TG Therapeutics to Present at the 39th Annual J.P. Morgan Healthcare Conference

On January 8, 2021 TG Therapeutics, Inc. (NASDAQ: TGTX) reported that Michael S. Weiss, the Company’s Executive Chairman and Chief Executive Officer, will present at the 39th Annual J.P. Morgan Healthcare Conference, being held virtually (Press release, TG Therapeutics, JAN 8, 2021, View Source [SID1234573706]). The presentation is scheduled to take place on Tuesday, January 12, 2021 at 2:00 PM ET.

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A live webcast of this presentation will be available on the Events page, located within the Investors & Media section, of the Company’s website at View Source A replay of the webcast will be available on TG’s website following the event.

ATP and Biolojic Design Launch Aulos Bioscience to Develop Highly Differentiated IL-2 Antibody Approach to Fighting Cancer

On January 8, 2021 ATP, a leading life sciences venture capital firm, and Biolojic Design, a biotechnology company that computationally designs functional antibodies, reported that unveiled Aulos Bioscience, a new company that is developing highly differentiated interleukin-2 (IL-2)-binding monoclonal antibodies as therapeutics against solid tumors (Press release, ATP, JAN 8, 2021, View Source [SID1234573705]). ATP has committed $40 million in Series A funding to advance Aulos’ lead molecule from preclinical stage through clinical proof of concept, with human trials expected to start later this year.

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"ATP created Aulos with Biolojic to develop antibodies with unique properties that we believe hold best-in-class promise among IL-2 targeted therapies," said Michael Ehlers, M.D., Ph.D., Chief Scientific Officer of and venture partner at ATP. "Biolojic has designed elegant and impressively simple molecules that redirect IL-2 to low-affinity effector T-cells away from high-affinity regulatory T-cells by binding to the body’s own IL-2, steering it away from immune suppression and towards immune activation. Other drug candidates that redirect IL-2 fail to target naturally occurring IL-2 and introduce complex, modified, exogenous versions of IL-2 that are often difficult to manufacture and can have unfavorable pharmacokinetic properties. We think that the advantages of the Aulos approach could enable us to deliver a new mainstay in fighting multiple cancers."

Yanay Ofran, Ph.D., Chief Executive Officer of Biolojic Design and acting CEO of Aulos Bioscience, said: "We are excited to partner with ATP to bring our unique computationally designed antibodies to patients. Biolojic’s AI-based platform designs mono- and multi-specific human antibodies that target pre-determined epitopes with exquisite precision and execute functions previously not carried out with antibodies. These capabilities are illustrated by the Aulos anti-IL-2 antibody approach, which has the potential to fully unlock the power of the patient’s own IL-2. We see Aulos as an opportunity to dramatically change the cancer treatment landscape. Moreover, we believe this will be the first ever computationally designed antibody to enter human trials."

Aulos Bioscience will be based in Cambridge, MA. The company’s Board of Directors is chaired by Dr. Ehlers and includes as members Dr. Ofran; Yechezkel Barenholz, Ph.D., Professor of Biochemistry at the Hebrew University Hadassah Medical School who is known as an innovator of therapeutic applications of liposomes and nanomedicine, notably as a co-inventor of Doxil (doxorubicin); Joseph A. Yanchik III, a venture partner at ATP and founder of companies including Aileron Therapeutics and Tokai Pharmaceuticals (now Novus Therapeutics); and Raj Chopra, FRCP, FRCPath, FRSB, Ph.D., an ATP venture partner, former director of the Cancer Research UK Cancer Therapeutics Unit at the Institute of Cancer Research in London, and co-founder of Monté Rosa Therapeutics.

Dr. Ehlers and Dr. Ofran will present more information about Aulos Bioscience at the 39th annual J.P. Morgan Healthcare Conference on Thursday, January 14, 2021. The live stream is scheduled to begin at approximately 10:25 am EST. A link to the webcast will be available on the Aulos website at aulosbio.com.

Varian Announces First Quarter Fiscal Year 2021 Earnings Release Date

On January 8, 2021 Varian (NYSE: VAR) reported its first quarter fiscal year 2021 earnings release date (Press release, Varian Medical Systems, JAN 8, 2021, View Source [SID1234573703]).

