Onxeo appoints Julien Miara as new interim CEO

On January 3, 2022 Onxeo S.A. (Euronext Growth Paris: ALONX, First North Copenhagen: ONXEO), ("Onxeo" or "the Company"), a clinical-stage biotechnology company specializing in the development of innovative drugs targeting tumor DNA Damage response (DDR), reported the appointment of Julien Miara as interim Chief Executive Officer, effective January 3rd, 2022, following approval from the Board of Directors (Press release, Onxeo, JAN 3, 2022, View Source [SID1234597960]).

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Julien Miara is a Principal at Invus SAS, the independent adviser to Invus Public Equities, L.P. He is also member of the Board of Directors of Onxeo. He has more than 10 years of experience in Finance and biotechnology. Julien Miara will work closely with Dr. Shefali Agarwal, Chairwoman of the Board of Directors who has extensive experience in drug development, to ensure that the company is progressing according to the strategic plan laid out by the Board of Directors and prepare for a successful transition to the next CEO.

The company’s Board of Directors is actively working on recruiting Onxeo’s next CEO who will focus on bringing expeditiously AsiDNA to the patients to respond to their high unmet medical need, develop the rich pre-clinical pipeline such as OX401 and provide Onxeo with international visibility.

Dr. Agarwal said: "I look forward to working with the high performing team under the supervision of Julien Miara, in the next phase of research and development for AsiDNA. I believe that Onxeo’s scientific vision and approach will drive the continued success of the company, as we work together to deliver promising new options for patients"

MaaT Pharma to Present at H.C. Wainwright BioConnect 2022 Virtual Conference

On January 3, 2022 MaaT Pharma (EURONEXT: MAAT – the "Company"), a French clinical-stage biotech and a pioneer in the development of microbiome-based ecosystem therapies dedicated to improving survival outcomes for patients with cancer, reported that its CEO and co-founder, Hervé Affagard will present the company at the upcoming H.C. Wainwright Bioconnect Virtual Conference held January 10-13, 2022 (Press release, MaaT Pharma, JAN 3, 2022, View Source [SID1234597959]).

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The presentation will be available on-demand through the H.C. Wainwright conference portal, starting at 7 am EST/1:00 pm CET on Monday, January 10, 2022.

A replay of the presentation will also be made accessible in the investors’ section of the company’s website at www.maatpharma.com from Friday, January 14, 2022 and for 90 days after the event.

Entry into a Material Definitive Agreement

On January 3, 2022, Kinnate Biopharma Inc. (the "Company") reported that entered into a sales agreement (the "Sales Agreement") with SVB Leerink LLC ("SVB Leerink"), pursuant to which the Company may offer and sell shares of the Company’s common stock, par value $0.0001 per share, from time to time, through an "at the market offering" program under which SVB Leerink will act as sales agent (Filing, 8-K, Kinnate Biopharma, JAN 3, 2022, View Source [SID1234597958]). Pursuant to the sales agreement prospectus supplement included in the Company’s Form S-3 filed on January 3, 2022, the Company may offer and sell common stock having aggregate gross sales proceeds of up to $150 million.

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Under the Sales Agreement, the Company will set the parameters for the sale of shares, including the number or dollar value of shares to be issued, the time period during which sales are requested to be made, limitation on the number of shares that may be sold in any one trading day and any minimum price below which sales may not be made. Subject to the terms and conditions of the Sales Agreement, SVB Leerink may sell the shares by methods deemed to be an "at the market offering" as defined in Rule 415(a)(4) promulgated under the Securities Act of 1933, as amended (the "Securities Act"). SVB Leerink will use commercially reasonable efforts in conducting such sales activities consistent with its normal trading and sales practices, on mutually agreed terms between SVB Leerink and the Company. The Company is not obligated to sell, and SVB Leerink is not obligated to sell, any shares of common stock under the Sales Agreement. No assurance can be given that the Company will sell any shares of common stock under the Sales Agreement, or, if it does, as to the price or amount of shares of common stock that it sells or the dates when such sales will take place. The Sales Agreement may be terminated by either party by giving ten trading days’ prior written notice to the other party for any reason, subject to further qualifications as described in the Sales Agreement.

The Sales Agreement provides that SVB Leerink will be entitled to compensation for its services equal to up to 3.0% of the gross proceeds of any shares sold through SVB Leerink under the Sales Agreement. SVB Leerink and the Company have no obligation to sell any shares under the Sales Agreement and may at any time, upon notice to the other party, suspend solicitation and offers under the Sales Agreement.

