On February 28, 2022 MaaT Pharma (EURONEXT: MAAT – the "Company"), a French clinical-stage biotech and a pioneer in the development of microbiome-based ecosystem therapies dedicated to improving survival outcomes for patients with cancer reported its cash position as of December 31, 2021, and its full-year 2021 revenues (Press release, MaaT Pharma, FEB 28, 2022, View Source [SID1234609135]).

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"2021 has been an eventful year for MaaT Pharma. Promising results from our Phase 2 and from the Early Access Program for MaaT013, our lead candidate ready to enter a Phase 3 study, marked our clinical development. We also reached a new milestone in our history in 2021 with the success of our IPO on the Euronext, which allowed us to raise EUR 35.7 million. We are in a solid financial position and are moving forward in our development with value-creating clinical milestones expected in the upcoming months for MaaT013 and our second drug candidate, MaaT033, as well as scaling up our manufacturing capacities," stated Hervé Affagard, CEO and co-founder of MaaT Pharma.

Cash position1
As of December 31, 2021, total cash and cash equivalents were EUR 43.3 million, as compared to EUR 19.9 million as of December 31, 2020. The increase in cash flow is due to the capital raise of EUR 35.7 million following the Company’s IPO on Euronext on November 8, 2021. The Company believes it has sufficient cash to cover needs of the development programs presented during the IPO up until the end of the third quarter of 2023.

Revenues in 20211
MaaT Pharma reported revenues of EUR 1.0 million for the year ended December 31, 2021, which includes compensation from the Temporary Authorization for Use program (ATUn), known as compassionate access program since July 1, 2021, and approved by the French National Drug Safety Agency (Agence Nationale de Sécurité du Médicament or ANSM). In 2021, new patients, mostly suffering from graft-versus-host disease, were granted early access treatment with MaaT013. To date in 2022, requests for the early access program are following as similar trend to that observed in 2021.

Upcoming financial communication and investor conference participation
March 3, 2022 (10:00am CET) – Ordinary and Extraordinary Shareholders’ General Meeting (regarding resolutions relative to the implementation of a Liquidity Contract, the Annual General meeting will take place at a later date).
April 15, 2022 – Annual results 2021
April 20 and 21, 2022 – 14th Kempen Life Sciences Conference, Amsterdam
June 29 and 30, 2022 – 9th Portzamparc Annual conference, Paris

On February 28, 2022 Kura Oncology, Inc. (Nasdaq: KURA), a clinical-stage biopharmaceutical company committed to realizing the promise of precision medicines for the treatment of cancer, reported that Troy Wilson, Ph.D., J.D., President and Chief Executive Officer, is scheduled to participate in two upcoming investor conferences (Press release, Kura Oncology, FEB 28, 2022, View Source [SID1234609134]):

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A "Leukemias/MPN" panel discussion at the virtual Cowen 42nd Annual Health Care Conference at 10:30 a.m. ET / 7:30 a.m. PT on March 7, 2022; and

A podium/fireside chat at the Barclays Global Healthcare Conference in Miami at 11:15 a.m. ET / 8:15 a.m. PT on March 15, 2022.
Audio webcasts will be available in the Investors section of Kura’s website at www.kuraoncology.com, with archived replays available following both events.

On February 28, 2022 Kinnate Biopharma Inc. (Nasdaq: KNTE) ("Kinnate"), a biopharmaceutical company focused on the discovery and development of small molecule kinase inhibitors for difficult-to-treat, genomically defined cancers, reported that its Chief Executive Officer Nima Farzan will provide a company overview at the 42nd Annual Cowen Health Care Conference, being held virtually from March 7-9, 2022 (Press release, Kinnate Biopharma, FEB 28, 2022, View Source [SID1234609133]).

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Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Event: 42nd Annual Cowen Health Care Conference
Location: Virtual
Date: Wednesday, March 9, 2022
Time: 1:30 PM ET/10:30 AM PT

Members of the Kinnate management team will also host investor meetings during the conference.

A live webcast of the Cowen presentation will be available in the Investors and Media section of the Kinnate website at www.kinnate.com. A webcast replay will also be available on this website shortly after conclusion of the event for 30 days.

