BIO-Europe, 25-28 October 2021

On October 6, 2021 Sijme Zeilemaker, CEO of Immunetune, reported that it will be attending BIO-Europe, taking place October 25-28, 2021, in digital format (Press release, ImmuneTune, OCT 6, 2021, View Source [SID1234590854]). Feel free to reach out to us to set up a meeting and explore collaboration and investment opportunities.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Newly Formed Lanier Biotherapeutics Enters into License Agreement with Alloy Therapeutics

On October 05, 2021 Lanier Biotherapeutics Inc., a developer of first-in-class antibodies targeting retina, dermatology, and Type 2 Inflammatory specialty diseases, reported that it has entered into a license agreement (the "Agreement") with Alloy Therapeutics ("Alloy"), a privately held drug discovery company (Press release, Abeome, OCT 5, 2021, View Source [SID1234592023]).

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Alloy will acquire the AbeoMouse and Direct Selection of Hybridomas (DiSH) antibody discovery technologies, which were originally developed by Abeome Corporation, Inc. ("Abeome"), one of Lanier’s two predecessor companies. Upon closing of the Agreement, Alloy will license to Lanier certain rights to AbeoMouse and Alloy’s ATX-Gx platform of proprietary transgenic mouse strains.

"We are pleased to enter into this mutually beneficial Agreement, which provides both companies with access to enabling antibody discovery technologies while augmenting our development pipeline and further strengthening our balance sheet," said Kirby Alton, Lanier’s Chairman.

Lanier was recently formed by combining the businesses of Abeome and Biophtha Inc., with bridge funding from investors, including founders Kirby Alton, PhD, former Senior Vice President of Development at Amgen; and Daniel White, MBA, former CEO of Clearside Biomedical. Messrs. Alton and White are joined by Lanier’s other two founders, Martin Simonetti, MS, MBA and Chris McLeod, MS, to form Lanier’s experienced leadership team:

President, CEO & Director, Daniel White, is an accomplished entrepreneur and visionary in the biotech and pharmaceutical space. As the founder and CEO of Clearside Biomedical, he led the company from early private financing through its initial public offering and brings a wealth of biomedical development and successful fundraising experience.
Chairman, Kirby Alton, reprises his role of Chairman of Abeome, and brings deep product development expertise gained as one of Amgen’s original scientists.
Director, Martin Simonetti, has significant Amgen and Genentech experience; an immense track record of leadership and growth across several biotechnology enterprises; and has led successful financings in both private and capital markets.
Director, Chris McLeod, is an experienced biotechnology executive with vast expertise in growth companies and strategic collaborations. He is a former Executive Vice President of CuraGen and President of 454 Life Sciences; and is the current managing partner of Elm Street Ventures.
Lanier is developing a portfolio of 11 first-in-class therapeutic antibodies for specialty disease across four major verticals: Multi-functional Retina, Type 2 Inflammation, Dermatology, and ImmunoOncology.

"With a robust portfolio of 11 first-in-class, proprietary therapeutic antibodies, we are eager to progress toward the clinic with our two lead candidates: one targeting retinal disease using our multifunction anti VEGF inhibitor and the second using the most advanced and proprietary anti IL25 to treat Type 2 Inflammatory diseases," said Daniel White, President and CEO of Lanier. "Lanier has initiated a fund raise to launch these two programs that hold promise for improving treatment to provide a better life for patients."

Multi-functional Retina

Lanier’s LNR 653.1 is a proprietary bifunctional antibody being developed for the treatment of retinal neovascularization diseases (wet age-related macular degeneration, diabetic macular edema and retinal vein occlusion. LNR 653.1 is designed to combine the anti-vascular endothelial growth factor (VEGF) effect of aflibercept (marketed as Eylea by Regeneron) with the anti-inflammatory and anti-apoptotic effects similar to that of secukinumab (marketed as Cosentyx by Novartis). Preclinical data suggest that LNR 653.1 is safe, with efficacy similar or superior to aflibercept. Lanier is currently conducting pre-formulation experiments and non-clinical functional testing, with plans to initiate investigational new drug ("IND")-enabling studies of LNR 653.1 in 2022.

Type 2 Inflammation

LNR 125.38 is a monoclonal antibody that inhibits the upstream cytokine IL-25. By reducing, or even eliminating the effects of downstream allergic and antiviral cytokines, LNR 125.38 targets Type 2 Inflammation, which is implicated in different atopic, allergic and inflammatory diseases. Lanier is prioritizing the development of LNR 125.38 across a broad range of potential treatments of moderate to severe asthma that is classified as either high or low eosinophil challenge by allergy or rhinovirus; chronic sinusitis with nasal polyps; and eosinophil esophagitis and gastritis. Preclinical data have demonstrated that LNR 125.38 significantly reduces Type 2 (downstream) cytokines and inflammatory cells in allergic mouse and rhinovirus-induced asthma exacerbations. Lanier is currently conducting pre-formulation experiments and non-clinical functional testing, with plans to initiate IND-enabling studies of LNR 125.38 in the second half of 2022.

Dermatology

Lanier is developing LNR 653.1 for the treatment of psoriasis, where functional testing has demonstrated potency and efficacy comparable to secukinumab and ixekizumab (marketed as Taltz by Eli Lilly). The Company is also developing LNR 125.38 for the treatment of chronic urticaria and atopic dermatitis.

