On April 28, 2022 Lunit reported the presentation of 11 abstracts featuring its AI-biomarker platform at the 2022 ASCO (Free ASCO Whitepaper) Annual Meeting from June 3 to 7 (Press release, Lunit, APR 28, 2022, View Source [SID1234613187]).

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Since 2019, the company has presented groundbreaking findings based on its AI-powered tissue analysis platform, ‘Lunit SCOPE.’ This year’s ASCO (Free ASCO Whitepaper) Meeting will showcase the largest number of studies by Lunit, including seven poster presentations and four online publications.

One of Lunit’s presentations will focus on the use of AI technology to define tumor immune phenotypes. Findings from the study validate the effectiveness of Lunit SCOPE IO—Lunit’s AI biomarker—in predicting clinical outcomes of immunotherapy across more than 16 different cancer types.

Lunit’s other major study assesses the practical efficacy of Lunit SCOPE PD-L1, an AI-powered PD-L1 tumor proportion score (TPS) analyzer, which recently has received a CE mark.

In addition, Lunit will also present clinical findings that demonstrate the accuracy of its AI imaging solution in detecting high-risk breast cancer patients.

The company’s four abstracts due to be published online include a joint study to evaluate the performance of ‘Lunit SCOPE HER2’ in reducing interobserver variation among pathologists, as well as an examination of the landscape of tumor-infiltrating lymphocytes (TIL) in neuroendocrine tumors, a rare form of cancer, by using Lunit SCOPE IO.

"Through several studies, Lunit has demonstrated the credibility of Lunit SCOPE IO as a practical biomarker to predict cancer patients’ response to immunotherapy," said Chan-Young Ock, Chief Medical Officer at Lunit. "This study validates the efficacy of our AI biomarker as we continue to expand the range of our research across all cancer types originating from the epithelium."

On April 28, 2022 Illumina, Inc. (NASDAQ: ILMN) reported that its executives will be speaking at the following investor conference (Press release, Illumina, APR 28, 2022, View Source [SID1234613186]):

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BofA Securities 2022 Healthcare Conference on May 12, 2022
Fireside Chat at 12:00pm Pacific Time (3:00pm Eastern Time)
The live webcast can be accessed under the Investor Info section of Illumina’s website under the "company" tab at www.illumina.com. A replay will be posted on Illumina’s website after the event and will be available for at least 30 days following.

On April 28, 2022 Vanda Pharmaceuticals Inc. (Vanda) (Nasdaq: VNDA) reported it will release results for the first quarter 2022 on Thursday, May 5, 2022, after the market closes (Press release, Vanda Pharmaceuticals, APR 28, 2022, View Source [SID1234613185]).

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Vanda will host a conference call at 4:30 PM ET on Thursday, May 5, 2022, during which management will discuss the first quarter 2022 financial results and other corporate activities. To participate in the conference call, please dial 1-866-688-9426 (domestic) or 1-409-216-0816 (international) and use passcode 1355275.

The conference call will be broadcast simultaneously and archived on Vanda’s website, www.vandapharma.com. Investors should go to the website at least 15 minutes early to register, download, and install any necessary audio software.

A replay of the call will be available on Thursday, May 5, 2022, beginning at 7:30 PM ET and will be accessible until Thursday, May 12, 2022, at 7:30 PM ET. The replay call-in number is 1-855-859-2056 for domestic callers and 1-404-537-3406 for international callers. The passcode number is 1355275.

On April 28, 2022 Transcenta Holding Limited ("Transcenta") (HKEX: 06628), a clinical stage biopharmaceutical company with fully-integrated capabilities in discovery, research, development and manufacturing of antibody-based therapeutics, reported that the abstracts of TST001 and MSB0254 have been accepted by the 2022 annual meeting of American Society of Clinical Oncology (ASCO) (Free ASCO Whitepaper) ("2022 ASCO (Free ASCO Whitepaper) Annual Meeting") (Press release, Transcenta, APR 28, 2022, View Source [SID1234613184]). The abstracts are named "A Phase I Study of TST001, a High Affinity Humanized Anti-CLDN18.2 Monoclonal Antibody, in Combination with Capecitabine and Oxaliplatin (CAPOX) as a First Line Treatment of Advanced G/GEJ Cancer" and "A Phase I Study to Evaluate the Safety, Tolerability and Pharmacokinetics of MSB0254 in Chinese Solid Tumor Patients" respectively.

