VBL Therapeutics to Participate in the Guggenheim Oncology Conference and the 2022 BIO CEO & Investor Conference

On February 2, 2022 VBL Therapeutics (Nasdaq: VBLT), a late-clinical stage biotechnology company developing first-in-class therapeutics for difficult-to-treat malignant solid tumors and immune or inflammatory indications, reported that Dror Harats, M.D., Chief Executive Officer of VBL Therapeutics, will participate in a fireside chat at the Guggenheim Oncology Conference being held virtually on February 9 – 11, 2022 (Press release, VBL Therapeutics, FEB 2, 2022, View Source [SID1234607610]). Management will also attend the BIO CEO & Investor Conference being held as a hybrid event on February 14 – 17, 2022.

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Guggenheim Oncology Virtual Conference
Date: Thursday, February 10, 2022
Time: 10:00 a.m. ET
Format: Fireside Chat
Webcast: View Source

2022 BIO CEO & Investor Conference
Date: February 14 – 17
Registration details for investor meetings and the event can be found here.

A link to the webcast will also be available on the Events and Presentations page of the Investor Relations section on the Company’s website at www.vblrx.com.

Fate Therapeutics to Present at Upcoming February Investor Conferences

On February 2, 2022 Fate Therapeutics, Inc. (the "Company" or "Fate Therapeutics") (NASDAQ: FATE), a clinical-stage biopharmaceutical company dedicated to the development of programmed cellular immunotherapies for patients with cancer, reported that the Company will present at the following upcoming investor conferences (Press release, Fate Therapeutics, FEB 2, 2022, View Source [SID1234607609]):

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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4th Annual Guggenheim Oncology Day available on demand on Wednesday, February 9, 2022 at 11:00 AM ET
SVB Leerink 2022 Global Healthcare Conference on demand on Wednesday, February 16, 2022 at 3:00 PM ET
A live webcast, if recorded, of each presentation can be accessed under "Events & Presentations" in the Investors section of the Company’s website at www.fatetherapeutics.com. The archived webcast will be available on the Company’s website shortly after the event.

LEIDOS TO PARTICIPATE IN THE COWEN 43RD ANNUAL AEROSPACE/DEFENSE & INDUSTRIALS CONFERENCE

On February 2, 2022 Leidos (NYSE: LDOS), a FORTUNE 500 science and technology company, reported that it will participate in the Cowen 43rd Annual Aerospace/Defense & Industrials Conference webcast (Press release, Leidos, FEB 2, 2022, View Source;INDUSTRIALS-CONFERENCE/default.aspx [SID1234607608]).

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Roger Krone, Chief Executive Officer, will participate in a question and answer "fireside chat" on Tuesday, Feb. 8, 2022 at 1:30pm ET.

A live audio webcast of the event will be available on the Leidos Investor Relations website at View Source A replay of the webcast will be available following the presentation at the same link listed above for 90 days afterward.

SHINE Europe B.V. Designing Advanced Medical Isotopes Facility in the Netherlands

On February 2, 2022 SHINE Europe B.V. (SHINE Europe), a subsidiary of SHINE Technologies, LLC, (SHINE), a next-generation nuclear technology company, reported the company has secured funding to begin designing an advanced medical isotopes facility in Veendam, the Netherlands (Press release, Shine Medical Technologies, FEB 2, 2022, View Source [SID1234607602]). This new facility will leverage SHINE’s innovative production systems to safely produce medical isotopes including molybdenum-99 (Mo-99), which is currently used in millions of diagnostic imaging procedures each year to help diagnose various life-threatening diseases in patients across the globe. The new facility is expected to develop medical isotopes in a very reliable, environmentally-friendly and less wasteful process than the legacy methods, also without adding exponential taxpayer burden to construct new European reactors.

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"Once operational, SHINE Europe demonstrates an innovative EU initiative that delivers critical medical care through new technology," said Greg Piefer, SHINE founder and CEO. "It’s like comparing travel in Mercedes-Benz’s first gasoline-powered car in the 1880s to an innovative journey inside today’s Tesla. Simply, we believe our technology will provide a state-of-the art solution for producing medical isotopes. We believe that in just a few years, and with a significant portion of investment from private funding, SHINE Europe will be providing critical Mo-99 for millions of European patients without dependency on aging reactors."

SHINE Europe marks the second such nuclear facility for the company as SHINE’s Janesville, Wis (U.S.A.) plant also plans to begin the production of Mo-99. SHINE is also exploring potential production of additional isotopes such as iodine-131 and xenon-133, among others. Once SHINE Europe is fully operational, SHINE anticipates the two facilities’ combined output of Mo-99 can serve up to 70 percent of the global need for Mo-99 used in daily diagnostic imaging.

