On September 28, 2021 Gamida Cell Ltd. (Nasdaq: GMDA), an advanced cell therapy company committed to cures for blood cancers and serious blood diseases, reported that it will host a virtual event detailing the company’s proprietary NAM-enabled natural killer (NK) cell therapy pipeline on Tuesday, October 26, 2021 at 8:00 a.m. ET (Press release, Gamida Cell, SEP 28, 2021, View Source [SID1234590411]).

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During the event, the company will highlight updates on the clinical development of GDA-201, its lead cryopreserved, off-the-shelf cell therapy candidate for the treatment of patients with follicular and diffuse large b-cell lymphomas, and Gamida Cell’s new development programs leveraging next-generation, NAM-enabled, genetically modified NK cells in development for solid tumors and hematological cancers. Specifically, Gamida Cell will provide an update on the following genetically modified NK cell therapies:

GDA-301, a CISH knockout and membrane-bound IL-15 NK cell construct that has demonstrated increased potency against leukemia and multiple myeloma cell lines
GDA-501, a CAR-HER2 NK cell construct that has shown increased cytotoxicity against an ovarian tumor cell line
GDA-601, a CD38 knockout + CD38 CAR NK cell construct that has yielded increased cytotoxicity against a multiple myeloma cell line
The event will feature management presentations and participation by the following speakers:

Jeff Miller, M.D., Professor of Medicine, Division of Hematology, Oncology and Transplantation at University of Minnesota
Veronika Bachanova, M.D., Ph.D., Hematologist/Oncologist at University of Minnesota Health
Patient treated with GDA-201
The live event will be available at the following link. A replay of the webcast will be available on the "Investors & Media" section of Gamida Cell’s website at www.gamida-cell.com, and will be available for at least 14 days following the event.

About GDA-201

Gamida Cell applied the capabilities of its nicotinamide (NAM)-based cell expansion technology to develop GDA-201, an innate NK cell immunotherapy for the treatment of hematologic and solid tumors in combination with standard of care antibody therapies. GDA-201, the lead candidate in the NAM-enabled NK cell pipeline, has demonstrated promising initial clinical trial results, as reported at the 2020 American Society of Hematology (ASH) (Free ASH Whitepaper) Annual Meeting & Exposition1. GDA-201 addresses key limitations of NK cells by increasing the cytotoxicity and in vivo retention and proliferation in the bone marrow and lymphoid organs. Furthermore, GDA-201 improves antibody-dependent cellular cytotoxicity (ADCC) and tumor targeting of NK cells. For more information on the clinical study of GDA-201, please visit View Source and www.clinicaltrials.gov.

GDA-201 is an investigational therapy, and its safety and efficacy have not been established by the FDA or any other health authority.

On September 28, 2021 Castle Biosciences, Inc. (Nasdaq: CSTL), a dermatologic diagnostics company providing personalized genomic information to inform treatment decisions, reported that Derek Maetzold, president and chief executive officer, will deliver the keynote presentation during Arizona Bioscience Week, taking place from Oct. 3-9, 2021 (Press release, Castle Biosciences, SEP 28, 2021, View Source [SID1234590410]). Arizona Bioscience Week is presented by the Arizona Bioindustry Association (AZBio) and the Arizona Commerce Authority.

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As demonstrated through Arizona Bioscience Week, Arizona’s bioscience industry is committed to discovering, developing and delivering innovative medicines, medical devices and healthcare technologies that make life better for people in Arizona and around the world.

"As we continue to grow the bioscience industry in Arizona, we are grateful for companies like Castle Biosciences, who are committed to patient care and supporting the future business leaders of tomorrow," said Joan Koerber-Walker, president and chief executive officer of AZBio. "Derek’s and Castle’s success are a testament to the power and importance of having a strong vision from the beginning – keeping patient care at the forefront of business – and we are excited to hear Derek share his story with other up-and-comers in the life science industry."

"I am honored to have the opportunity to keynote Arizona Bioscience Week," said Derek Maetzold, president and CEO of Castle Biosciences. "This event benefits AZAdvances, part of the Opportunity Through Entrepreneurship Foundation that is providing not only funding but also mentorship for the life science innovators of tomorrow. Castle is proud to support this organization, future innovation and the Arizona bioscience community."

