Iktos and Teijin Pharma to Co-Develop New Technology for Small Molecule Drug Discovery

On April 5, 2022 Iktos, a company specialized in Artificial Intelligence (AI) for new drug design, and Teijin Pharma Limited, the core company of the Teijin Group’s healthcare business that provides comprehensive healthcare services to improve the quality of life, reported a strategic collaboration agreement in Artificial Intelligence for new drug design (Press release, Iktos, APR 5, 2022, View Source [SID1234613367]).

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Under the agreement, Iktos generative modelling technology will be implemented and applied to several Teijin Pharma’s small molecule drug discovery projects to expedite the identification of potential pre-clinical candidates. Iktos and Teijin Pharma will collaborate in developing new AI technology aiming to bring further improvement and speed to the drug design process, leveraging Iktos’ proprietary know-how in AI for Computer Aided Drug Design (CADD) and complementing Teijin’s research and development capabilities.

In the recent years, Iktos has emerged as one of the world leaders in AI for drug design, establishing multiple collaborations with renowned pharmaceutical companies and successfully developing the AI software platforms Makya for new drug design and Spaya for synthesis planning. Iktos’ generative AI technology, based on deep generative models, automatically designs virtual novel molecules presenting the desirable characteristics specified by the researchers. This approach brings unprecedented efficiency in the exploration of chemical space and produces innovative molecule designs with greater freedom to operate. It is a novel solution, validated through many collaborations, to one of the key challenges in drug design: the rapid identification of molecules that simultaneously satisfy multiple parameters, such as potency, selectivity, safety, and project-specific properties.

Based on the recent drastic demographic change and increased health consciousness, Teijin Pharma is committed to providing healthcare solutions in the priority fields of bone, joint, rehabilitation, neurology, respiratory, cardiovascular and metabolic diseases. Creating innovative drugs is one of the company’s core business strategies and Teijin Pharma is now focusing on strengthening technological foundation for small molecule drugs that play major roles among the drug modalities for innovative drug discovery.

"We are thrilled and proud to announce a strategic collaboration with Teijin Pharma, a leading company that contributes to society by providing advanced healthcare solutions.’’ said Yann Gaston-Mathé, Co-founder and CEO of Iktos. "It is a major recognition for Iktos to be selected by Teijin Pharma as a strategic partner for implementation, development, and application of generative modeling technology for new drug design. Iktos has been a pioneer in the application of generative models for drug discovery and is recognized as a world leader in the technology space that has the potential to disrupt the way new therapeutics are designed.’’ "Our ultimate objective is to expedite drug discovery and achieve time and cost efficiencies for our global collaborators by using Iktos’s proprietary AI platform and know-how. We are confident that together with our Teijin collaborators, we will be able to develop new technology to bring further speed and efficiency to drug discovery."

"We are delighted to create innovative new small molecule drugs together with Iktos," said Ichiro Watanabe, President of Teijin Pharma. "We provide solutions in the field of demographic change and increased health consciousness and are focusing on the launch of new drugs. Iktos’ proprietary AI technology will dramatically accelerate our small molecule drug discovery. We continue to enhance patients’ quality of life by providing new treatment options for diseases with high unmet needs."

AACR-2022 NI-2601 & NI-2901 CD47xPD-L1 bispecific antibodies

On April 5, 2022 Light Chain Bioscience reported The American Association for Cancer Research (AACR) (Free AACR Whitepaper) will host its Annual Meeting April 8-13, 2022 (Press release, Light Chain Bioscience, APR 5, 2022, View Source [SID1234611832]). Light Chain Bioscience is very pleased to have Xavier Chauchet attend in-person.

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Xavier will be presenting two posters #3225 and #3283 describing differentiating CD47xPD-L1 bispecific #antibody approaches, NI-2601 & NI-2901.

"NI-2601, an Fc-active CD47xPD-L1 bispecific antibody that selectively targets CD47 on PD-L1-positive tumors" (#3283) will be exposed and presented on April 12 between 1:30-5:00 p.m.

↠ Read 1st poster – Poster section 32 [PDF]:

aacr 2022 ni 2901 cd47xpd l1 bispecific antibody for dual immune checkpoint blockade 2601

"NI-2901, a CD47xPD-L1 bispecific antibody for dual immune checkpoint blockade with fine-tuned affinity to reduce erythrocyte binding and improve biodistribution" (#3225) will be exposed and presented on April 12 between 1:30-5:00 p.m.

