Actinium Pharmaceuticals, Inc. Announces Participation in Two Panel Discussions at the 3rd Targeted Radiopharmaceuticals Summit

On December 8, 2021 Actinium Pharmaceuticals, Inc. (NYSE AMERICAN: ATNM) ("Actinium" or the "Company"), a leader in the development of targeted radiotherapies for patients with unmet needs reported its participation in the Targeted Radiopharmaceuticals Summit being held virtually December 7 – 9, 2021 (Press release, Actinium Pharmaceuticals, DEC 8, 2021, View Source [SID1234596585]). The Targeted Radiopharmaceuticals Summit brings together experts and thought leaders in the field with the goal to achieve meaningful clinical efficacy with theragnostic radionuclide therapies in a mono and combinatorial setting & deliver a robust, cGMP compliant manufacturing supply chain. Representatives from Actinium’s R&D and Clinical Development teams have been invited to participate as expert speakers in two panel presentations during the Targeted Radiopharmaceuticals Summit. The panel details are as follows:

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Panel: Review of the Last 12 Months of Development of Alpha Emitting Therapies

Session: Next Generation Alpha Emitter Based Therapeutics

Actinium Expert Speaker: Helen Kotanides, Ph.D., Vice President, Translational Research and Preclinical Development

Date and Time: December 9, 2021, 5:30 pm CET, 11:30 am EST

Panel: High Dose – Low Dose Therapeutic Strategy: Tailoring the Dose of Radiopharmaceuticals for Opportunity and Outcomes

Session: Optimizing Treatment Regimens

Actinium Expert Speaker: Mary Chen, M.D., Ph.D., Vice President, Clinical Development

Date and Time: December 9, 2021, 6:30 pm CET, 12:30 pm EST

Learn more about the Targeted Radiopharmaceuticals Summit at www.targeted-radiopharma.com.

Avistone Pharmaceuticals Secures $200 Million Strategic Investment from Vivo Capital, Bain Capital and Primavera Capital

On December 8, 2021 Avistone Pharmaceuticals ("Avistone" or "the Company"), a clinical-stage biotechnology company focused on precision oncology therapeutics, reported it has received a strategic investment of more than $200 million led by Vivo Capital with participation from Bain Capital and Primavera Capital (collectively the "Investor Group") (Press release, Avistone Pharmaceuticals, DEC 8, 2021, View Source [SID1234596584]). The investment will support the combination of Avistone with Pearl Biotechnology Co. Ltd. to create a fully-integrated targeted oncology platform that will address unmet patient needs globally.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The strategic investment will also support the accelerated development of Avistone’s existing drug candidates, expand its product pipeline through both research and development efforts and business development, enable the combined business to capitalize on opportunities in key markets outside of China, and scale its capabilities to prepare for commercialization.

Based in Beijing, China, Avistone has been committed to the development of precision oncology therapeutics for nearly a decade and has a broad oncology pipeline focused on treatments for lung cancer. The Company’s most advanced asset is a c-Met inhibitor in late-stage clinical development for genetically-defined populations of non-small cell lung cancer (NSCLC) and glioblastoma (GBM). This product candidate has been awarded Breakthrough Therapy designation by China’s National Medical Products Administration (NMPA). In addition, Avistone has an innovative pipeline of tyrosine kinase inhibitors for other molecular drivers of cancer that includes another drug candidate currently in a Phase I dose escalation clinical study. The Company also has several therapeutic compound candidates in pre-clinical and IND-enabling studies.

"Avistone is a science-driven, innovative biotechnology company committed to the discovery and clinical development of first-in-class and best-in-class drugs," said Dr. Hepeng Shi, Chairman, CEO, and Founder of Avistone. "We are thrilled for our company, team, and product pipeline to be recognized by such well-established global life sciences investors as Vivo Capital, Bain Capital, and Primavera Capital. We look forward to leveraging their resources and capabilities to realize our vision to become a global oncology leader that provides more effective treatment options and improves quality of life for patients around the world."

"Vivo Capital is excited to have the opportunity to lead this transformative financing for Avistone. The deal exemplifies Vivo’s investment capabilities in both innovation and private equity transactions in China, as well as extraordinary collaborations both internally, led by Drs. Hongbo Lu and David Liu, and externally, joined by Bain Capital and Primavera Capital." said Shan Fu, Managing Partner and CEO of Greater China for Vivo Capital. "As a global biotech investor with 25 years of history, Vivo is excited to witness the rapid emergence of the Chinese biotech industry. We have known the Avistone team for many years, and we see tremendous value in Avistone’s capabilities in both innovative drug R&D and execution in China. We look forward to partnering with Bain Capital and Primavera Capital to help Avistone bring life-saving therapeutics to patients around the world," added Dr. Hongbo Lu, Managing Partner and CIO of Greater China for Vivo Capital.