Maetzold’s keynote presentation will take place during the AZAdvances Innovation Showcase on Oct. 6. To register or learn more about the events taking place during Arizona Bioscience Week, visit View Source

About Arizona Bioindustry Association

The Arizona Bioindustry Association (AZBio) is a not-for-profit, 501(c)(6) trade association supporting the growth of Arizona’s life science sector. AZBio member organizations in the fields of business, research and education, health care delivery, economic development, government and other professions involved in the biosciences are the key drivers of the growth of Arizona’s life science sector. As the unified voice of our industry in Arizona, AZBio strives to make Arizona a place where bioscience organizations can grow and succeed.

AZBio works nationally and globally with the Advanced Medical Technology Association (AdvaMed), the Biotechnology Innovation Organization (BIO), the Medical Device Manufacturers Association (MDMA), the Pharmaceutical Research and Manufacturers of America (PhRMA) and leading patient advocacy organizations.

Through these relationships, AZBio has access to information, contacts, resources, cost saving programs and the global bioscience and medtech community.

On September 28, 2021 Kintara Therapeutics, Inc. (Nasdaq: KTRA) ("Kintara" or the "Company"), a biopharmaceutical company developing novel cancer therapies for patients who are failing, or are resistant to, current treatment regimens reported the closing of its previously announced registered direct offering, priced at-the-market under Nasdaq rules, with several healthcare-focused institutional investors of 12,000,000 shares of its common stock (or common stock equivalents) and warrants to purchase up to an aggregate of 12,000,000 shares of common stock, at a combined offering price of $1.25 per share and associated warrant (Press release, Kintara Therapeutics, SEP 28, 2021, View Source [SID1234590409]). The warrants have an exercise price of $1.25 per share and are exercisable for three and one half years from the date of issuance. The gross proceeds to the Company totaled approximately $15 million, before deducting placement agent fees and offering expenses.

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H.C. Wainwright & Co. acted as the exclusive placement agent for the offering.

The Company currently intends to use the net proceeds from the offering for funding its clinical studies, working capital and other general corporate purposes, including, but not limited to, funding acquisitions or investments in businesses, products or technologies that are complementary to the Company’s businesses, products and technologies.

The securities described above were offered by the Company pursuant to a "shelf" registration statement on Form S-3 (File No. 333-254662) filed with the Securities and Exchange Commission (SEC) on March 24, 2021 and declared effective on April 1, 2021. The offering of the securities described herein was made only by means of a prospectus, including a prospectus supplement, forming a part of the effective registration statement. A final prospectus supplement and accompanying prospectus relating to the securities being offered was filed with the SEC. Electronic copies of the final prospectus supplement and accompanying prospectus may be obtained on the SEC’s website at View Source or by contacting H.C. Wainwright & Co., LLC, 430 Park Avenue, 3rd Floor, New York, NY 10022, by telephone at (646) 975-6996, or email at [email protected].

This press release shall not constitute an offer to sell or a solicitation of an offer to buy these securities, nor shall there be any sale of these securities in any state or other jurisdiction in which such offer, solicitation or sale would be unlawful prior to the registration or qualification under the securities laws of any such state or other jurisdiction.

On September 28, 2021 Lantern Pharma (NASDAQ: LTRN), a clinical stage biopharmaceutical company using its proprietary RADR artificial intelligence ("A.I.") platform to transform the cost, pace, and timeline of oncology drug discovery and development and Deep Lens, a digital healthcare company focused on enabling faster recruitment of the best-suited cancer patients for clinical trials at the time of diagnosis, reported that they have entered into a strategic collaboration that will leverage Deep Lens’ artificial intelligence clinical trial matching solution, VIPERÔ, creating an end-to-end A.I. enabled drug development pathway that is expected to accelerate trial enrollment for Lantern’s planned Phase 2 clinical trial for never-smokers with non-small cell lung cancer (NSCLC), utilizing LP-300 in combination with chemotherapy (Press release, Lantern Pharma, SEP 28, 2021, View Source [SID1234590408]).

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Lantern is developing oncology therapies by leveraging its proprietary RADR A.I. platform and machine learning to discover biomarker signatures that identify patients most likely to respond to its pipeline of therapeutics. Deep Lens’ proprietary A.I.-based platform, VIPER, identifies, triages and matches cancer patients to clinical trials in real time for which they may be eligible. Together, the companies are addressing two of the most complex and time-consuming parts of the drug development process: matching a novel molecule with a relevant indication and identifying the right patients to participate in clinical trials.