↠ Read 2nd poster – Poster section 32 [PDF] :

aacr 2022 ni 2901 cd47xpd l1 bispecific antibody for dual immune checkpoint blockade 2901

Ernest N. Morial Convention Center New Orleans, Louisiana

900 Convention Center Blvd, New Orleans, LA 70130, United States

Biogen to Report First Quarter 2022 Financial Results May 3, 2022

On April 5, 2022 Biogen Inc. (Nasdaq:BIIB) reported it will report first quarter 2022 financial results Tuesday, May 3, 2022, before the financial markets open (Press release, Biogen, APR 5, 2022, View Source [SID1234611518]).

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Following the release of the financials, the Company will host a live webcast with Biogen management at 8:00 a.m. ET. To access the live webcast, please go to the investors section of Biogen’s website at investors.biogen.com. Following the live webcast, an archived version of the call will be available on the website.

TD2 Highlights Two Novel HDAC Inhibitors at AACR Annual Meeting

On April 5, 2022 Translational Drug Development (TD2), a precision oncology contract research organization (CRO), reported the presentation of the preclinical results of two novel, targeted epigenetic inhibitors at the American Association for Cancer Research (AACR) (Free AACR Whitepaper) Annual Meeting in New Orleans, LA., to be held April 8-13, 2022 (Press release, Research Corporation Tech, APR 5, 2022, View Source [SID1234611500]).

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Two posters will be presented at AACR (Free AACR Whitepaper) that discuss the exciting preclinical results from the development of isoform-selective HDAC inhibitors, GB-1101 and GB-3103. The posters will highlight the potential synergies of these HDAC inhibitors with PARP and immune checkpoint inhibitors and the impact on tumor immune microenvironment and tumor progression in models of murine breast, human neuroendocrine prostate, and small cell lung cancers.

"The highly selective HDAC6 inhibitor GB-1101 reprogrammed the tumor immune microenvironment and elicited tumor regressions when combined with checkpoint inhibitors. These data suggest that GB-1101 could be an important new targeted epigenetic immunomodulator able to revoke immune privilege to enhance the clinical activity of immune checkpoint therapies," said Paul Gonzales, Vice President of Nonclinical Operations at TD2. "The potent HDAC3 selective GB-3103 showed broad inhibition of genes in DNA repair pathways and could have utility in enhancing PARP inhibitor activity in homologous repair proficient cancers, or in overcoming PARP inhibitor resistance in homologous repair-deficient tumors."

TD2 will be onsite at AACR (Free AACR Whitepaper) to discuss these important results as well as host an exhibitor booth, #1861.

Abstract 1359: Selective HDAC6 Inhibition By GB-1101 Revokes Tumor Immune Privilege and Synergizes with Immune Checkpoint Therapies to Induce Tumor Regressions (Monday, April 11, 9:00 AM – 12:30 PM CST) Molecular Signaling and Metabolic and Epigenetic Regulation in Adaptive Tumor Immunity Poster Session, Section 37, Poster Board Number 18

Abstract 2607: Inhibition of HDAC3 Induces BRCAness and Potent Synergy with PARP Inhibition in Neuroendocrine Prostate and Small Cell Lung Cancers (Tuesday, April 12, 9:00 AM – 12:30 PM CST) DNA Damage Response and Repair Poster Session, Section 22, Poster Board Number 20

Regeneron to Report First Quarter 2022 Financial and Operating Results and Host Conference Call and Webcast on May 4, 2022

On April 5, 2022 Regeneron Pharmaceuticals, Inc. (NASDAQ: REGN) reported that it will report its first quarter 2022 financial and operating results on Wednesday, May 4, 2022, before the U.S. financial markets open (Press release, Regeneron, APR 5, 2022, View Source [SID1234611493]). The Company will host a conference call and simultaneous webcast at 8:30 AM Eastern Time that day.

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Conference Call Information
Participants may access the conference call live via webcast on the ‘Investors and Media’ page of Regeneron’s website at View Source To participate via telephone, please register in advance at this link. Upon registration, all telephone participants will receive a confirmation email detailing how to join the conference call, including the dial-in number along with a unique passcode and registrant ID that can be used to access the call. A replay of the conference call and webcast will be archived on the Company’s website for at least 30 days.