On October 6, 2021 Citius Pharmaceuticals, Inc. ("Citius" or the "Company") (Nasdaq: CTXR), a late-stage biopharmaceutical company dedicated to the development and commercialization of first-in-class critical care products with a focus on oncology, anti-infective products in adjunct cancer care, unique prescription products, and stem cell therapies, reported that it will present at two investor conferences during the month of October 2021 (Press release, Citius Pharmaceuticals, OCT 6, 2021, View Source [SID1234590872]).

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EVENT: Benzinga Rising Stars: Catalytic Small Cap Growth Conference
DATE: Thursday, October 7, 2021
Citius Executive Chairman Leonard Mazur will present at 9:05 a.m. ET. His presentation will be available for viewing on Benzinga’s live stream channel.

EVENT: Dawson James Securities 6th Annual Small Cap Growth Conference
DATE: Thursday, October 21, 2021
Citius Executive Chairman Leonard Mazur will present at 8:55 a.m. ET in Track 1 and will be available for 1-on-1 meetings with registered conference attendees. The conference will be held October 20-21 at the Wyndham Grand Jupiter at Harbourside Place in Jupiter, Florida. A webcast of the presentation will be available on the Events page of the Citius Investors website.

At the conferences, Mr. Mazur will discuss the Company’s growing pipeline of therapies targeting unmet medical needs consisting of two late-stage assets completing Phase 3 trials, three potential first-and-only prescription treatments in their indications, and a next-generation stem cell therapy program.

On October 6, 2021 Theseus Pharmaceuticals, Inc. ("Theseus"), a biopharmaceutical company focused on improving the lives of cancer patients through the discovery, development and commercialization of transformative targeted therapies, reported the pricing of its initial public offering of 10,000,200 shares of its common stock at a price to the public of $16.00 per share (Press release, Theseus Pharmaceuticals, OCT 6, 2021, View Source [SID1234590871]). All of the shares are being offered by Theseus. The gross proceeds to Theseus from the offering, before deducting underwriting discounts, commissions and other offering expenses payable by Theseus, are expected to be $160 million. In addition, Theseus has granted the underwriters a 30-day option to purchase up to an additional 1,500,030 shares of common stock from Theseus at the initial public offering price less underwriting discounts and commissions.

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Theseus’s common stock is expected to begin trading on The Nasdaq Global Select Market under the ticker symbol "THRX" on October 7, 2021. The offering is expected to close on or about October 12, 2021, subject to the satisfaction of customary closing conditions.

Jefferies, SVB Leerink and Cantor are acting as joint book-running managers for the offering. Wedbush PacGrow is acting as lead manager.

A registration statement relating to the securities being sold in the offering was declared effective by the Securities and Exchange Commission ("SEC") on October 6, 2021. The offering is being made only by means of a written prospectus. Copies of these documents can be accessed by visiting the SEC website at View Source Alternatively, copies of the final prospectus relating to the offering can be obtained, when available, from Jefferies LLC, Attention: Equity Syndicate Prospectus Department, 520 Madison Avenue, 2nd Floor, New York, NY 10022, by telephone at (877) 821-7388, or by email at [email protected]; SVB Leerink LLC, Attention: Syndicate Department, 53 State Street, 40th Floor, Boston, MA 02109, by telephone at (800) 808-7525, ext. 6105, or by email at [email protected]; Cantor Fitzgerald & Co., Attention Capital Markets, 499 Park Avenue, 4th Floor, New York, NY 10022, or by e-mail at [email protected].

This press release shall not constitute an offer to sell or the solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or jurisdiction in which such offer, solicitation or sale would be unlawful prior to registration or qualification under the securities laws of any such state or jurisdiction.

On October 6, 2021 Veracyte, Inc. (Nasdaq: VCYT) reported that four abstracts highlighting the clinical impact of the company’s genomic diagnostic tests for lung cancer and interstitial lung disease (ILD) will be presented at the American College of Chest Physicians (CHEST) Annual Meeting 2021, being held virtually October 17-20, 2021 (Press release, Veracyte, OCT 6, 2021, View Source [SID1234590870]).

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The abstracts include new data from an expanded clinical validation study which demonstrate the ability of Veracyte’s Percepta Nasal Swab test to determine cancer risk in patients with lung nodules found on CT scans – across lung nodule sizes, lung cancer stages and patients’ prior-cancer status. Veracyte developed the novel noninvasive test to help physicians more accurately, quickly and confidently determine which patients can be safely directed to routine monitoring and which should proceed to further diagnostic work-up and treatment as needed.

"The Percepta Nasal Swab is a key component of Veracyte’s lung cancer portfolio and expands our ability to answer clinical questions across the patient journey in lung cancer," said Marc Stapley, Veracyte’s chief executive officer. "Collectively, the new data that will be presented at this year’s CHEST meeting demonstrate the power of our cutting-edge genomic science and technology to help physicians and patients make better, faster and more confident care decisions in serious lung diseases."

Additional abstracts to be presented at the CHEST meeting provide further evidence that Veracyte’s Percepta and Envisia classifiers deliver valuable genomic information that helps guide patient care in lung cancer and ILDs (including idiopathic pulmonary fibrosis), respectively.