Panna Sharma, President & CEO of Lantern Pharma, stated, "The current drug development model is extremely expensive, with an estimated $2.6 billion in drug development costs for each Food and Drug Administration (FDA)-approved drug. Moreover, based on the estimated 5.3% success rate for oncology drugs, most therapies, will fail to reach commercialization, despite showing efficacy in certain subgroups. Not only do the majority of therapies in development fail to meet safety or efficacy endpoints, but an equally large number, 75% of clinical trials, fail to meet recruitment deadlines, due in large part to enrollment challenges. It is quite apparent that cancer treatment requires a lower cost of care and an increase in the choice and efficacy of precision therapies, which we believe we can deliver through a combination of A.I., machine learning, and large-scale biomarker analytics, with a goal of ultimately crushing the cost of cancer therapy development. For this reason, we are very excited to partner with Deep Lens and create an end-to-end A.I. enabled pathway from drug rescue to patient recruitment."

Mr. Sharma continued, "Our existing A.I. platform allows us to predict drug outcomes and response in very specific patient subsets, while Deep Lens’ VIPER serves as a tool to find and accelerate the enrollment of appropriate patients for clinical trials. We believe this accelerated and efficient process will help more cancer patients to have access to the right medicine at the right time. We hope to leverage this solution across additional trials and combine it with other advanced A.I. technologies that align with our mission of accelerating the timeline and reducing the costs of oncology drug discovery and development."

Lantern Pharma’s approach is to in-license and develop oncology therapies using genomic data, machine learning, and computational biology modeling to identify the patient groups most likely to respond to a therapy, and to clarify the potential underlying mechanisms of action. Lantern’s LP-300 is a small molecule entity that has been studied in multiple randomized, controlled multi-center NSCLC trials. In retrospective analyses of a multi-country Phase 3 trial, LP-300 with chemotherapy demonstrated substantial improvement in overall survival in the never-smoker subgroup. LP-300 is currently in preparation to enter a phase 2 clinical trial for use of LP-300 as a combination therapy for never-smoking NSCLC patients with histologically defined adenocarcinoma. Deep Lens will utilize the patient enrollment criteria identified by Lantern to find this subgroup of patients and match them to the LP-300 clinical trial across Deep Lens’ network of community oncology sites.

"Precision medicine has changed the way we think about treating and identifying certain types of cancer, but it has also significantly increased the complexity of clinical trials. Trials often have very narrow eligibility criteria, making enrollment objectives difficult to meet, and unfortunately, many companies will fail to move along the development path successfully," said Dave Billiter, Chief Executive Officer and Co-Founder of Deep Lens. "Deep Lens leverages their A.I. platform, VIPER, and supporting services to automate the patient identification and screening process, so that trials enroll faster and more efficiently. We believe that leveraging A.I. across multiple phases of drug development will decrease overall time-to-market timelines as well as associated costs. We look forward to partnering with Lantern to help them achieve their trial enrollment goals and to provide access to LP-300 to patients in need as quickly as possible."

Lantern is focused on developing LP-300 as a potential first-in-class combination therapy for never smoking NSCLC patients with histologically defined adenocarcinoma. NSCLC among never smokers has a distinct molecular profile and according to the American Cancer Society, as many as 20% of people who die from lung cancer in the United States every year have never smoked or used any other form of tobacco. Leading researchers have started to classify lung cancer in never and non-smokers as having unique and distinct clinical, biological and pathological characteristics that have the potential to be impacted by new therapeutic options. According to market research and data analytics firm, GlobalData, approximately $10 billion was spent on NSCLC therapies in 2020, across the leading eight markets (by annual drug sales), with approximately $4 billion of this drug spend in the U.S. alone.

On September 28, 2021 Fortress Biotech, Inc. (NASDAQ: FBIO) ("Fortress"), an innovative biopharmaceutical company focused on acquiring, developing and commercializing or monetizing promising biopharmaceutical products and product candidates cost-effectively, reported that Lindsay A. Rosenwald, M.D., Chairman, President and Chief Executive Officer, will participate in the Benzinga Healthcare Small Cap Conference, scheduled to take place from September 29-30, 2021 (Press release, Fortress Biotech, SEP 28, 2021, View Source [SID1234590407]).

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Details of the events are as follows:

Presentation: The company will present a corporate update on Thursday, September 30, 2021, at 11:30 a.m. ET and will participate in one-on-one meetings during the conference.
Panel: Dr. Rosenwald will also participate in a panel discussion entitled, Immuno-Oncology: Harnessing the Human Body’s Power to Battle Cancer, on Thursday, September 30, 2021, at 12:35 p.m. ET.
The live events will stream from this link at the appropriate times. A replay of each event will be available on the Events page under the News & Media section of Fortress’ website: www.fortressbiotech.com shortly after the meeting for approximately 30 days.