On September 2, 2021 Scopus BioPharma Inc. (Nasdaq: "SCPS"), a clinical-stage biopharmaceutical company developing transformational therapeutics for serious diseases with significant unmet medical need, reported the launch of Duet Therapeutics (Press release, Scopus BioPharma, SEP 2, 2021, View Source [SID1234587254]).

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Duet Therapeutics integrates the management and clinical development of the immunotherapy assets of Scopus and Olimmune, acquired by Scopus in June 2021. Duet is a wholly-owned subsidiary of Scopus.

Joshua R. Lamstein, Chairman of Scopus, stated, "We are extremely excited to announce the launch of Duet Therapeutics. The integration of the immuno-oncology assets of Scopus and Olimmune creates a comprehensive, industry-leading portfolio of bi-functional cancer-targeting oligonucleotides. Our highly complementary IP-protected technologies all target STAT3 inhibition. We believe our oligonucleotide technologies are unique, highly differentiated and superior to other STAT3 inhibitors currently under development."

Alan Horsager, Ph.D., President and Chief Executive Officer of Duet and President — Immuno-Oncology for Scopus, stated, "Overseeing the integration and clinical development of Duet’s immuno-oncology platform is an extraordinary opportunity. It is a privilege to play a key role in integrating and developing Duet’s drug candidates. Based on the large body of scientific data, we firmly believe our oligonucleotide platform has enormous potential to address one of society’s most significant unmet medical needs — unprecedented treatments, and potentially cures, for many different types of cancer. I can think of no greater professional mission than creating new standards of care, improving patient outcomes and saving lives."

The Duet Platform is comprised of three complementary, underpinning technologies:

• RNA silencing CpG-STAT3siRNA ("DUET-01")
• Antisense CpG-STAT3ASO ("DUET-02")
• Protein degradation CpG-STAT3decoy ("DUET-03")
Dr. Horsager added, "The unique mechanism-of-action of these synthetic oligos comes from simultaneously targeting two intracellular immune pathways, STAT3 and TLR9. The targeted inhibition of STAT3, a master immune checkpoint inhibitor, reawakens immune cells and allows for the full potential of TLR9-driven immune responses."

DUET-01 is in a Phase 1 clinical trial, as a monotherapy, for B-cell non-Hodgkin lymphoma. In 2022, Duet is targeting to file two INDs for DUET-02 in two separate indications: genitourinary and head & neck cancers. Duet is also evaluating combination therapies with checkpoint inhibitors.

On September 2, 2021 The McQuade Center for Strategic Research and Development, LLC (MSRD), a member of the global Otsuka family of pharmaceutical companies, reported that it has entered an agreement with Sentinel Oncology (Sentinel), a drug discovery company (Press release, Sentinel Oncology, SEP 2, 2021, View Source [SID1234587242]).

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The McQuade Center for Strategic Research and Development at Otsuka in the U.S. will support the clinical development of a first-in-class therapeutic with the potential to treat Fragile X syndrome (FXS), a rare, genetic condition that causes intellectual disability, behavioral and learning challenges, and various physical characteristics1.

Under the terms of the agreement, MSRD and Sentinel will collaborate to support the Phase 1a and Phase 1b clinical trials for Sentinel’s investigational compound SOL784 with the opportunity to expand the collaboration after those studies.

"Although there are treatment options for the symptoms of Fragile X syndrome available today, none have been approved by regulatory authorities to address the underlying cause of this rare genetic disorder," said Robert McQuade, PhD, president, McQuade Center for Strategic Research and Development, LLC, and chief strategic officer, Otsuka Pharmaceutical Development & Commercialization, Inc. "Our two organizations share like-minded missions of delivering treatments to patients with unmet medical needs. We are hopeful that our collaboration can lead to the development of a potential therapeutic for people living with this condition."

"We are delighted to be collaborating with the MSRD team to advance SOL784 into clinical development" said Robert G Boyle, founder and CEO of Sentinel Oncology. "SOL784 targets the underlying disease biology of FXS and we are excited for the prospects of a drug which has the potential to provide real benefits to patients for whom there is an unmet medical need"

About Fragile X Syndrome

Fragile X syndrome (FXS) is a rare, genetic condition that causes intellectual disability, behavioral and learning challenges, and various physical characteristics. Though FXS occurs in both genders, males are more frequently affected than females, and generally with greater severity. FXS has been detected in all populations and ethnic groups. While researchers do not have an exact number for how many Americans (males and females) could have full-mutation Fragile X syndrome, estimates range between as few as 38,000 to as high as 87,000 people living with the condition.1

On September 2, 2021 MediciNova, Inc., a biopharmaceutical company traded on the NASDAQ Global Market (NASDAQ:MNOV) and the JASDAQ Market of the Tokyo Stock Exchange (Code Number: 4875), reported that MediciNova will participate in the virtual Morgan Stanley 19th Annual Global Healthcare Conference which will be held from September 9 – 15, 2021 (Press release, MediciNova, SEP 2, 2021, View Source [SID1234587240]). Yuichi Iwaki, MD, PhD, President and Chief Executive Officer, and Geoffrey O’Brien, JD/MBA, Vice President and Executive Officer, will be available for one-on-one meetings at this conference and investors may request a one-on-one meeting through Morgan Stanley.

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On September 2, 2021 Pulse Biosciences, Inc. (Nasdaq: PLSE), a novel bioelectric medicine company introducing the CellFX System powered by Nano-Pulse Stimulation (NPS) technology, reported plans to participate in the upcoming virtual H.C. Wainwright Global Investment Conference (Press release, Pulse Biosciences, SEP 2, 2021, View Source [SID1234587239]).

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Management is scheduled to participate and hold one-on-one meetings Tuesday, September 14, 2021. A presentation webcast will be available at the start of the conference on Monday, September 13, 2021, at 7:00 am ET. Interested parties may access the on-demand webcast at the same time on the "Investors" section of the Company’s website at www.pulsebiosciences.com.

On September 2, 2021 CohBar, Inc. (NASDAQ: CWBR), a clinical stage biotechnology company developing mitochondria based therapeutics to treat chronic diseases and extend healthy lifespan, reported that its Chief Executive Officer, Dr. Joseph Sarret, will present a company overview at the following investor conferences in September (Press release, CohBar, SEP 2, 2021, View Source [SID1234587237]).

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H.C. Wainwright Annual Global Investment Conference
September 13 – 15, 2021
Webcast: The presentation may be accessed via webcast on demand using the following link: View Source

Cantor Fitzgerald Virtual Global Healthcare Conference
Thursday, September 30, 2021 at 2:00pm ET
Webcast: The presentation may be accessed via webcast at the scheduled time, or following the presentation, using the following link: View Source

A replay of the webcasts will be available in the events section of the CohBar website for two weeks following the presentation.