Day One to Present at the 40th Annual J.P. Morgan Healthcare Conference

On January 5, 2022 Day One Biopharmaceuticals (Nasdaq: DAWN), a clinical-stage biopharmaceutical company dedicated to developing and commercializing targeted therapies for people of all ages with life-threatening diseases, reported that Dr. Jeremy Bender, chief executive officer, will present virtually during the 40th Annual J.P. Morgan Healthcare Conference on Tuesday, January 11 at 10:30 a.m. ET (Press release, Day One, JAN 5, 2022, View Source [SID1234598211]).

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A live audio webcast of the presentation will be available by visiting the Events & Presentations section of the Company’s website. An archived replay of the webcast will be available for 30 days following the live presentation.

CytomX Therapeutics to Present at the 40th Annual J.P. Morgan Healthcare Conference

On January 5, 2022 CytomX Therapeutics, Inc. (Nasdaq: CTMX), a leader in the field of conditionally activated therapeutics, reported that Sean McCarthy, D.Phil., president, chief executive officer, and chairman, will present virtually at the 40th Annual J.P. Morgan Healthcare Conference on Wednesday, January 12th at 3:00 p.m. ET (Press release, CytomX Therapeutics, JAN 5, 2022, View Source [SID1234598210]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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A live webcast of the presentation will be available on the Events and Presentations page of CytomX’s website at www.cytomx.com. An archived replay will be available for 30 days following the event. In addition, management will be available for one-on-one meetings with investors who are registered to attend the conference.

Cogent Biosciences Provides 2022 Corporate Guidance

On January 5, 2021 Cogent Biosciences, Inc. (Nasdaq: COGT), a biotechnology company focused on developing precision therapies for genetically defined diseases, reported that provided 2021 year-end updates and corporate guidance for 2022 (Press release, Cogent Biosciences, JAN 5, 2022, View Source [SID1234598209]).

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"I am proud of the substantial progress the Cogent team made in 2021. In addition to achieving our key corporate milestones of initiating three late-stage clinical trials of bezuclastinib, our highly potent and selective KIT mutant inhibitor, we also formed the Cogent Research Team which is focused on building a portfolio of best-in-class small molecules for patients with significant unmet medical need," said Andrew Robbins, President and CEO of Cogent Biosciences. "In 2022, we will advance the APEX, SUMMIT and PEAK clinical trials, with preliminary clinical data expected from APEX in the first half of 2022. In addition, we look forward to moving into our new research headquarters in Boulder and to sharing more details about the impressive research pipeline the Cogent Research Team has created in a very short period of time."

Key Highlights

Bezuclastinib now under investigation in three late-stage clinical trials
APEX clinical trial in patients with Advanced Systemic Mastocytosis (AdvSM): In mid-2021, Cogent initiated APEX, a Phase 2 clinical study of bezuclastinib in patients with AdvSM. APEX is an open-label, global, multicenter study evaluating the safety, efficacy, pharmacokinetic, and pharmacodynamic profiles of bezuclastinib. We expect to report preliminary clinical data at a scientific conference during the first half of 2022, including safety and tolerability data as well as bezuclastinib’s impact on serum tryptase levels, a validated biomarker of mast cell activity. Learn more about the APEX trial at cogentclinicaltrials.com/apex/.
SUMMIT clinical trial in patients with Nonadvanced Systemic Mastocytosis (NonAdvSM): In the fall of 2021, Cogent initiated SUMMIT, a randomized, double-blind, placebo-controlled, global Phase 2 clinical trial. The study is designed to explore the safety and efficacy of bezuclastinib in patients with moderate to severe Indolent Systemic Mastocytosis (ISM) or Smoldering Systemic Mastocytosis (SSM). Learn more about the SUMMIT trial at cogentclinicaltrials.com/summit/.
PEAK clinical trial in patients with Gastrointestinal Stromal Tumors (GIST): During the fourth quarter of 2021, Cogent initiated PEAK, a randomized, open-label, global Phase 3 clinical trial. The PEAK study is designed to explore the efficacy of bezuclastinib in combination with sunitinib compared to sunitinib alone in patients with locally advanced, unresectable or metastatic GIST who have received prior treatment with imatinib.

