics, Inc. (Nasdaq: KTRA) ("Kintara" or the "Company"), a biopharmaceutical company focused on the development of new solid tumor cancer therapies, reported that President and CEO Robert E. Hoffman will present a corporate overview at the Planet MicroCap Showcase 2022 (Press release, Kintara Therapeutics, APR 26, 2022, View Source [SID1234612944]). The conference is being held on May 3 – 5, 2022 at The Bally’s Hotel & Casino in Las Vegas, NV.

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Mr. Hoffman will be available for one-on-one meetings. To request a meeting and to register for the conference, click here: View Source

On April 26, 2022 Iovance Biotherapeutics, Inc. (NASDAQ: IOVA), a late-stage biotechnology company developing novel T cell-based cancer immunotherapies, reported that it will report its first quarter financial results on Thursday, May 5, 2022 (Press release, Iovance Biotherapeutics, APR 26, 2022, View Source [SID1234612943]). Management will host a conference call and live audio webcast to discuss these results and provide a corporate update at 4:30 p.m. ET.

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To participate in the conference call, please dial 1-844-646-4465 (domestic) or 1-615-247-0257 (international) and reference the access code 4655146. The live webcast can be accessed in the Investors section of the Company’s website at www.iovance.com. The archived webcast will also be available for one year in the Investors section at www.iovance.com.

On April 26, 2022 Symeres reported the acquisition of Organix, a US-based provider of high-quality organic chemistry services (Press release, Symeres, APR 26, 2022, View Source [SID1234612940]). The company is dedicated to the discovery and preclinical stage of the drug-discovery value chain, with a focus on lipids and small molecules. Organix has 47 employees, the majority of which have a PhD in chemistry, and is based in Woburn, in the Boston, MA, area. Its revenue is mainly generated from the sale of specialized and complex organic chemistry research services to biopharma clients.

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Symeres and Organix are highly complementary, and the combination unlocks significant strategic value. Organix represents a high-quality foothold into the US market, where Symeres already generates about 40% of its revenues. Furthermore, Organix broadens the Symeres drug-discovery offering into the fast-growing lipids market, addressing mRNA therapeutics and vaccines. Organix’s impressive client list includes some of the world’s leading biopharma companies, many based in the Boston biopharma community. Organix management will remain unchanged; the company is led by Dr. Anu Mahadevan, CEO, and Dr. Paul Blundell.

Symeres CEO Eelco Ebbers is very pleased to quickly integrate Organix into the Symeres group: "Organix is widely known as being highly innovative and an expert organic chemistry services provider that is able to solve complex projects for top-tier clients globally. Joining forces represents a fantastic opportunity for us to expand our drug-discovery-capability offering and provide an exceptional high-quality foothold into the US market."

As the majority shareholder in Symeres, Keensight Capital has worked together with the management team of the two companies to facilitate this combination. Amit Karna, Partner at Keensight Capital, comments: "We are delighted to support Symeres in this exciting acquisition of Organix. We are certain that the resulting business will create a truly differentiated transatlantic offering for the biopharma industry, with significant expertise in molecule design, synthesis, and early-stage clinical manufacturing. Moreover, the scientific and cultural fit of the two organizations could not be more perfect, and we are excited to see what the management teams will achieve together."

On April 25, 2022 AI Therapeutics, Inc., an AI driven clinical-stage biopharmaceutical company developing novel therapeutics for rare diseases, reported the acquisition of EntreChem, S.L.’s investigational drug candidate EC-8042 (redesignated AIT-102), a novel targeted cancer therapy in development for rare pediatric and other cancers (Press release, EntreChem, APR 25, 2022, View Source [SID1234648560]).

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Despite recent advances in the understanding of tumor biology, treatment for many pediatric cancers remains limited to surgery, radiation and chemotherapy which often have poor outcomes and are associated with significant side effects. AIT-102 specifically targets the mutations responsible for the formation and progression of two notable pediatric tumors, rhabdoid tumors and Ewing sarcoma, and holds the potential to treat a broader family of tumors that share a common mechanism of mutated or dysregulated SWI/SNF activity.