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The Company will report results for the first quarter of fiscal year 2021 after market close on Tuesday, January 26, 2021.

In light of the pending transaction with Siemens Healthineers, Varian will not be hosting a conference call for its first quarter fiscal year 2021 earnings.

For automatic e-mail alerts regarding Varian news and events, investors can subscribe on the company website: View Source

Fate Therapeutics Announces Completion of Public Offering of Common Stock and Pre-Funded Warrants, and Full Exercise of Underwriters’ Option to Purchase Additional Shares

On January 8, 2021 Fate Therapeutics, Inc. (the "Company" or "Fate Therapeutics") (NASDAQ: FATE), a clinical-stage biopharmaceutical company dedicated to the development of programmed cellular immunotherapies for cancer and immune disorders, reported the closing of an underwritten public offering of 5,122,807 shares of its common stock, which included 701,754 shares that were issued pursuant to the full exercise of the underwriters’ option to purchase additional shares, at a public offering price of $85.50 per share (Press release, Fate Therapeutics, JAN 8, 2021, View Source [SID1234573702]). In addition, in lieu of common stock to certain investors, the Company announced the closing of an underwritten public offering of pre-funded warrants to purchase 257,310 shares of its common stock at a purchase price of $85.499 per pre-funded warrant, which equals the public offering price per share of the common stock less the $0.001 exercise price per share of each pre-funded warrant. Aggregate net proceeds from this offering are expected to be approximately $432 million after deducting underwriting discounts and commissions and other estimated offering expenses. Fate Therapeutics intends to use the net proceeds from the offering to fund clinical trials and nonclinical studies of its product candidates, the manufacture of its clinical product candidates, the expansion of its cGMP compliant manufacturing operations, including the construction, commissioning and qualification of its new facility, the conduct of preclinical research and development, and for general corporate purposes.

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Jefferies, BofA Securities, SVB Leerink and Barclays acted as joint book-running managers for the offering. Wells Fargo Securities acted as lead manager for the offering, and Cantor Fitzgerald & Co. and Oppenheimer & Co. Inc. acted as co-managers for the offering.

The securities described above were offered by Fate Therapeutics pursuant to an automatic shelf registration statement on Form S-3 (File No. 333-228513) that was previously filed by Fate Therapeutics with the Securities and Exchange Commission (the "SEC") and automatically became effective upon filing on November 21, 2018. A final prospectus supplement related to the offering was filed with the SEC on January 7, 2021 and is available on the SEC’s website at View Source Copies of the final prospectus supplement and the accompanying prospectus relating to the securities offered may also be obtained by contacting Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, NY 10022, by e-mail at [email protected] or by telephone at (877) 547-6340; BofA Securities, NC1-004-03-43, 200 North College Street, 3rd floor, Charlotte, NC 28255-0001, Attention: Prospectus Department, or by email at [email protected]; SVB Leerink LLC, Attention: Syndicate Department, One Federal Street, 37th Floor, Boston, MA 02110, by telephone at (800) 808-7525 ext. 6132 or by email at [email protected]; or Barclays Capital Inc., c/o Broadridge Financial Solutions, 1155 Long Island Avenue, Edgewood, NY 11717, by telephone at (888) 603-5847 or by email at [email protected].

This press release does not constitute an offer to sell or the solicitation of an offer to buy, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

Heat Biologics to Present at the H.C. Wainwright Virtual BioConnect 2021 Conference

On January 8, 2021 Heat Biologics, Inc. ("Heat") (NASDAQ:HTBX), a clinical-stage biopharmaceutical company focused on developing first-in-class therapies to modulate the immune system, including multiple oncology product candidates and a novel COVID-19 vaccine, reported that it will be presenting at the H.C. Wainwright BioConnect 2021 Conference, being held virtually between January 11-14, 2021 (Press release, Heat Biologics, JAN 8, 2021, View Source [SID1234573700]).

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A webcast of Heat’s presentation will be available on-demand as of 6:00 am ET, Monday, January 11, 2021, and will be accessible for 90 days. The webcast can be accessed here and the investor relations section of Heat Biologics’ website at View Source