Preclinical data highlights bezuclastinib as potent KIT inhibitor with minimal CNS activity and PDGFR inhibition
During the third quarter of 2021, Cogent presented preclinical data providing further evidence of bezuclastinib as a differentiated, potent, and selective KIT mutant inhibitor with minimal brain penetration that avoids targeting PDGFR isoforms. These data were presented in a virtual poster at the 2021 AACR (Free AACR Whitepaper)-NCI-EORTC Virtual AACR-NCI-EORTC (Free AACR-NCI-EORTC Whitepaper) International Conference on Molecular Targets and Cancer Therapeutics (EORTC-NCI-AACR) (Free ASGCT Whitepaper) (Free EORTC-NCI-AACR Whitepaper).

Cogent Research Team created to generate robust pipeline of potential best-in-class molecules
Cogent Research Team: During the second quarter of 2021, the company announced the formation of its Cogent Research Team, a highly-experienced, Boulder-based discovery and research team focused on pioneering best-in-class, small molecule therapeutics to expand Cogent’s pipeline.
The Cogent Research Team is led by John Robinson, PhD, and already has grown to over 35 employees. This spring, the team will move into its newly-built, state-of-the-art research facility in Boulder.
Cogent Scientific Advisory Board: In mid-2021, the company formed the Cogent Scientific Advisory Board, which is comprised of world-class experts involved in the discovery and development of novel therapeutics for patients with genetically driven diseases. This group has been brought together to provide external perspective for the Cogent Research Team as it develops a robust portfolio of novel, small molecule discovery programs designed to address significant patient unmet needs.
R&D Investor Event: In April 2022, Cogent will host an R&D investor event to introduce the Cogent Research Team, outline its strategy and focus to create best-in-class small molecules, highlight additional preclinical data demonstrating the potential differentiated profile for bezuclastinib and present early data from its growing pipeline of novel, small molecule targeted therapy programs.

Blueprint Medicines Announces CEO and Leadership Transition Plan

On January 5, 2022 Blueprint Medicines Corporation (NASDAQ: BPMC) reported that its Board of Directors has appointed Kate Haviland to succeed Jeff Albers as Chief Executive Officer (CEO), effective April 4, 2022 (Press release, Blueprint Medicines, JAN 5, 2022, View Source [SID1234598208]). At that time, Mr. Albers will transition from his current role as Chairman, President and CEO to Executive Chairman of the Board of Directors and Ms. Haviland will transition from her current role as Chief Operating Officer (COO) to President and CEO. In addition, Ms. Haviland will be appointed to serve on the company’s Board of Directors, effective April 4, 2022.

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Blueprint Medicines also announced today that Christina Rossi has been promoted from Chief Commercial Officer to COO. In her new role, Ms. Rossi will retain leadership of global commercial strategy and operations, and expand her oversight to include portfolio strategy and program management, corporate development, and corporate affairs, effective April 4, 2022.

"Serving as CEO of Blueprint Medicines for the last eight years has been the highlight of my career, and I’m immensely proud of all that we’ve accomplished in our efforts to improve and extend the lives of patients," said Jeff Albers, Chairman, President and CEO of Blueprint Medicines. "Today, Blueprint Medicines is a fully integrated, global company delivering approved medicines to patients around the world. With a foundation of R&D and commercial success and an exciting pipeline of therapeutic candidates positioned to drive the company’s next phase of transformational growth, it is the right time for me to transition leadership to Kate and our outstanding executive team."

Mr. Albers continued, "I have known Kate for nearly two decades and have valued her expertise and leadership throughout our time working together at Blueprint Medicines. Since joining the company six years ago, Kate has touched all aspects of our business and has been a steadfast partner in charting the company’s course through both successes and setbacks. She is adept at identifying and pursuing opportunities for growth and managing resource allocations across our broad portfolio, while also driving a high-performance culture anchored in transparency and a commitment to a diverse and inclusive workforce."