Following are details of the four abstracts:

Date/Time:

Sunday, October 17, 9:15 a.m.-10:20 a.m. CT

Title:

A Nasal Clinical-Genomic Classifier for Assessing Risk of Malignancy in Lung Nodules Demonstrates Accurate Performance Independent of Nodule Size or Cancer Stage

Abstract #:

39959 (oral presentation)

Presenter:

Carla R. Lamb, M.D., Lahey Hospital & Medical Center

Date/Time:

Sunday, October 17, 9:15 a.m.-10:20 a.m. CT

Title:

Impact of Percepta Bronchial Genomic Classifier on Lung Nodule Management at an Academic Medical Center

Abstract #:

39994 (oral presentation)

Presenter:

Harpreet Singh, M.D., Medical College of Wisconsin

Date/Time:

Monday, October 18, 12:15 p.m.-1:20 p.m. CT

Title:

The Impact of the Envisia Genomic Classifier in the Diagnosis and Management of Patients with Interstitial Lung Disease

Abstract #:

40063 (oral presentation)

Presenter:

Joseph Lasky, M.D., Tulane University Medical School

Date/Time:

On-Demand October 17-21

Title:

Role of Next Generation Sequencing with Percepta Brushing in Reclassifying Lung Nodule Risk After Non-Diagnostic Bronchoscopy

Abstract #:

36774 (poster)

Presenter:

Abhijit Raval, M.D., AnMed Health Medical Center

On October 6, 2021 Targovax ASA (OSE: TRVX), a clinical stage immuno-oncology company developing immune activators to target hard-to-treat solid tumors, reported that two abstracts has been accepted for poster presentation at the Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) Annual Meeting.
The abstracts will be released on the SITC (Free SITC Whitepaper) website 9 November 14:00 CEST (www.sitcancer.org/2021/home). The posters are scheduled for presentation during the SITC (Free SITC Whitepaper) congress 12-14 November 2021.

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Poster title: A randomised open-label phase I/II study adding ONCOS-102 to pemetrexed/cisplatin in patients with unresectable malignant pleural mesothelioma – 24-month survival data
E-poster number: 462
Lead author: Dr Luis Paz-Ares, Medical Oncology, Hospital Universitario 12 Octubre, Madrid, Spain

Poster title: Consistent pattern of immune activation induced by oncolytic adenovirus ONCOS-102 across diverse types of solid tumors
E-poster number: 368
Lead author: Lukasz Kuryk, PhD, Director Clinical Science, Targovax
***

About SITC (Free SITC Whitepaper)

The Society for Immunotherapy of Cancer (SITC) (Free SITC Whitepaper) Annual Meeting & Pre-Conference Programs brings together stakeholders across the cancer immunotherapy field to advance the science, discover breakthroughs and educate the world on cancer immunotherapy.

As the largest conference solely focused on cancer immunotherapy, the Annual Meeting & Pre-Conference Programs provides international leaders from academia, regulatory and government agencies, as well as industry representatives with a multidisciplinary educational and interactive environment focused on improving outcomes for all cancer patients.

On October 6, 2021 Viracta Therapeutics, Inc. (Nasdaq: VIRX), a precision oncology company targeting virus-associated malignancies, reported the initiation of a multinational Phase 1b/2 trial in patients with EBV+ recurrent or metastatic nasopharyngeal carcinoma (RM-NPC) and other EBV+ solid tumors (Press release, Sunesis, OCT 6, 2021, View Source [SID1234590868]). The trial is designed to evaluate the safety and preliminary efficacy of nanatinostat in combination with valganciclovir (Nana-val) alone and in combination with the PD-1 checkpoint inhibitor pembrolizumab.

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"The initiation of this Phase 1b/2 trial is a key step towards expanding the development of our unique therapeutic approach beyond EBV+ lymphoproliferative disorders. Nasopharyngeal carcinoma is highly associated with EBV, and treatment options for patients with advanced or recurrent EBV+ solid tumors are limited," said Lisa Rojkjaer, M.D., Chief Medical Officer of Viracta. "We are encouraged by the preliminary data that Nana-val has demonstrated in relapsed/refractory EBV+ lymphoma and look forward to evaluating the activity of our novel oral combination regimen in patients with EBV+ solid tumors."

The Phase 1b/2 trial is an open-label, multicenter trial evaluating Nana-val alone and in combination with pembrolizumab. The Phase 1b dose escalation portion is designed to evaluate safety and to determine the recommended Phase 2 dose (RP2D) of Nana-val in patients with EBV+ RM-NPC. In Phase 2, up to sixty patients with EBV+ RM-NPC will be randomized to receive Nana-val at the RP2D with or without pembrolizumab, to evaluate safety, overall response rate, and potential pharmacodynamic markers. Additionally, patients with other EBV+ solid tumors will be enrolled to receive Nana-val at the RP2D in a Phase 1b dose expansion cohort.

About Nanatinostat

Nanatinostat (VRx-3996) is an orally available histone deacetylase (HDAC) inhibitor being developed by Viracta. Nanatinostat is selective for specific isoforms of Class I HDACs, which is key to inducing viral genes that are epigenetically silenced in EBV-associated malignancies. Nana-val (nanatinostat and valganciclovir) is being investigated in multiple subtypes of relapsed/refractory EBV+ lymphoma and in advanced EBV+ solid tumors in three ongoing trials, one of which is a registration-enabling global, multicenter, open-label Phase 2 basket trial in relapsed/refractory EBV+ lymphoma (NAVAL-1).