aTyr Pharma to Present at Upcoming Investor Conferences in March

On March 3, 2022 aTyr Pharma, Inc. (Nasdaq: LIFE), a biotherapeutics company engaged in the discovery and development of innovative medicines based on novel biological pathways, reported that Sanjay S. Shukla, M.D., M.S., President and Chief Executive Officer, will present at two upcoming investor conferences in March (Press release, aTyr Pharma, MAR 3, 2022, View Source [SID1234609484]).

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Details of the events are as follows:

Conference: 34th Annual ROTH Conference
Date: March 13 – 15, 2022
Time: Pre-recorded Corporate Presentation available on demand

Conference: Oppenheimer 32nd Annual Healthcare Conference
Date: Wednesday, March 16, 2022
Time: Live virtual Corporate Presentation at 4:40pm EDT / 1:40pm PDT

In addition to the presentations, company management will be available to participate in one-on-one meetings with investors who are registered attendees of the conferences. Following the events, a replay of each presentation will be available on the Investor’s section of the company’s website at www.atyrpharma.com.

Fortress Biotech Announces Virtual Two-Day Corporate Access Summit Hosted by B. Riley Securities on Tuesday, April 5 and Wednesday, April 6, 2022

On March 3, 2022 Fortress Biotech, Inc. (NASDAQ: FBIO) ("Fortress"), an innovative biopharmaceutical company focused on efficiently acquiring, developing and commercializing or monetizing promising therapeutic products and product candidates, reported a two-day summit hosted by the B. Riley Securities’ Healthcare Equity Research team, that will feature multiple programs from Fortress’ diversified pipeline (Press release, Fortress Biotech, MAR 3, 2022, View Source [SID1234609483]). The events will be held virtually on Tuesday, April 5, and Wednesday, April 6, 2022, beginning at 1:00 p.m. ET each day.

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Registration links and more details will be provided approximately two weeks prior to the summit.

Following each event, the webcast will be available on the News / Events page, located within the Investors section of Fortress’ website, View Source, for approximately 30 days.

Autolus Therapeutics Announces Publication Describing Novel Cell Programming Technology

On March 3, 2022 Autolus Therapeutics plc (Nasdaq: AUTL), a clinical-stage biopharmaceutical company developing next-generation programmed T cell therapies, reported the publication of an article in BioTechniques describing a novel technology that provides for very low levels of expression of one gene module, while maintaining high levels of expression of other gene modules expressed from the same promotor1 (Press release, Autolus, MAR 3, 2022, View Source [SID1234609482]).

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This technical paper describes a method of achieving very low levels of transgene expression in multi-cistronic mammalian expression systems. This is achieved via the insertion of a stop codon and translational readthrough motif (TRM) between the transgenes of an mRNA encoding a multi-cistronic cassette. The TRM helps to suppress the stop codon, facilitating continued translation of the downstream transgene at reduced levels compared with the upstream transgene. This system addresses a fundamental challenge in cell therapy when highly potent receptors, cytokines or toxins are expressed, which, at normal levels of expression, would be unsafe for patients.

"Throughout the history of gene-therapy the primary focus was on engineering mammalian expression cassettes driving high levels of transgene expression," said James Sillibourne, director of synthetic genomics at Autolus. "However, with a very potent or toxic transgene, you need a very low level of expression. Up until now, an easy way of achieving this was not available. Building on mechanisms known from bacteria and viruses, we have developed a reliable way of tightly controlling low levels of transgene expression."

IL-12 is a potent anti-tumor cytokine. However, the majority of clinical studies involving treatment of patients with IL-12 have been associated with severe systemic side effects and significant toxicities for patients.

"Our approach to solid tumors combines multiple gene modules in CAR T cells to drive the desired set of properties we believe are essential to maximize anti-tumor activity without increasing toxicity. Selectively adjusting expression levels became an important technology to establish therapeutic windows," added Martin Pule, chief scientific officer and founder of Autolus. "In this paper we successfully applied this technology for highly restricted IL-12 release which increases CAR T anti-tumor activity in an immunocompetent mouse model without inducing systemic toxicity."

1. Sillibourne JE, Agliardi G, Righi M et al. A compact and simple method of achieving differential transgene expression by exploiting translational readthrough. BioTechniques doi: 10.2144/btn-2021-0079 (2022) (Epub ahead of print). The full publication in BioTechniques can be viewed here.

Enveric Biosciences to Participate in Upcoming Investor Conferences in March 2022

On March 3, 2022 Enveric Biosciences (NASDAQ: ENVB) ("Enveric" or the "Company"), a cutting-edge neuroscience company developing next-generation, psychedelic-inspired mental health medicines, reported that Dr. Joseph Tucker, Chief Executive Officer of Enveric Biosciences, will participate in three upcoming investor conferences (Press release, Enveric Biosciences, MAR 3, 2022, View Source [SID1234609478]):

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Q1 Virtual Investor Summit
Tuesday, March 8th at 11:45 a.m. ET
To attend, please register here.

Citi’s Psychedelic Drug Call Series
Thursday, March 10th at 10:00 a.m. ET
A fireside chat hosted by Neena Bitritto-Garg, Citi’s Biotech analyst.