"Over the past several years, Bain Capital Life Sciences and Bain Capital Asia Private Equity have systematically studied the life sciences landscape in China to identify the most attractive therapeutic areas and the most promising companies, and this exciting investment represents a culmination of our cross-platform efforts," said Ricky Sun, a Managing Director at Bain Capital Life Sciences. "We are excited to collaborate with Dr. Shi and his team, and to provide the necessary resources to enable the Company to build a best-in-class targeted oncology platform that brings transformative products to patients all over the world."

"The era of precise and personalized cancer treatment has arrived after years of development. However, there are still considerable clinical needs that have not been met," said Jiaqi Zheng, Managing Director of Primavera Capital. "As pioneers in the China pharmaceutical industry, Dr. Shi and his team have accumulated a great deal of expertise in drug discovery and clinical development of targeted therapies. We are delighted to become an investor and strategic partner of Avistone and are committed to supporting the Company’s mission of becoming a leading global biopharmaceutical platform of innovative precision therapeutics."

METiS Therapeutics Launches with $86 Million Series A Financing to Transform Drug Discovery and Delivery with Machine Learning and Artificial Intelligence

On December 7, 2021 METiS Therapeutics reported the company debut with $86 million Series A financing to harness artificial intelligence (AI) and machine learning to redefine drug discovery and delivery and develop optimal therapies for patients with serious diseases (Press release, METiS Therapeutics, DEC 7, 2021, View Source [SID1234648428]). PICC PE and China Life led the financing and were joined by Sequoia Capital China, Lightspeed, 5Y Capital, FreeS Fund and CMBI Zhaoxin Wuji Fund. The financing will be used to advance the company’s pipeline of novel assets with high therapeutic potential and the continued development of its AI-driven drug discovery and delivery platform.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

"METiS is well-positioned to change the drug discovery and delivery landscape with the creation of a proprietary predictive AI platform. We leverage machine learning, AI and quantum simulation to uncover novel drug candidates and to transform drug discovery and development, ultimately bringing the best therapies to patients in need," said Chris Lai, CEO, and Founder, METiS Therapeutics. "We are fortunate that our world-class roster of investors believes in our vision and today’s news represents the first of many significant milestones that we will be accomplishing throughout the next year."

The METiS platform (AiTEM) combines state-of-the-art AI data-driven algorithms, mechanismdriven quantum mechanics and molecular dynamics simulations to calculate Active Pharmaceutical Ingredient (API) properties, elucidate API-target and API-excipient interactions, and predict chemical, physical and pharmacokinetic properties of small molecule and nucleic acid therapeutics in specific microenvironments. This enables efficient lead optimization, candidate selection and formulation design. Founded by a team of MIT researchers, serial entrepreneurs and biotech industry veterans, METiS develops and in-licenses novel assets with high therapeutic potential that could benefit from its data-driven platform.

Starpharma signs DEP Research Agreement with US Biopharma Co

On 7 December 2021 Starpharma reported that it has signed an exploratory DEP Research Agreement with Genentech, a member of the Roche Group, with an initial focus on evaluating DEP (dendrimer based) drug conjugates (Press release, Starpharma, DEC 7, 2021, View Source [SID1234634709]).

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

Starpharma also has a number of existing DEP partnerships with leading international pharmaceutical companies, including AstraZeneca, Merck & Co., Inc., Chase Sun, as well as several undisclosed partnerships.

Starpharma’s DEP technology has already yielded four clinical stage products.

About DEP
Starpharma’s proprietary dendrimer-based DEP platform has broad commercial applicability in drug delivery by enhancing the therapeutic utility of drugs through improved solubility, efficacy and pharmacokinetic control, reductions in certain toxicities (e.g., bone marrow toxicity) and creating a unique intellectual property position. The novel DEP platform has shown reproducible advantages across a wide range of drug classes and can be utilised with both small molecule drugs, peptides and proteins, and in the development of unique DEP based ADCs, radiotherapies and radiodiagnostics.