On February 28, 2022 Jounce Therapeutics, Inc. (NASDAQ: JNCE), a clinical-stage company focused on the discovery and development of novel cancer immunotherapies and predictive biomarkers, reported that Jounce management will participate in a novel immuno-oncology panel discussion at the Cowen & Co. 42nd Annual Health Care Conference on Monday, March 7, 2022 at 10:30 a.m. ET (Press release, Jounce Therapeutics, FEB 28, 2022, View Source [SID1234609132]).

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Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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A webcast of the panel will be available by visiting "Events and Presentations" in the Investors and Media section of Jounce’s website at www.jouncetx.com. A replay of the webcasts will be archived for 30 days following the presentation.

On February 28, 2022 Inhibrx, Inc. (Nasdaq: INBX), a biotechnology company with four clinical programs in development and a strong emerging pipeline, reported financial results for the fourth quarter and fiscal year 2021 and provided an update on recent corporate highlights (Press release, Inhibrx, FEB 28, 2022, View Source [SID1234609131]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Recent Corporate Highlights

On December 1, 2021, Inhibrx announced that the FDA has granted orphan-drug designation for INBRX-109 for the treatment of conventional chondrosarcoma.
On January 4, 2022, Inhibrx announced initial Phase 1 dose escalation results for INBRX-106, a novel hexavalent OX40 agonist, in combination with Keytruda (Pembrolizumab), which was observed to be well tolerated with predominantly mild or moderate immune-related toxicities noted. Inhibrx expects to announce initial data from the dose expansion cohorts in combination with Keytruda during the second half of 2022.
On February 22, 2022, Inhibrx announced that it had entered into an amendment to its Loan and Security Agreement with Oxford Finance LLC. The amendment provides for the funding of an additional $130.0 million in gross proceeds, $40.0 million of which was funded upon execution of the amendment on February 18, 2022, with the remaining $90.0 million to be funded in three separate tranches upon future milestone events.
Financial Results

Cash and Cash Equivalents. As of December 31, 2021, Inhibrx had cash and cash equivalents of $131.3 million, compared to $128.7 million as of December 31, 2020. Cash and cash equivalents totaled $152.8 million as of February 21, 2022.
R&D Expense. Research and development expenses were $18.6 million during the fourth quarter of 2021, compared to $17.7 million during the fourth quarter of 2020. Research and development expenses were $71.4 million during the fiscal year 2021, compared to $73.5 million during the fiscal year 2020. During the fiscal year 2021, Inhibrx incurred increased clinical trial expenses following the initiation of a Phase 2 trial in conventional chondrosarcoma and the progression of ongoing Phase 1 trials, while contract development and manufacturing expenses decreased due to the timing of work performed by Inhibrx’s partners during 2020 in relation to the formulation and manufacturing of certain of its therapeutic candidates. Personnel-related costs increased during fiscal year 2021 as a result of the continued expansion of the organization.
G&A Expense. General and administrative expenses were $3.6 million during the fourth quarter of 2021, compared to $2.2 million during the fourth quarter of 2020. General and administrative expenses were $12.4 million during the fiscal year 2021, compared to $6.8 million during the fiscal year 2020. These increases were primarily driven by increases in personnel-related costs, as well as increases in professional service fees related to Inhibrx’s expanding intellectual property portfolio and other expenses associated with operating as a public company following its initial public offering in August 2020.
Net Loss. Net loss was $21.2 million during the fourth quarter of 2021, or $0.55 per share, compared to $17.6 million during the fourth quarter of 2020, or $0.47 per share. Net loss was $81.8 million during the fiscal year 2021, or $2.15 per share, compared to $76.1 million during the fiscal year 2020, or $3.01 per share.
About the Inhibrx sdAb Platform
Inhibrx utilizes diverse methods of protein engineering in the construction of therapeutic candidates that can address the specific requirements of complex target and disease biology. A key tool for this effort is the Inhibrx proprietary sdAb platform, which enables the development of therapeutic candidates with attributes superior to other monoclonal antibody and fusion protein approaches. This platform allows the combination of multiple binding units in a single molecule, enabling the creation of therapeutic candidates with defined valency or multiple specificities that can achieve enhanced cell signaling or conditional activation. An additional benefit of this platform is that these optimized, multi-functional entities can be manufactured using the established processes that are commonly used to produce therapeutic proteins.