The current phase of SHINE’s European project is being funded by the Province of Groningen, and the Federal State of the Netherlands. SHINE’s other investors include leading global private and public entities such as Baillie Gifford, Koch Disruptive Technologies, Fidelity, Deerfield Management Company, and Oaktree Capital Management.

"We are very pleased to see this breakthrough technology in nuclear medicine coming to the Province of Groningen in the Netherlands, and especially with a cause to help so many Europeans with critical diagnostic procedures," said Commissioner of the King, René Paas. "SHINE Europe is a great community partner helping to bring global innovation and technology to Veendam."

The supply of Mo-99 to support millions of diagnostic imaging procedures continues to be a challenge. SHINE Europe’s innovative approach demonstrates an efficient path to help solve this challenge.

"Europe has consistently struggled with unstable, aging reactors leading to supply issues and shortages of Mo-99," said Harrie Buurlage, SHINE’ General Manager of European Operations. "We believe the SHINE Europe facility will greatly improve the supply chain, reduce potential shortages of various fission-based isotopes, and empower medical professionals to deliver a higher level of patient care. Delivering Mo-99 for millions of diagnostic procedures across Europe and beyond is at the core of SHINE’s efforts."

"We are delighted about the company’s plans to build another advanced facility, providing additional capacity and reliable consistent supply of critical diagnostic and therapeutic isotopes. This will help medical professionals caring for tens of thousands of heart and cancer patients every day across the globe" said Julia Casey, General Manager – Molecular Imaging of GE Healthcare, based in Europe.

Scandion Oncology expands clinical development with internationalization of the CORIST-trial

On February 2, 2022 Scandion Oncology reported that The CORIST phase II-trial studying Scandion Oncology’s lead compound SCO-101 as combination therapy in patients with metastatic colorectal cancer is now approved to recruit patients in Germany and Spain in addition to Denmark (Press release, Scandion Oncology, FEB 2, 2022, View Source,c3496820 [SID1234607601]).

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Scandion Oncology (Scandion), a biotech company developing first-in-class medicines aimed at treating cancer which is resistant to current treatment options, now further upscales its efforts in clinical development by expanding the ongoing CORIST phase II-trial with its lead compound SCO-101 to also include patients in Germany and Spain.

The Federal Institute for Drugs and Medical Devices (BfArM) and The Spanish Agency of Medicines and Medical Devices (AEMPS) as well as the local German and Spanish ethical committees have now given the approval for the trial to be conducted, and Scandion will activate clinical sites in these countries shortly.

The approvals mark the beginning of the planned internationalization of the CORIST-trial, which has so far recruited patients in Denmark, and is now expanded to other countries. This is expected to support recruitment of patients to the trial, which is scheduled to conclude in the second or third quarter of 2022.

The expansion of the CORIST-trial, which studies SCO-101 as combination therapy in patients with metastatic colorectal cancer, follows the earlier internationalization of the PANTAX phase Ib-trial, which studies SCO-101 in patients with unresectable or metastatic pancreatic cancer.

Both expansions show how Scandion is scaling up its efforts in clinical development as the company is building capabilities to conduct clinical trials in all relevant countries, including the US, as well as conducting randomized pivotal trials going forward. This will enable Scandion to carry through full clinical development of its potential new first in class medicines. Further, the internationalization of the CORIST-trial will help increase the awareness of SCO-101 with authorities and leading international investigators.

"We are pleased to expand the CORIST-trial and further enhance our capabilities to conduct clinical trials internationally. It is a corner stone of our strategy to build the capacity to carry through full clinical development. This will allow us to pursue co-development partnerships or independently develop our molecules depending on how we can best create maximum value for patients, caregivers, the company and its owners", says Bo Rode Hansen, President & CEO of Scandion.

About the CORIST phase II-trial

The trial investigates SCO-101 as combination therapy in patients with metastatic colorectal cancer. On June 24, 2021, Scandion reported positive results from the dose-finding part 1 of the trial. A well tolerated dose of SCO-101 in combination with the chemotherapy regimen FOLFIRI was determined and the treatment resulted in notable potentiation of FOLFIRI. Scandion Oncology also identified the oncogene RAS as a predictive biomarker, which led the company to making an amendment to the clinical protocol, optimizing the inclusion of patients and de-risking the study.

The design for the ongoing part 2 of the trial (the proof-of-concept arm) is a standard single arm phase II-trial with the aim of assessing preliminary effect and further evaluating safety and tolerability of SCO-101 in combination with FOLFIRI. The primary efficacy objective is assessment of response (tumor reduction) and secondary objectives include assessment of Clinical benefit (the duration of Stable Disease, Progression Free Survival (PFS), Overall Survival (OS)) as well as biomarker assessment and correlation to treatment tolerability and outcome. Part 2 of the CORIST phase II-trial is planned to include 25 patients.