Potential benefits of DEP dendrimer drug delivery include:
• Improving efficacy
• Improving therapeutic index
• Reducing toxic side effects of drugs
• Enhanced and controllable pharmacokinetics
• Tumour targeting
• Increased aqueous solubility, avoiding the need for toxic excipients (e.g., polysorbate-80) thus reducing the need for steroid pre-treatment
• Delivering a variety of payloads (small molecules, proteins, radio-isotopes)
• Creation of new intellectual property

Starpharma has three phase 2 clinical stage DEP assets, multiple preclinical DEP programs, and has applied its DEP technology in partnership with pharmaceutical companies for many different applications (passive and targeted ADC and radiotheranostics) and diseases (oncology and nononcology applications).

Entry into a Material Definitive Agreement

On December 7, 2021, Propanc Biopharma, Inc. (the "Company") reported that it entered into a securities purchase agreement (the "Purchase Agreement") with ONE44 Capital LLC, ("ONE44"), pursuant to which ONE44 purchased a convertible promissory note (the "Note") from the Company in the aggregate principal amount of $170,000, such principal and the interest thereon convertible into shares of the Company’s common stock at the option of ONE44 (Filing, 8-K, Propanc, DEC 7, 2021, View Source [SID1234597015]). The transaction contemplated by the Purchase Agreement is expected to close on or about December 13, 2021. The Company intends to use the net proceeds ($153,000) from the Note for general working capital purposes. The Note contains an original issue discount amount of $17,000.

Schedule your 30 min Free 1stOncology Demo!
Discover why more than 1,500 members use 1stOncology™ to excel in:

Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

                  Schedule Your 30 min Free Demo!

The maturity date of the Note is December 7, 2022 (the "Maturity Date"). The Note shall bear interest at a rate of 10% per annum, which interest may be paid by the Company to ONE44 in shares of common stock, but shall not be payable until the Note becomes payable, whether at the Maturity Date or upon acceleration or by prepayment, as described below. ONE44 has the option to convert all or any amount of the principal face amount of the Note, starting on June 5, 2022, and ending on the later of the Maturity Date and the date of payment of the Default Amount (as defined below) is paid if an event of default occurs, for shares of the Company’s common stock at the then-applicable conversion price. The conversion price for the Note shall be equal to the Conversion Price (as defined herein) (subject to equitable adjustments for stock splits, stock dividends or rights offerings by the Company relating to the Company’s securities or the securities of any subsidiary of the Company, combinations, recapitalization, reclassifications, extraordinary distributions and similar events). The "Conversion Price" shall mean 65% multiplied by the lowest closing bid price of the Company’s common stock as reported on the OTC Markets. Notwithstanding the foregoing, ONE44 shall be restricted from effecting a conversion if such conversion, along with other shares of the Company’s common stock beneficially owned by ONE44 and its affiliates, exceeds 4.99% of the outstanding shares of the Company’s common stock.

The Note may be prepaid until 180 days from the issuance date. If the Note is prepaid within 60 days of the issuance date, then the prepayment premium shall be 120% of the face amount plus any accrued interest, if prepaid after 60 days from the issuance date, but less than 120 days from the issuance date, then the prepayment premium shall be 130% of the face amount plus any accrued interest, if prepaid after 120 days from the issuance date, up to 180 from the issuance date, then the prepayment premium shall be 135% of the face amount plus any accrued interest. So long as the Note is outstanding, the Company covenants not to, without prior written consent from ONE44, sell, lease or otherwise dispose of all or substantially all of its assets outside the ordinary course of business which would render the Company a "shell company" as such term is defined in Rule 144.

Other than as described above, the Note contains certain events of default, including failure to timely issue shares upon receipt of a notice of conversion, as well as certain customary events of default, including, among others, breach of covenants, representations or warranties, insolvency, bankruptcy, liquidation and failure by the Company to pay the principal and interest due under the Note.

Upon the occurrence and during the continuation of certain events of default, the Note will accrue an interest rate of 24%.

The Note was issued, and any shares to be issued pursuant to any conversion of the Note shall be issued, in a private placement in reliance upon an exemption from registration provided by Section 4(a)(2) of the Securities Act and/or Regulation D promulgated thereunder.

The foregoing description of the Note and the Purchase Agreement does not purport to be complete and is qualified in their entirety by reference to the full text of the Purchase Agreement and the Note, which are filed as Exhibits 4.1 and 10.1, respectively, to this Current Report on Form 8-K and are incorporated herein by reference.