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The ASCO (Free ASCO Whitepaper) Annual Meeting showcases the most cutting-edge research in clinical oncology and state-of-the-art advanced cancer therapies and is the world’s most influential and prominent scientific gathering of the clinical oncology community. This year’s ASCO (Free ASCO Whitepaper) Annual Meeting will take place both online and in-person (McCormick Place; Chicago, IL) on June 3–7, 2022.

TST001 (Claudin18.2)
Abstract Number: 4062
Session Date and Time: June 4, 2022, 8:00 AM-11:00 AM CDT
Title: A Phase I Study of TST001, a High Affinity Humanized Anti-CLDN18.2 Monoclonal Antibody, in Combination with Capecitabine and Oxaliplatin (CAPOX) as a First Line Treatment of Advanced G/GEJ Cancer
First author: Professor Jifang Gong, Peking University Cancer Hospital and Research Institute
Presentation Format: Poster

MSB0254 (VEGFR2)
Abstract Number: 3023
Session Date and Time: June 5, 2022, 8:00 AM-11:00 AM CDT
Title: A Phase I Study to Evaluate the Safety, Tolerability and Pharmacokinetics of MSB0254 in Chinese Solid Tumor Patients
First author: Professor Tianshu Liu, Zhongshan Hospital, Fudan University
Presentation Format: Poster

About TST001

TST001 is a high affinity humanized anti-Claudin18.2 monoclonal antibody with enhanced antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC) activities and potent anti-tumor activities in tumor xenograft models. TST001 is the second Claudin18.2 targeting antibody therapeutic candidate being developed globally. TST001 is generated using Transcenta’s Immune Tolerance Breaking Technology (IMTB) platform. TST001 kills Claudin18.2 expressing tumor cells by mechanisms of antibody-dependent cellular cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Leveraging advanced bioprocessing technology, the fucose content of TST001 was significantly reduced during the production, which further enhanced NK cells mediated ADCC activity of TST001. Clinical trials for TST001 are ongoing in China and US (NCT04396821, NCT04495296/CTR20201281). TST001 was granted Orphan Drug Designation in the US by FDA for the treatment of patients with gastric cancer or gastroesophageal junction (GC/GEJ).

About MSB0254

MSB0254 is a high affinity humanized anti-VEGFR-2 mAb, with an anti-tumor mechanism of action by inhibiting tumor angiogenesis. MSB0254 has been generated using Transcenta’s in-house antibody discovery platform. VEGFR-2 is overexpressed in neovascular tumor endothelial cells in many tumors in comparison to normal endothelial cells. Vascular permeability, survival and migration of the vascular endothelial cells are controlled by the VEGFR-2 pathway. VEGFR-2 inhibitors has been shown to be able to inhibit tumor-induced angiogenesis and effectively block tumor growth, and thus may have a potential therapeutic role in multiple tumor types.

On April 28, 2022 Veracyte, Inc. (Nasdaq: VCYT) reported that three abstracts highlighting new data on the genomic underpinnings of prostate and bladder cancers will be presented at the American Urological Association Annual Meeting, taking place May 13-16, 2022, in New Orleans (Press release, Veracyte, APR 28, 2022, View Source [SID1234613183]). The findings are derived from analyses of the Decipher GRID, a database that contains genomic profiling information from clinical samples used in the development and commercial application of the Decipher Prostate and Decipher Bladder tests.

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"The data being presented at AUA 2022 highlight the transcriptional complexity of prostate and bladder cancers, knowledge that we hope can be used to better personalize therapy," said Elai Davicioni, Ph.D., Veracyte’s medical director for Urology. "Importantly, these analyses also reinforce the value of our Decipher GRID database, which contains over 100,000 transcriptomes of prostate and bladder cancers, for urologic oncology researchers all around the world."