ImmunoOncology

MT-6402 is an engineered toxin body manufactured by Molecular Templates, Inc., which contains a PDL-1 inhibitor previously licensed by it from Lanier’s extensive library of proprietary checkpoint inhibitors. In July, Molecular Templates dosed the first subject in a Phase 1 study evaluating MT-6402 in patients with PD-L1-positive solid tumors and expects to provide an update on the study by the end of this year.

Twist Bioscience Expands Expert Custom Alliance Panel Offering

On October 5, 2021 Twist Bioscience Corporation (NASDAQ: TWST), a company enabling customers to succeed through its offering of high-quality synthetic DNA using its silicon platform, reported an expansion of its expert-led Alliance Panel product offering (Press release, Twist Bioscience, OCT 5, 2021, View Source [SID1234590884]). Designed through collaboration with world-leading experts, Twist Alliance Panels combine validated content with Twist next-generation sequencing (NGS) workflow, target enrichment and DNA probes. In an extension of Twist’s OEM strategy, Twist will market products designed by key opinion leaders in a wide range of clinical applications and powered by Twist tools through the Alliance Panel program. In return, expert collaborators receive a royalty on the sale of products and will carry partner branding.

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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"Data generated and validated by experts around the world bring incredible value to the research community," said Emily M. Leproust, Ph.D., CEO and co-founder of Twist Bioscience. "By working together, we are leveraging this extensive knowledge, providing the global community with better research tools, all powered by Twist products, and also ensuring the experts involved receive recognition and royalties for their hard work."

As the first Alliance Panel offering, Twist collaborated with the Regeneron Genetics Center LLC (RGC), a wholly-owned subsidiary of Regeneron, to develop the Twist Diversity SNP Panel, a custom NGS population genetics genotyping assay available to researchers globally for population genomics studies.

Today, Twist and AnchorDx launched the Twist Alliance Pan-cancer Methylation Panel based on The Cancer Genome Atlas (TCGA) database, including 31 cancer types and 47 TCGA database disease entities. The pan-cancer profile saves customers sequencing costs and reduces the complexity of analysis. Validation studies were conducted using tumor biopsy samples from breast cancer, colorectal cancer and non-small cell lung cancer. DNA methylation regions included in the panel have been found to clearly differentiate cancer tissues from the non-malignant tissue in these three cancer types, among the most common cancers.

About Twist Alliance Panels

In partnership with leading research institutions from around the world, Twist has curated a collection of high-quality target enrichment panels for applications ranging from carrier screening to cancer diagnostics and whole exome sequencing. The Twist Alliance Panels combine the strengths of precise, highly uniform oligonucleotide synthesis with the specialty expertise of leading scientific research partners.

Well designed, custom target enrichment panels enable increased sequencing depth on target genes while reducing overall sequencing. This allows for more sensitive detection of target sequences and higher confidence variant detection.

CRISPR Therapeutics to Host Virtual Event Highlighting CTX110™ Clinical Data

On October 5, 2021 CRISPR Therapeutics (Nasdaq: CRSP), a biopharmaceutical company focused on creating transformative gene-based medicines for serious diseases, reported that management will host a virtual event on October 12, 2021 at 4:30 p.m. ET to highlight clinical data from its ongoing Phase 1 CARBON trial assessing the safety and efficacy of CTX110, its wholly-owned allogeneic chimeric antigen receptor T cell (CAR-T) investigational therapy targeting CD19, for the treatment of relapsed or refractory B-cell malignancies (Press release, CRISPR Therapeutics, OCT 5, 2021, View Source [SID1234590883]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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Conference Call and Webcast
To access the conference call, please dial +1 (866) 952-8559 (domestic) or +1 (785) 424-1743 (international) and reference the conference ID "CRISPR."

A live webcast of the event will be available on the "Events & Presentations" page in the Investors section of the Company’s website at View Source A webcast replay will be available on the CRISPR Therapeutics website after the event and will be archived for 14 days.

About CTX110
CTX110, a wholly owned program of CRISPR Therapeutics, is a healthy donor-derived gene-edited allogeneic CAR-T investigational therapy targeting Cluster of Differentiation 19, or CD19. CTX110 is being investigated in the ongoing CARBON trial.

About CARBON
The ongoing Phase 1 single-arm, multi-center, open label clinical trial, CARBON, is designed to assess the safety and efficacy of several dose levels of CTX110 for the treatment of relapsed or refractory B-cell malignancies.

Lipocine to Present at The H.C. Wainwright 5th Annual NASH Investor Conference

On October 5, 2021 Lipocine Inc. (NASDAQ: LPCN), a clinical-stage biopharmaceutical company focused on metabolic and endocrine disorders, reported that the Company will present at the H.C. Wainwright 5th Annual NASH Investor Conference being held virtually on October 12, 2021 (Press release, Lipocine, OCT 5, 2021, View Source [SID1234590877]).

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Early/Late Stage Pipeline Development - Target Scouting - Clinical Biomarkers - Indication Selection & Expansion - BD&L Contacts - Conference Reports - Combinatorial Drug Settings - Companion Diagnostics - Drug Repositioning - First-in-class Analysis - Competitive Analysis - Deals & Licensing

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H.C. Wainwright 5th Annual NASH Investor Conference, October 12, 2021

Presentation time: 3:30 pm ET

Webcast link: View Source

A webcast of Lipocine’s presentation will be available on Lipocine’s website under "Events & Presentations" in the Investors section or using the webcast link above. The webcast will be available on the Lipocine’s website for 90 days.