Maxim 2022 Virtual Growth Conference
Monday, March 28th – Wednesday, March 30th
To attend, please register here.

For more information about the events, or to schedule a one-on-one meeting with Enveric’s management team, please contact your appropriate Investor Summit Group, Citi, or Maxim representative, respectively, or send an email to KCSA Strategic Communications at [email protected].

HUTCHMED announces retirement of CEO and appointment of new CEO

On March 3, 2022 "HUTCHMED" or the "Company (Nasdaq/AIM:​HCM; HKEX:​13) reported the retirement of Mr. Christian Hogg after almost 22 years with the Company, including 15 years as Executive Director and Chief Executive Officer ("CEO"); and the appointment of Dr. Weiguo Su, who has been with the Company for about 17 years, including about 10 years as Chief Scientific Officer ("CSO") and almost five years as Executive Director, as the new CEO (Press release, Hutchison China MediTech, MAR 3, 2022, View Source [SID1234609477]).

Dr. Su has been selected and appointed to his additional role as the CEO, as part of the Company’s ongoing succession planning. Since joining the Company in 2005, Dr. Su has been responsible for the establishment of all aspects of the oncology/immunology innovation platform which led to the in-house discovery of 12 novel oncology drug candidates of the Company, the first three of which have achieved approval and successful commercial launch. When assuming the new position, Dr. Su will combine the crucial research and development function of the Company for which he has been responsible, with the lead executive role as the CEO.

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Prior to HUTCHMED, Dr. Su, aged 64, spent fifteen years in the U.S. Research and Development organization of Pfizer, Inc. and before that, seven years completing his PhD and Post-Doctoral Fellowship in Chemistry at Harvard University under the guidance of Nobel Laureate, Professor E. J. Corey. Dr. Su received a Bachelor of Science degree in Chemistry from Fudan University in Shanghai.

In March 2017, Dr. Su was granted the prestigious award by the China Pharmaceutical Innovation and Research Development Association (PhIRDA) as one of the Most Influential Drug R&D Leaders in China.

While Dr. Su will remain as the CSO for the time being, as part of the ongoing succession planning of the Company, Dr Su, the Nomination Committee and the Board will identify appropriate candidates to take up the leadership of its research and development function.

Mr. Christian Hogg, retiring CEO of HUTCHMED, said "After over 34 years away, and 27 years in China, I have taken the decision to return home to Europe to focus on, and be close to, my important family responsibilities. I am glad to see the Board’s new appointment of Dr. Weiguo Su, one of the industry’s most respected leaders, and a person who I believe, with the support of our board and deeply experienced senior management team, will take HUTCHMED to greater heights. I would like to thank all HUTCHMED colleagues and stakeholders for the support they have given me and I look forward to their continued success."

Mr. Simon To, Chairman of HUTCHMED said, "Christian was the first employee of HUTCHMED twenty-two years ago and he has worked tirelessly to build the Company from its very beginning into the truly globally facing biopharmaceutical company it is today. Christian will remain as a strategic advisor to the Company, with an emphasis on organizational development, relations with our partners, global commercialization strategy and investor relations matters."

Mr. To continued, "On behalf of the Board, I would like to congratulate Dr. Su on his appointment to CEO of HUTCHMED, and wish him great success in this well-deserved appointment. I would also like to extend our deepest appreciation to Christian for his contributions and wish him the best in his retirement."

The change to the position of CEO will take effect on March 4, 2022. Also effective from the same date, Mr. Hogg will cease to be a member of the Sustainability Committee and the Technical Committee of the Company.

Mr. Hogg has confirmed that he has no disagreement with the Board, and that there are no other matters that need to be brought to the attention of the shareholders of the Company in connection with his retirement.

Further information about Dr. Su and his appointment
Dr. Su does not have any relationship with any other Directors, senior management, substantial or controlling shareholders of the Company. As at the date of this announcement, Dr. Su had a personal interest in 6,833,580 ordinary shares in the Company ("Shares"), representing approximately 0.79% of the number of Shares in issue, within the meaning of Part XV of the Securities and Futures Ordinance. The term of Dr. Su’s service as an Executive Director of the Company is subject to retirement by rotation and re-election at the annual general meeting of the Company. The director’s fees of Dr. Su as an Executive Director and a member of the Technical Committee of the Company under his appointment letter are US$70,000 and US$5,000 per annum respectively. The emoluments specified in the service agreement appointing Dr. Su as CEO and CSO of the Company are US$1,959,300 per annum in salary and cash bonus. There will also be equity compensation of up to US$4,440,700 per annum, including performance based and non-performance based portions. Such emoluments are determined by reference to the performance and profitability of the Company as well as his personal performance, remuneration benchmark in the industry and the prevailing market conditions. Such amounts are subject to review from time to time and proration for an incomplete year of service.

There are no other matters concerning Dr. Su that are required to be brought to the attention of the shareholders, nor is there other information that is required to be disclosed pursuant to the requirements of Rule 13.51(2) of the Rules Governing the Listing of Securities on the Stock Exchange of Hong Kong Limited and Rule 17 of the AIM Rules for Companies.