In the Sales Agreement, the Company has agreed to indemnify SVB Leerink against certain liabilities, including under the Securities Act and to contribute payments that SVB Leerink may be required to make because of such liabilities. Further, SVB Leerink agreed to indemnify the Company, the Company’s board of directors and its executive officers against certain liabilities, including under the Securities Act.

The shares of common stock sold pursuant to the Sales Agreement will be issued pursuant to the Company’s shelf registration statement on Form S-3, including the prospectus supplement contained therein, filed with the Securities and Exchange Commission (the "SEC") on January 3, 2022, which was automatically effective upon filing with the SEC.

The foregoing description of the Sales Agreement is not complete and is qualified in its entirety by reference to the full text of such agreement, a copy of which is filed herewith as Exhibit 1.1 to this Current Report on Form 8-K and is incorporated herein by reference.

This Current Report on Form 8-K shall not constitute an offer to sell or the solicitation of an offer to buy the securities discussed herein, nor shall there be any sale of such securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Myovant Sciences to Present at the 40th Annual J.P. Morgan Healthcare Conference

On January 3, 2022 Myovant Sciences (NYSE: MYOV), a healthcare company focused on redefining care for women and for men, reported that David Marek, Chief Executive Officer of Myovant Sciences, Inc., will present at the 40th Annual J.P. Morgan Healthcare Conference on Wednesday, January 12, 2022 at 3:00 p.m. Eastern Time (Press release, Myovant Sciences, JAN 3, 2022, https://investors.myovant.com/news-releases/news-release-details/myovant-sciences-present-40th-annual-jp-morgan-healthcare [SID1234597957]).

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Investors and the general public are invited to listen to the presentation, which will be accessible on the Events page under the Investors & Media section of the Myovant website at www.myovant.com.

U.S. Food and Drug Administration Approves Immix Biopharma Rare Pediatric Disease Designation for IMX-110 as a Treatment for Life-Threatening Pediatric Cancer in Children

On January 3, 2021 Immix Biopharma, Inc. (Nasdaq: IMMX) ("ImmixBio" or the "Company"), a biopharmaceutical company pioneering Tissue-Specific Therapeutics (TSTx)TM targeting oncology and immuno-dysregulated diseases, reported that the U.S. Food and Drug Administration (FDA) has granted Rare Pediatric Disease (RPD) designation for IMX-110 for the treatment of a life-threatening form of pediatric cancer in children, rhabdomyosarcoma. IMX-110, an investigational product, is currently being evaluated in a Phase 1b/2a clinical trial (Press release, Immix Biopharma, JAN 3, 2022, View Source [SID1234597956]).

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The FDA grants Rare Pediatric Disease designation for serious and life-threatening diseases that primarily affect children aged 18 years or younger and impact fewer than 200,000 people in the United States.

If a New Drug Application in the United States for IMX-110 is approved, ImmixBio may be eligible to receive a Priority Review Voucher (PRV) from the FDA, which can be redeemed to obtain priority review for any subsequent marketing application, or may be sold or transferred.

"We are pleased by FDA’s acknowledgment of the urgent need for a safe and effective treatment for children with this devastating disease," stated ImmixBio’s Chief Executive Officer Ilya Rachman, M.D., PhD. "We are encouraged by our Phase 1b/2a clinical data in soft tissue sarcoma. IMX-110 is a tissue-specific therapeutic that simultaneously attacks all 3 components of the tumor micro-environment, severing the critical lifelines between the tumor and its metabolic and structural support. We believe our SMARxT platform generating Tissue-Specific Therapeutics represents a distinct alternative to the traditional ‘single target, single mutation’ development model."

Rhabdomyosarcoma ("RMS") is a high-grade, malignant neoplasm, the most common soft tissue sarcoma in pediatric and adolescent populations and which rarely occurs in adults. The prevalence of RMS in the United States is approximately 20,000 children of all ages. The five-year survival rate ranges from 20% to 30% for children in the high-risk group where cancer spreads widely in the body.

IMX-110 is the first clinical-stage product of ImmixBio’s SMARxT Tissue-Specific Platform, which produces Tissue-Specific Therapeutics that accumulate at intended therapeutic sites at 3 to 5 times the rate of conventional medicines. The FDA has already granted orphan drug designation (ODD) to IMX-110 for the treatment of soft tissue sarcoma.

ImmixBio recently shared clinical data across multiple soft tissue sarcoma subtypes in several heavily pretreated patients demonstrating median progression-free survival (PFS) of 4 months with zero drug-related severe adverse events and zero dose interruptions due to toxicity. The data can be viewed in the Immix Biopharma Corporate Presentation at View Source