"As a physician treating children with cancer on a daily basis, I am acutely aware of the need for more effective and less toxic therapies," said Patrick Grohar, M.D., Ph.D., Director of Translational Research with the Center of Childhood Cancer Research at Children’s Hospital of Philadelphia, a leader in the study and treatment of pediatric tumors. "For many tumor types, the biological culprit is well understood, but has proven difficult to target with pharmaceuticals. I have dedicated the last 15 years of my professional career to understanding the mechanism of tumor biology in children and finding new, targeted, therapies to treat these tumors. I am particularly impressed with the strong preclinical data from our studies of AIT-102 in rhabdoid tumors and Ewing sarcoma, and I believe that AIT-102 has the potential to transform the treatment of these cancers, as well as many others."

"AIT-102 is a powerful addition to AI Therapeutics’ rare disease treatment pipeline," said Brigette Roberts, M.D., Chief Executive Officer of AI Therapeutics. "Cancer is the leading cause of death by disease in children in the US today. With AIT-102, we hope to change these statistics. Beyond pediatrics, AIT-102 has the potential to treat up to 20% of cancers with altered SWI/SNF activity, either through mutation or dysregulation, including epithelioid sarcoma, synovial sarcoma, lung adenocarcinoma, colorectal cancer, and others. We are thrilled to have this opportunity to bring forward a promising new agent to help fight these tumors."

Financial terms of the transaction were not disclosed.

On 25 April 2022 Epitopea, a transatlantic cancer immunotherapeutics company and global leader in exploiting a new class of untapped tumour-specific antigens (TSAs), reported a $13.6M (£10.3M) seed investment from a transatlantic syndicate of top-tier life sciences investors, including Advent Life Sciences, CTI Life Sciences, Cambridge Innovation Capital (CIC) and Fonds de solidarité FTQ (Press release, Epitopea, APR 25, 2022, View Source [SID1234632198]). The seed round was also supported by Novateur Ventures and the Harrington Discovery Institute/University Health Holdings. The funding will leverage Epitopea’s ground-breaking CryptigenTM approach to create transformational immunotherapies that target broad cancer patient populations in both solid and haematological cancers.

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The company’s proprietary technology provides an innovative approach to identifying shared, aberrantly expressed tumour specific antigens, known as CryptigensTM, that it has exclusively licensed from the Université de Montréal (UdeM). The licensing deal was catalysed by IRICoR, a Canadian Centre of Excellence in Commercialization and Research, which supported and incubated the development of the technology. CryptigenTM TSAs are uniquely and broadly presented across cancer types, providing tumour-specific targets for immunotherapies that are predicted to kill malignant cells while sparing non-cancerous cells, potentially delivering significant therapeutic benefit across broad patient populations with minimal side effects.

The seed round funding will be used to build the company’s executive team, advance further research on this new class of antigens, and catalyse their translation into novel cancer immunotherapeutics, including therapeutic vaccines, cell therapies, and TCR-based biologics.

Dr Jon Moore, CEO, Epitopea and Operating Partner at Advent Life Sciences, said

"The outstanding work of Epitopea’s co-founders, Université de Montréal scientists Drs. Claude Perreault, and Pierre Thibault, has opened a tremendous and potentially transformative opportunity for future cancer patients. With this significant seed financing by a syndicate of world-class investors from Canada and the UK, we can start translating these discoveries into novel therapeutics. We will be guided by science, deploying the best modalities available to help cancer patients achieve durable benefits."

Dr Laurence Rulleau, Partner, CTI Life Sciences, said

"CTI is delighted to co-lead the seed round of Epitopea, which is the first investment from our third fund, CTI LSF III. We are convinced that Epitopea has the potential to fundamentally change the paradigm of how cancer patients can be treated with therapeutics vaccines and other immunotherapies to significantly improve their quality of life. Epitopea will explore a variety of early and longer-term value creation strategies including partnerships with third parties as well as developing its own therapeutic modalities based on its CryptigenTM TSAs."