"The Board’s selection of Kate as our next CEO is the culmination of a thoughtful, long-term succession planning process that was led by Jeff and the Board and purposefully designed to drive the company’s continued success, ensure continuity, and empower our strong executive team. Kate is an exceptional leader with a clear and inspiring vision, demonstrated ability to lead and execute an integrated business strategy, and deep commitment to our patient-centric mission and culture of innovation. The Board is confident in her ability to lead the company to reach its full potential through our next phase of growth and beyond," said Alexis Borisy, co-founder and member of the Board of Directors of Blueprint Medicines. "On behalf of the Board, I want to thank Jeff for his remarkable leadership as CEO. During his tenure, the company has achieved tremendous success, developing from a privately held preclinical enterprise into a leading independent precision therapy company. It has been a privilege to be part of the company’s exponential growth, and I look forward to working with Kate and Jeff as the company continues to deliver important, innovative medicines to patients globally."

"I am excited to become CEO of Blueprint Medicines as we build on our success by advancing the ongoing commercial launch of AYVAKIT (avapritinib) in advanced systemic mastocytosis, achieving a constellation of near-term clinical data milestones for multiple therapeutic candidates, and expanding our portfolio with promising new research programs that we believe will drive substantial growth over the long term," said Kate Haviland. "Blueprint Medicines was founded with a vision to change the lives of patients who have received a devastating diagnosis of cancer or hematologic disease. I have been honored to be a part of the team that has made this vision a reality. Over the years, I have met many patients and families whose lives have been impacted and extended by our efforts. I am driven by these experiences to expand the impact Blueprint Medicines can have on more people and families across the globe who are looking to us with hope for a better future. I look forward to continuing to work with Jeff, as he steps into the Executive Chairman role, the Board, and our executive team. Most importantly, I’m thrilled to lead and work side-by-side with our employees at Blueprint Medicines, a team that is passionate and deeply committed to continuously driving and delivering medical innovation."

Ms. Haviland joined Blueprint Medicines in January 2016 as Chief Business Officer and has served as Chief Operating Officer since January 2019. Over this time, she served as the founding chair of the portfolio management team, formed and executed business development strategy, drove global capital investment plans, and played a key role in capital market financings. In addition, she directly supported the company’s evolution into a fully integrated business by developing and providing ongoing management of critical functions, including portfolio strategy and program management, corporate development, commercial strategy, international, technical operations, corporate affairs, and information systems. Prior to joining Blueprint Medicines, Ms. Haviland held leadership roles focused on building emerging, high-growth companies and advancing the development of innovative therapies in oncology and rare diseases as Vice President, Rare Diseases and Oncology Program Leadership at Idera Pharmaceuticals, Head of Commercial Development at Sarepta Therapeutics, Executive Director of Commercial Development at PTC Therapeutics, and roles in both corporate development and project management at Genzyme. She holds a B.A. from Wesleyan University with a double major in Biochemistry/Molecular Biology and Economics and an M.B.A. from Harvard Business School. Ms. Haviland has served as an independent director on the board of Fulcrum Therapeutics since June 2018 and is a member of the audit and compensation committees.

As part of the succession plan, Mr. Albers has agreed to serve as Executive Chairman through the end of 2022, with continued service as Chairman thereafter, with the goal of enabling a seamless leadership transition as the company continues to execute on its growth strategy.

bluebird bio to Present at the 40th Annual J.P. Morgan Healthcare Conference

On January 5, 2022 bluebird bio, Inc. (Nasdaq: BLUE) reported that members of the management team will present at the virtual 40th Annual J.P. Morgan Healthcare Conference, Wednesday, January 12, at 3:45 p.m. ET (Press release, bluebird bio, JAN 5, 2022, View Source [SID1234598206]).

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To access the live webcast of bluebird bio’s presentation, please visit the "Events & Presentations" page within the Investors & Media section of the bluebird bio website at View Source A replay of the webcast will be available on the bluebird bio website for 30 days following the event.